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1.发明授权Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists 失效取代的苯稠合的杂环和碳环基作为nuerokinin拮抗剂
公开(公告)号：US5691362A
公开(公告)日：1997-11-25
申请号：US658790
申请日：1996-06-05
IPC分类号： C07D209/16 , C07D209/20 , C07D217/04 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/40 , C07D333/58
CPC分类号： C07D401/12 , C07D209/16 , C07D209/20 , C07D217/04 , C07D403/12 , C07D405/12
摘要： Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification; methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.
摘要翻译： 由结构式“IMAGE”表示的化合物或其药学上可接受的盐，其中变量如说明书中所定义; 公开了用所述化合物治疗哮喘，咳嗽，支气管痉挛，炎性疾病和胃肠道疾病的方法，以及包含所述化合物的药物组合物。
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2.发明授权Substituted butanol derivatives and their use as fragrance and flavor materials 有权取代的丁醇衍生物及其作为香料和香料的用途公开(公告)号：US09060535B2
公开(公告)日：2015-06-23
申请号：US12981758
申请日：2010-12-30
IPC分类号： A23L1/226 , A61K8/33 , A61K8/37 , A61K8/39 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q19/10 , A61K47/08 , A61K47/14 , C07C69/003 , C07C69/708 , C07C69/96 , C07C43/11 , C07C43/15 , C07C47/198 , C11D3/50
CPC分类号： A23L27/2028 , A23L2/56 , A23L27/20 , A23V2002/00 , A61K8/33 , A61K8/37 , A61K8/39 , A61K47/08 , A61K47/14 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q19/10 , C07C43/11 , C07C43/15 , C07C47/198 , C07C69/003 , C07C69/708 , C07C69/96 , C11B9/0015 , C11B9/0019 , C11D3/2068 , C11D3/2072 , C11D3/2093 , C11D3/50
摘要： The present invention is related to substituted butanol derivatives of the formula: wherein R is an unsubstituted or substituted C1-6 straight chain alkyl, an unsubstituted or substituted C3-6 branched chain alkyl, an unsubstituted or substituted C3-6 straight chain alkenyl, an unsubstituted or substituted C3-6 branched chain alkenyl, an unsubstituted or substituted C3-6 cycloalkyl, an unsubstituted or substituted C1-6 alkoxy, nitrile, halo, amino, an unsubstituted or substituted C1-6 alkylamino, an unsubstituted or substituted C1-6 dialkylamino, carboxy-C1-6 alkylamino, carboxy-C1-6 dialkylamino, an unsubstituted or substituted acetoxy, carboxy, an unsubstituted or substituted carboxyethyl, an unsubstituted or substituted C1-6 alkylcarbonyl, an unsubstituted or substituted C1-6 alkylcarboxy, an unsubstituted or substituted C1-6 alkylthio, an unsubstituted or substituted C1-6 alkyloxy, carboxamido, an unsubstituted or substituted C1-6 alkylcarboxamido or an unsubstituted or substituted C1-6 dialkylcarboxamido. Such compounds are useful in flavor or flavor compositions.
摘要翻译： 本发明涉及下式的取代丁醇衍生物：其中R是未取代或取代的C 1-6直链烷基，未取代或取代的C 3-6支链烷基，未取代或取代的C 3-6直链烯基， 未取代或取代的C 3-6支链烯基，未取代或取代的C 3-6环烷基，未取代或取代的C 1-6烷氧基，腈，卤素，氨基，未取代或取代的C 1-6烷基氨基，未取代或取代的C 1-6 二烷基氨基，羧基-C 1-6烷基氨基，羧基-C 1-6二烷基氨基，未取代或取代的乙酰氧基，羧基，未取代或取代的羧乙基，未取代或取代的C 1-6烷基羰基，未取代或取代的C 1-6烷基羧基， 或取代的C 1-6烷硫基，未取代或取代的C 1-6烷氧基，甲酰胺基，未取代或取代的C 1-6烷基羧酰胺基或未取代或取代的 C 1-6二烷基甲酰胺基。 这些化合物可用于风味或风味组合物。
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公开(公告)号：US06528522B2
公开(公告)日：2003-03-04
申请号：US09954863
申请日：2001-09-18
IPC分类号： A61K31435
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention discloses novel substituted imidazole compounds which have H3 receptor antagonist activity or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, congestion, inflammatory and CNS-related diseases and others.
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公开(公告)号：US06956139B2
公开(公告)日：2005-10-18
申请号：US10170123
申请日：2002-06-10
IPC分类号： A23G3/00 , A23G3/34 , A23G3/36 , A23G4/00 , A23G4/06 , A23G9/32 , A23G9/44 , A23G9/52 , A23L2/00 , A23L27/20 , A61K8/00 , A61K8/30 , A61K8/34 , A61K47/10 , A61P11/14 , A61Q1/00 , A61Q1/10 , A61Q5/00 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , C07C43/02 , C07C43/196 , C12G1/00 , C07C41/00 , A23L1/22 , A61K7/16 , C07C35/12
CPC分类号： A61Q13/00 , A23G3/36 , A23G4/06 , A23L27/204 , A61K8/34 , A61K2800/244 , A61Q11/00 , C07C43/196 , C07C2601/14
摘要： A cooling sensate compound having the general formula (I): where n is an integer from 2 to 6. The compound is effective in imparting a refreshing and cooling sensation of long duration. A cooling sensate composition having the general formula (I) is used in a variety of formulations to impart the refreshing and cooling sensation. These cooling sensates are useful in a variety of consumer products including mouth formulations, food products and toiletries.
摘要翻译： 具有通式（I）的冷却感觉化合物：其中n是2至6的整数。该化合物有效地赋予长时间的清爽和冷却感。 具有通式（I）的冷却感觉组合物用于各种制剂中以赋予清爽和冷却感。 这些冷却感觉可用于各种消费品，包括口服制剂，食品和洗浴用品。
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公开(公告)号：US06548474B1
公开(公告)日：2003-04-15
申请号：US09105165
申请日：1998-06-26
IPC分类号： A61K746
CPC分类号： C11D3/50 , C07C45/62 , C07C45/68 , C07C45/74 , C07C49/417 , C07C49/613 , C07C49/653 , C11B9/003 , C11B9/0034
摘要： Disubstituted cycloalkanones are prepared from one of 2-cyclopentylidenecyclopentan-1-one, 2-cyclohexylidenecyclohexan-1-one, 2-cyclopentylidenecyclohexan-1-one, or 2-cyclohexylidenecyclopentan-1-one. The resulting compounds were analyzed for their odor characteristics. The different compounds exhibited varied odor characteristics, which were not predictable from the structures of the compounds. The compounds are useful in the preparation of fragrance compositions and products formed from same.
摘要翻译： 2-取代的环烷酮由2-环戊烯基环戊烷-1-酮，2-亚环己烯环己烷-1-酮，2-环戊烯基环己烷-1-酮或2-亚环己烯环戊-1-酮中的一种制备。 分析所得化合物的气味特性。 不同的化合物表现出不同的气味特征，这些化合物的结构是不可预知的。 该化合物可用于制备香料组合物和由其形成的产品。
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公开(公告)号：US06899901B2
公开(公告)日：2005-05-31
申请号：US10464149
申请日：2003-06-17
申请人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo, Jr. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
发明人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo, Jr. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
IPC分类号： A23G3/34 , A23G3/00 , A23G3/36 , A23G4/00 , A23G4/06 , A23L2/00 , A23L27/00 , A23L27/20 , A61K8/00 , A61K8/31 , A61K8/34 , A61K8/35 , A61K8/42 , A61K8/49 , A61K8/92 , A61K8/96 , A61K8/97 , A61K31/075 , A61K31/11 , A61K31/335 , A61K36/00 , A61K36/534 , A61K36/61 , A61K36/67 , A61K36/81 , A61K47/00 , A61Q11/00 , A61Q13/00 , C07C43/196 , C09K3/00
CPC分类号： A61Q13/00 , A23G3/36 , A23G4/06 , A23L27/204 , A61K8/42 , A61K8/922 , A61K2800/244 , A61Q11/00 , C07C43/196 , C07C2601/14
摘要： The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.
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公开(公告)号：US6086644A
公开(公告)日：2000-07-11
申请号：US168415
申请日：1998-10-08
CPC分类号： C11C5/002
摘要： A scented candle includes a candle manufacturing material, a fragrance provider, and at least one of polypropylene glycol and polypropylene glycol monoalkyl ether with a general formula (I)H--(OC.sub.3 H.sub.6).sub.n --O--R (I)where n is an integer between 2 and 40 and R is H or an alkyl group with a carbon number between 1 and 10.
摘要翻译： 香味蜡烛包括蜡烛制造材料，香料供应商，以及通式（I）H-（OC 3 H 6）nOR（I）的聚丙二醇和聚丙二醇单烷基醚中的至少一种，其中n是2至40的整数 且R为H或碳数为1至10的烷基。
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公开(公告)号：US06890567B2
公开(公告)日：2005-05-10
申请号：US10625074
申请日：2003-07-22
申请人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo, Jr. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
发明人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo, Jr. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
IPC分类号： A23G3/34 , A23G3/00 , A23G3/36 , A23G4/00 , A23G4/06 , A23L2/00 , A23L27/00 , A23L27/20 , A61K8/00 , A61K8/31 , A61K8/34 , A61K8/35 , A61K8/42 , A61K8/49 , A61K8/92 , A61K8/96 , A61K8/97 , A61K31/075 , A61K31/11 , A61K31/335 , A61K36/00 , A61K36/534 , A61K36/61 , A61K36/67 , A61K36/81 , A61K47/00 , A61Q11/00 , A61Q13/00 , C07C43/196 , C09K3/00
CPC分类号： A61Q13/00 , A23G3/36 , A23G4/06 , A23L27/204 , A61K8/42 , A61K8/922 , A61K2800/244 , A61Q11/00 , C07C43/196 , C07C2601/14
摘要： The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.
摘要翻译： 本发明涉及包含至少一种冷却感，加温感和刺痛感的敏感组合物。 刺痛的感觉是至少一种Jambu Oleoresin和Spilanthol。 本发明还涉及在食品，药物或个人护理产品中使用感觉组合物的方法。
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公开(公告)号：US06780443B1
公开(公告)日：2004-08-24
申请号：US09498592
申请日：2000-02-04
申请人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo, Jr. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
发明人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo, Jr. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
IPC分类号： A61K716
CPC分类号： A61Q13/00 , A23G3/36 , A23G4/06 , A23L27/204 , A61K8/42 , A61K8/922 , A61K2800/244 , A61Q11/00 , C07C43/196 , C07C2601/14
摘要： The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.
摘要翻译： 本发明涉及包含至少一种冷却感，加温感和刺痛感的敏感组合物。 刺痛的感觉是至少一种Jambu Oleoresin和Spilanthol。 本发明还涉及在食品，药物或个人护理产品中使用感觉组合物的方法。
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公开(公告)号：US06506756B2
公开(公告)日：2003-01-14
申请号：US09954867
申请日：2001-09-18
IPC分类号： C07D40112
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention discloses novel substituted imidazole compounds which have dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.
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