公开(公告)号：US06087144A

公开(公告)日：2000-07-11

申请号：US447314

申请日：1995-05-22

申请人： David T. Scadden ,  Kevin P. Baker ,  Will F. Baron

发明人： David T. Scadden ,  Kevin P. Baker ,  Will F. Baron

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P43/00 ,  C07H21/04 ,  C07K14/435 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C07K16/28 ,  C12N1/21 ,  C12N5/02 ,  C12N9/12 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12N15/54 ,  C12P21/08 ,  C12Q1/48 ,  C12R1/19 ,  C12R1/91 ,  G01N33/543 ,  G01N33/566 ,  G01N33/573

CPC分类号： C07K16/28 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C12N9/12 ,  C12Q1/485 ,  G01N33/54306 ,  G01N33/566 ,  G01N33/573 ,  A61K38/00 ,  G01N2333/705 ,  G01N2333/912 ,  G01N2333/9121 ,  G01N2500/00 ,  Y10S435/975

摘要： The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.

摘要翻译： 已经从人和/或鼠细胞组织中纯化称为Rse和HPTK6的蛋白酪氨酸激酶受体。 已经使用PCR扩增从人肝癌细胞系（即Hep 3B）的cDNA文库克隆了Rse和HPTK6。 本文提供了编码Rse和HPTK6的核酸序列，其可用作诊断和Rse和HPTK6的重组制备。 Rse和HPTK6用于制备和纯化其抗体和诊断测定。

公开(公告)号：US06825324B2

公开(公告)日：2004-11-30

申请号：US09223490

申请日：1998-12-30

申请人： Kevin P. Baker ,  Will F. Baron

发明人： Kevin P. Baker ,  Will F. Baron

IPC分类号： C07K1600

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C12N9/12 ,  C12Q1/485 ,  G01N33/54306 ,  G01N33/566 ,  G01N33/573 ,  G01N2333/705 ,  G01N2333/912 ,  G01N2333/9121 ,  G01N2500/00 ,  Y10S435/975

摘要： The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.

摘要翻译： 已经从人和/或鼠细胞组织中纯化称为Rse和HPTK6的蛋白酪氨酸激酶受体。 已经使用PCR扩增从人肝癌细胞系（即Hep 3B）的cDNA文库克隆了Rse和HPTK6。 本文提供了编码Rse和HPTK6的核酸序列，其可用作诊断和Rse和HPTK6的重组制备。 Rse和HPTK6用于制备和纯化其抗体和诊断测定。

公开(公告)号：US06482626B2

公开(公告)日：2002-11-19

申请号：US10074509

申请日：2002-02-11

申请人： Kevin P. Baker ,  Will F. Baron

发明人： Kevin P. Baker ,  Will F. Baron

IPC分类号： C12N1555

CPC分类号： C12N9/22 ,  A61K38/00

摘要： This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic acid sequences encoding LS-DNase, thereby enabling the production of LS-DNase by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of LS-DNase.

公开(公告)号：US06569429B1

公开(公告)日：2003-05-27

申请号：US09861034

申请日：2001-05-18

申请人： Kevin P. Baker ,  Will F. Baron

发明人： Kevin P. Baker ,  Will F. Baron

IPC分类号： A61K3846

CPC分类号： C12N9/22 ,  A61K38/00

摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.

公开(公告)号：US06265195B1

公开(公告)日：2001-07-24

申请号：US08639294

申请日：1996-04-25

申请人： Kevin P. Baker ,  Will F. Baron

发明人： Kevin P. Baker ,  Will F. Baron

IPC分类号： C12N916

CPC分类号： C12N9/22 ,  A61K38/00

摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.

摘要翻译： 本发明涉及一种新的人脱氧核糖核酸酶，称为人类DNA酶II。 本发明提供了编码人DNase II的核酸序列，从而使得能够以足以临床使用的量的重组DNA方法生产人类DNA酶II。 本发明还涉及人类DNA酶II的药物组合物和诊断和治疗用途。

公开(公告)号：US20090041742A1

公开(公告)日：2009-02-12

申请号：US11740860

申请日：2007-04-26

申请人： Kevin P. Baker ,  Will F. Baron

发明人： Kevin P. Baker ,  Will F. Baron

IPC分类号： A61K38/46 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  C12P21/06 ,  C12N9/14 ,  C07K16/00

CPC分类号： C12N9/22 ,  A61K38/00

摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.

摘要翻译： 本发明涉及一种新的人脱氧核糖核酸酶，称为人类DNA酶II。 本发明提供了编码人DNase II的核酸序列，从而使得能够以足以临床使用的量的重组DNA方法生产人类DNA酶II。 本发明还涉及人类DNA酶II的药物组合物和诊断和治疗用途。

公开(公告)号：US07033796B2

公开(公告)日：2006-04-25

申请号：US10646760

申请日：2003-08-25

申请人： Kevin P. Baker ,  Will F. Baron

发明人： Kevin P. Baker ,  Will F. Baron

IPC分类号： C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/00 ,  C07H21/04

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C12N9/12 ,  C12Q1/485 ,  G01N33/54306 ,  G01N33/566 ,  G01N33/573 ,  G01N2333/705 ,  G01N2333/912 ,  G01N2333/9121 ,  G01N2500/00 ,  Y10S435/975

摘要： The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.

摘要翻译： 已经从人和/或鼠细胞组织中纯化称为Rse和HPTK6的蛋白酪氨酸激酶受体。 已经使用PCR扩增从人肝癌细胞系（即Hep 3B）的cDNA文库克隆了Rse和HPTK6。 本文提供了编码Rse和HPTK6的核酸序列，其可用作诊断和Rse和HPTK6的重组制备。 Rse和HPTK6用于制备和纯化其抗体和诊断测定。

公开(公告)号：US07777007B2

公开(公告)日：2010-08-17

申请号：US10219533

申请日：2002-08-14

申请人： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

发明人： Kevin P. Baker ,  Luc Desnoyers ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Victoria Smith ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C07K16/00

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07718770B2

公开(公告)日：2010-05-18

申请号：US10183012

申请日：2002-06-26

申请人： Kevin P. Baker ,  Jian Chen ,  Luc Desnoyers ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  James Pan ,  Victoria Smith ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Jian Chen ,  Luc Desnoyers ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  James Pan ,  Victoria Smith ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K14/435 ,  C07H21/00

CPC分类号： C07K14/47 ,  A01K2217/075 ,  A01K2227/105 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/82 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2319/30 ,  C12N9/90 ,  C12N2799/026 ,  C12Q1/6816 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5082 ,  G01N33/5308 ,  G01N33/574 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57484 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2500/10 ,  C12Q2563/131 ,  C12Q2527/137

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07700736B2

公开(公告)日：2010-04-20

申请号：US10123322

申请日：2002-04-15

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K16/18 ,  C12P21/08

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。