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公开(公告)号：US07699990B2
公开(公告)日：2010-04-20
申请号：US11581147
申请日：2006-10-16
申请人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
发明人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
IPC分类号： B01D15/08
CPC分类号： G01N35/1097 , G01N1/38 , G01N30/20 , G01N30/34 , G01N2030/027 , Y10T436/2575
摘要： A separation analyzer for transferring solutions, while changing mixing ratios of the solutions, wherein a flow passage from a first pump, a flow passage from a second pump, and a passage for sample introduction section, the flow passages being connected, which further comprises a flow switching means for temporarily storing the solutions, whereby the flow switching means alternatively makes a first state for pushing out the solutions in a second sampling loop to the sample introduction section by the second pump, while transferring the solutions to the first sampling loop; and a second state for pushing out the solutions in the first sampling loop by the second pump, while transferring the solutions from the first pump to the second sampling loop.
摘要翻译： 一种用于输送溶液的分离器，同时改变溶液的混合比，其中来自第一泵的流动通道，来自第二泵的流动通道和用于样品引入部分的通道，流动通道连接，还包括 流动切换装置，用于临时存储溶液，由此流动切换装置交替地将第二状态用于将第二取样回路中的溶液推出到第二泵的样品引入部分，同时将溶液转移到第一取样回路; 以及第二状态，用于在将所述解决方案从所述第一泵传送到所述第二采样回路的同时，通过所述第二泵推出所述第一采样回路中的所述解。
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公开(公告)号：US08048312B2
公开(公告)日：2011-11-01
申请号：US12685724
申请日：2010-01-12
申请人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
发明人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
IPC分类号： B01D15/08
CPC分类号： G01N35/1097 , G01N1/38 , G01N30/20 , G01N30/34 , G01N2030/027 , Y10T436/2575
摘要： A separation analyzer for transferring solutions, while changing mixing ratios of the solutions, wherein a flow passage from a first pump, a flow passage from a second pump, and a passage for sample introduction section, the flow passages being connected, which further comprises a flow switching means for temporarily storing the solutions, whereby the flow switching means alternatively makes a first state for pushing out the solutions in a second sampling loop to the sample introduction section by the second pump, while transferring the solutions to the first sampling loop; and a second state for pushing out the solutions in the first sampling loop by the second pump, while transferring the solutions from the first pump to the second sampling loop.
摘要翻译： 一种用于输送溶液的分离器，同时改变溶液的混合比，其中来自第一泵的流动通道，来自第二泵的流动通道和用于样品引入部分的通道，流动通道连接，还包括 流动切换装置，用于临时存储溶液，由此流动切换装置交替地将第二状态用于将第二取样回路中的溶液推出到第二泵的样品引入部分，同时将溶液转移到第一取样回路; 以及第二状态，用于在将所述解决方案从所述第一泵传送到所述第二采样回路的同时，通过所述第二泵推出所述第一采样回路中的所述解。
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公开(公告)号：US20100107782A1
公开(公告)日：2010-05-06
申请号：US12685724
申请日：2010-01-12
申请人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
发明人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
CPC分类号： G01N35/1097 , G01N1/38 , G01N30/20 , G01N30/34 , G01N2030/027 , Y10T436/2575
摘要： A separation analyzer for transferring solutions, while changing mixing ratios of the solutions, wherein a flow passage from a first pump, a flow passage from a second pump, and a passage for sample introduction section, the flow passages being connected, which further comprises a flow switching means for temporarily storing the solutions, whereby the flow switching means alternatively makes a first state for pushing out the solutions in a second sampling loop to the sample introduction section by the second pump, while transferring the solutions to the first sampling loop; and a second state for pushing out the solutions in the first sampling loop by the second pump, while transferring the solutions from the first pump to the second sampling loop.
摘要翻译： 一种用于输送溶液的分离器，同时改变溶液的混合比，其中来自第一泵的流动通道，来自第二泵的流动通道和用于样品引入部分的通道，流动通道连接，还包括 流动切换装置，用于临时存储溶液，由此流动切换装置交替地将第二状态用于将第二取样回路中的溶液推出到第二泵的样品引入部分，同时将溶液转移到第一取样回路; 以及第二状态，用于在将所述解决方案从所述第一泵传送到所述第二采样回路的同时，通过所述第二泵推出所述第一采样回路中的所述解。
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公开(公告)号：US20070031285A1
公开(公告)日：2007-02-08
申请号：US11581147
申请日：2006-10-16
申请人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
发明人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
IPC分类号： G01N33/00
CPC分类号： G01N35/1097 , G01N1/38 , G01N30/20 , G01N30/34 , G01N2030/027 , Y10T436/2575
摘要： A separation analyzer for transferring solutions, while changing mixing ratios of the solutions, wherein a flow passage from a first pump, a flow passage from a second pump, and a passage for sample introduction section, the flow passages being connected, which further comprises a flow switching means for temporarily storing the solutions, whereby the flow switching means alternatively makes a first state for pushing out the solutions in a second sampling loop to the sample introduction section by the second pump, while transferring the solutions to the first sampling loop; and a second state for pushing out the solutions in the first sampling loop by the second pump, while transferring the solutions from the first pump to the second sampling loop.
摘要翻译： 一种用于输送溶液的分离器，同时改变溶液的混合比，其中来自第一泵的流动通道，来自第二泵的流动通道和用于样品引入部分的通道，流动通道连接，还包括 流动切换装置，用于临时存储溶液，由此流动切换装置交替地将第二状态用于将第二取样回路中的溶液推出到第二泵的样品引入部分，同时将溶液转移到第一取样回路; 以及第二状态，用于在将所述解决方案从所述第一泵传送到所述第二采样回路的同时，通过所述第二泵推出所述第一采样回路中的所述解。
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公开(公告)号：US07135111B2
公开(公告)日：2006-11-14
申请号：US10776263
申请日：2004-02-12
申请人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
发明人： Kisaburo Deguchi , Shinya Ito , Masahito Ito
IPC分类号： B01D15/08
CPC分类号： G01N35/1097 , G01N1/38 , G01N30/20 , G01N30/34 , G01N2030/027 , Y10T436/2575
摘要： A separation analyzer for transferring solutions, while changing mixing ratios of the solutions, wherein a flow passage from a first pump, a flow passage from a second pump, and a passage for sample introduction section, the flow passages being connected, which further comprises a flow switching means for temporarily storing the solutions, whereby the flow switching means alternatively makes a first state for pushing out the solutions in a second sampling loop to the sample introduction section by the second pump, while transferring the solutions to the first sampling loop; and a second state for pushing out the solutions in the first sampling loop by the second pump, while transferring the solutions from the first pump to the second sampling loop.
摘要翻译： 一种用于输送溶液的分离器，同时改变溶液的混合比，其中来自第一泵的流动通道，来自第二泵的流动通道和用于样品引入部分的通道，流动通道连接，还包括 流动切换装置，用于临时存储溶液，由此流动切换装置交替地将第二状态用于将第二取样回路中的溶液推出到第二泵的样品引入部分，同时将溶液转移到第一取样回路; 以及第二状态，用于在将所述解决方案从所述第一泵传送到所述第二采样回路的同时，通过所述第二泵推出所述第一采样回路中的所述解。
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公开(公告)号：US07211790B2
公开(公告)日：2007-05-01
申请号：US11132174
申请日：2005-05-19
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
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公开(公告)号：US20050159902A1
公开(公告)日：2005-07-21
申请号：US11037043
申请日：2005-01-19
申请人： Izumi Ogata , Shinya Ito , Yasuhiro Takegawa , Kisaburo Deguchi , Hiroaki Nakagawa , Shin-Ichiro Nishimura
发明人： Izumi Ogata , Shinya Ito , Yasuhiro Takegawa , Kisaburo Deguchi , Hiroaki Nakagawa , Shin-Ichiro Nishimura
CPC分类号： H01J49/0036 , G16C20/20
摘要： In a database MSn spectrum search, search of a known compound whose principal chain is identical to that of an unknown compound is enabled, thereby allowing analysis of an entire structure even if the entire structures of the known compound in database and that of the measured unknown compound are not identical. The MSn spectrum obtained in the MSn measurement of the unknown compound is compared with all the MSm spectra (m≧1) in the database regardless of MSn generation. In the MSn measurement of a series of related compounds including various types of different side chains of the same principal chain, such as in the case of biopolymers, it becomes possible to determine the structure of the principal chain using a database search even if the entire structure is not clear. And the estimation of the entire structure is made possible on the basis of the principal chain structure.
摘要翻译： 在数据库MS搜索中，搜索其主链与未知化合物的主链相同的已知化合物，从而允许分析整个结构，即使已知化合物的整个结构 在数据库中和测量的未知化合物的数据不相同。 将未知化合物的MS 测量中获得的MS 光谱与所有MS谱（m> = 1）进行比较 数据库，无论MS n 生成。 在一系列相关化合物（包括同一主链的各种不同侧链的相关化合物）的测定中，例如在生物聚合物的情况下，可以确定主链的结构 使用数据库搜索即使整个结构不清楚。 而整个结构的估计是可以在主链结构的基础上进行的。
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公开(公告)号：US20050258355A1
公开(公告)日：2005-11-24
申请号：US11132174
申请日：2005-05-19
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
摘要翻译： 本发明意在确定难以通过分离单元彼此分离并且不能被MS鉴别的混合化合物之间的存在比例。 在具有MS分析功能的质谱仪中，用于将从分离单元洗脱的样品离子化以将样品分离成单个组分，使所需质量数的离子分段，并进行片段的质量分析 离子，质谱仪包括存储每个异构体的质谱中异构体存在比和特定离子强度比之间相关信息的数据库。 甚至对于异构体的混合样品（如对映异构体）也可以澄清异构体比例，这些异构体难以通过分离单元彼此分离并且不能被MS鉴别。
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公开(公告)号：US06942793B2
公开(公告)日：2005-09-13
申请号：US10778047
申请日：2004-02-17
申请人： Shinya Ito , Kisaburo Deguchi
发明人： Shinya Ito , Kisaburo Deguchi
CPC分类号： G01N30/463 , G01N30/468 , G01N30/7233 , G01N2030/027 , G01N2030/121 , G01N2030/8411 , G01N30/466
摘要： A liquid chromatograph mass spectrometer comprises: a pump; a sample injector; a plurality of separation columns, including a first separation column and a second separation column; and mass spectrometer. The liquid chromatograph mass spectrometer further comprises: a plurality of trap columns for retaining a sample component separated by the first separation column; a first switching valve for switching between one of the plurality of trap columns and another one of the plurality of trap columns at regular time intervals in such a way that when the one of the plurality of trap columns is connected to the first separation column, the another one of the plurality of trap columns is connected to the pump, and vice versa; and a second switching valve for, when a trap column is connected to the pump, further connecting the trap column to the second separation column after connecting the trap column to solution discharging means during a predetermined initial time period, the second separation column being connected to the mass spectrometer and capable of separating the sample component in a shorter time than the first separation column.
摘要翻译： 液相色谱质谱仪包括：泵; 样品注射器 多个分离塔，包括第一分离塔和第二分离塔; 和质谱仪。 液相色谱质谱仪还包括：多个捕集塔，用于保持由第一分离塔分离的样品组分; 第一切换阀，用于以规定的时间间隔切换多个捕集塔中的一个与另一个捕集塔之间，以便当多个捕集塔中的一个与第一分离塔连接时， 多个捕集塔中的另一个连接到泵，反之亦然; 以及第二切换阀，当在预定的初始时间段内将捕集塔连接到所述泵时，在将所述捕集塔连接到溶液排出装置之后，还将所述捕集塔连接到所述第二分离塔，所述第二分离柱连接到 该质谱仪能够在比第一分离塔更短的时间内分离样品组分。
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公开(公告)号：US07462817B2
公开(公告)日：2008-12-09
申请号：US11723995
申请日：2007-03-23
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
摘要翻译： 本发明意在确定难以通过分离单元彼此分离并且不能被MS鉴别的混合化合物之间的存在比例。 在具有MSn分析功能的质谱仪中，用于将从分离单元洗脱的样品离子化，用于将样品分离成单独的组分，将所需质量数的离子分段，并进行碎片离子的质量分析，质谱仪包括数据库 在每个异构体的质谱中存储异构体存在比和特定离子强度比之间的相关信息。 甚至对于异构体的混合样品（如对映异构体）也可以澄清异构体比例，这些异构体难以通过分离单元彼此分离并且不能被MS鉴别。
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