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29 条记录 (耗时 0.028 秒)

    Heterocyclic ligands for integrin imaging and therapy
    4.
    发明授权
    Heterocyclic ligands for integrin imaging and therapy 有权
    用于整合素成像和治疗的杂环配体

    公开(公告)号：US08486370B2

    公开(公告)日：2013-07-16

    申请号：US12440219

    申请日：2007-09-07

    申请人： Richard D. Carpenter ,  Mirela Andrei ,  Ruiwu Liu ,  Kit S. Lam ,  Mark J. Kurth

    发明人： Richard D. Carpenter ,  Mirela Andrei ,  Ruiwu Liu ,  Kit S. Lam ,  Mark J. Kurth

    IPC分类号： A61K51/00

    CPC分类号： A61K51/0459 ,  A61K9/0014 ,  A61K9/0019 ,  A61K51/0453 ,  A61K51/0455 ,  Y02A50/401 ,  Y02A50/475

    摘要： The present invention provides α4β1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural amino acid or a D-amino acid, and wherein n is an integer of from 3 to 20. Methods are provided for administering the ligands for treating cancer, inflammatory diseases, and autoimmune diseases. Also provided are methods for administering the ligands for imaging a tumor, organ, or tissue in a subject.

    摘要翻译： 本发明提供显示高结合亲和力，特异性和稳定性的α4β1整联蛋白配体。 配体包含具有n个独立选择的氨基酸的肽，其中至少一个氨基酸是非天然氨基酸或D-氨基酸，并且其中n是3-20的整数。提供了用于给予 治疗癌症，炎性疾病和自身免疫性疾病。 还提供了施用用于成像受试者的肿瘤，器官或组织的配体的方法。

    Chemical Antibodies for Immunotherapy and Imaging
    5.
    发明申请
    Chemical Antibodies for Immunotherapy and Imaging 审中-公开
    化学抗体免疫治疗和成像

    公开(公告)号：US20100021379A1

    公开(公告)日：2010-01-28

    申请号：US12306244

    申请日：2007-06-28

    申请人： Kit S. Lam ,  Pappanaicken R. Kumaresan ,  Amanda Enstrom ,  Ruiwu Liu

    发明人： Kit S. Lam ,  Pappanaicken R. Kumaresan ,  Amanda Enstrom ,  Ruiwu Liu

    IPC分类号： A61K51/00 ,  A61K49/00 ,  A61K39/395 ,  C12Q1/02 ,  C12N9/96 ,  C07K16/00

    CPC分类号： A61K47/6835 ,  A61K47/62 ,  A61K47/646

    摘要： The present invention provides antibody conjugates comprising a targeting agent covalently attached to an antibody or fragment thereof. The antibody conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, infectious diseases, and neurological disorders. Kits containing the antibody conjugates described herein find utility in a wide range of applications including, for example, in vivo imaging and immunotherapy.

    摘要翻译： 本发明提供了包含与抗体或其片段共价连接的靶向试剂的抗体缀合物。 本发明的抗体缀合物特别可用于成像肿瘤，器官或组织并用于治疗诸如癌症，炎性疾病，自身免疫疾病，感染性疾病和神经障碍的疾病和病症。 含有本文所述的抗体缀合物的试剂盒可用于广泛的应用，包括例如体内成像和免疫治疗。

    Aβ-binding small molecules
    8.
    发明授权
    Aβ-binding small molecules 有权
    A＆bgr; - 结合的小分子

    公开(公告)号：US08168800B2

    公开(公告)日：2012-05-01

    申请号：US12740329

    申请日：2008-10-31

    申请人： Lee-Way Jin ,  Kit S. Lam ,  Ruiwu Liu ,  Hyun-Seok Hong ,  Izumi Maezawa

    发明人： Lee-Way Jin ,  Kit S. Lam ,  Ruiwu Liu ,  Hyun-Seok Hong ,  Izumi Maezawa

    IPC分类号： C07D491/052

    CPC分类号： C07D491/052 ,  A61K51/041 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0463 ,  C07B2200/05

    摘要： In one aspect, the present invention provides for compounds and labeled compounds of Formula I, and pharmaceutical compositions thereof. In another aspect, the present invention provides for methods of using compounds or labeled compounds of Formula I for various therapeutic and imaging purposes, including, but not limited to, treating Alzheimer's disease in patient and imaging Aβ peptide aggregates in a patient.

    摘要翻译： 一方面，本发明提供式I化合物和标记的化合物及其药物组合物。 另一方面，本发明提供了使用式I化合物或标记化合物用于各种治疗和成像目的的方法，包括但不限于在患者和成像中治疗阿尔茨海默氏病A＆bgr; 肽聚集体在患者体内。

    Method for determining differences in molecular interactions and for screening a combinatorial library
    10.
    发明授权
    Method for determining differences in molecular interactions and for screening a combinatorial library 失效
    确定分子相互作用差异和筛选组合文库的方法

    公开(公告)号：US07291456B2

    公开(公告)日：2007-11-06

    申请号：US10057178

    申请日：2002-01-24

    申请人： Kit S. Lam ,  Alan L. Lehman

    发明人： Kit S. Lam ,  Alan L. Lehman

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/543

    摘要： The invention includes a method for determining the differences between the molecular interactions of two different mixtures of molecules and identifying ligands specific for molecules in one mixture. The method utilizes a combinatorial library to compare the molecular interactions of the two mixtures and eliminates those interactions that are common to both mixtures and those that are unique to the first mixture, such that interactions essentially unique to the target mixture are identified. Ligands specific for molecules in the target mixture can then be identified. The invention also includes a method of screening a combinatorial library to distinguish between true positive beads and false positive beads and to provide for the identification of ligands specific for target molecules.

    摘要翻译： 本发明包括用于确定两种不同分子混合物的分子相互作用之间的差异并鉴定在一种混合物中分子特异性的配体的方法。 该方法利用组合文库来比较两种混合物的分子相互作用，并消除了混合物和第一种混合物独有的那些相互作用，从而确定了目标混合物基本上独特的相互作用。 然后可以鉴定目标混合物中分子特异性的配体。 本发明还包括筛选组合文库以区分真阳性珠和假阳性珠并提供对靶分子特异性的配体的鉴定的方法。