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1.发明授权
公开(公告)号：US4804662A
公开(公告)日：1989-02-14
申请号：US46222
申请日：1987-05-05
申请人： Klaus Nickisch , Randall E. Lis , William C. Lumma, Jr. , Thomas K. Morgan, Jr. , Ronald A. Wohl
发明人： Klaus Nickisch , Randall E. Lis , William C. Lumma, Jr. , Thomas K. Morgan, Jr. , Ronald A. Wohl
IPC分类号： C07D521/00 , A61K31/495 , A61K31/415 , C07D403/10
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Novel substituted 4-[1H-imidazol-1-yl]benzamides and their use in the treatment of cardiac arrthythmias especially as Class III or combination Class I/III antiarrhythmic agents is described. Pharmaceutical formulations containing such compounds are also disclosed.
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公开(公告)号：US5051423A
公开(公告)日：1991-09-24
申请号：US218195
申请日：1988-07-13
申请人： Randall E. Lis , William C. Lumma, Jr. , Thomas K. Morgan, Jr. , Klaus Nickisch , Ronald A. Wohl
发明人： Randall E. Lis , William C. Lumma, Jr. , Thomas K. Morgan, Jr. , Klaus Nickisch , Ronald A. Wohl
IPC分类号： A61K31/18 , A61K31/415 , A61P9/00 , A61P9/06 , C07C311/08 , C07D233/58 , C07D233/60 , C07D233/61 , C07D295/08 , C07D295/088 , C07D295/135 , C07D295/18 , C07D295/192 , C07D521/00
CPC分类号： C07D295/192 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/135
摘要： Novel derivatized alkanolamines of the following structural formula ##STR1## are described as useful cardiovascular agents. Most especially described is their usefulness as cardiovascular agents exhibiting an antiarrhythmic effect. Said antiarrhythmic effect is of a combination Class II/Class III variety. Pharmaceutical formulations containing such compounds are also described.
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公开(公告)号：US4851526A
公开(公告)日：1989-07-25
申请号：US93425
申请日：1987-09-04
申请人： Stanley S. Greenberg , Randall E. Lis , William C. Lumma, Jr. , Klaus Nickisch , Ronald A. Wohl
发明人： Stanley S. Greenberg , Randall E. Lis , William C. Lumma, Jr. , Klaus Nickisch , Ronald A. Wohl
IPC分类号： C07D233/60 , C07D233/90 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Novel 1-(4-substituted phenyl)-1H-imidazoles and their use as antiarrhythmic, anti-hypertensive and anti-ischemic agents is described. Pharmaceutical formulations containing such compounds are also discussed.
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公开(公告)号：US4581370A
公开(公告)日：1986-04-08
申请号：US513143
申请日：1983-07-12
IPC分类号： C07D233/34 , A61K31/415 , A61K31/4166 , A61K31/435 , A61P9/06 , C07C17/00 , C07C17/26 , C07C17/263 , C07C33/48 , C07C33/50 , C07C45/65 , C07D233/56 , C07D233/58 , C07D233/60 , C07D233/61 , C07D521/00
CPC分类号： C07C17/00 , C07C17/263 , C07C17/2632 , C07C17/2635 , C07C309/30 , C07C33/483 , C07C33/50 , C07C45/65 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.The compounds are described by the following formula: ##STR1##
摘要翻译： 所述的咪唑鎓盐可用作抗心律失常药。 提供了通过增加心脏组织的耐火性来治疗心律失常的方法以及含有这种咪唑鎓盐的药物制剂。 化合物由下式描述：
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公开(公告)号：US4689341A
公开(公告)日：1987-08-25
申请号：US881760
申请日：1986-07-03
IPC分类号： C07D233/34 , A61K31/415 , A61K31/4166 , A61K31/435 , A61P9/06 , C07C17/00 , C07C17/26 , C07C17/263 , C07C33/48 , C07C33/50 , C07C45/65 , C07D233/56 , C07D233/58 , C07D233/60 , C07D233/61 , C07D521/00
CPC分类号： C07C17/00 , C07C17/263 , C07C17/2632 , C07C17/2635 , C07C309/30 , C07C33/483 , C07C33/50 , C07C45/65 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.
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公开(公告)号：US4613609A
公开(公告)日：1986-09-23
申请号：US675172
申请日：1984-11-27
IPC分类号： C07C17/00 , C07C17/26 , C07C17/263 , C07C33/48 , C07C33/50 , C07C45/65 , C07D233/58 , C07D521/00 , A61K31/415
CPC分类号： C07C205/17 , C07C17/00 , C07C17/263 , C07C17/2632 , C07C17/2635 , C07C205/11 , C07C309/04 , C07C309/30 , C07C33/483 , C07C33/50 , C07C45/65 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.
摘要翻译： 所述的咪唑鎓盐可用作抗心律失常药。 提供了通过增加心脏组织的耐火性来治疗心律失常的方法以及含有这种咪唑鎓盐的药物制剂。
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7.发明授权Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents 失效新型N- [4-（氨基取代）苯基]甲磺酰胺及其作为心血管药物的用途
公开(公告)号：US4906634A
公开(公告)日：1990-03-06
申请号：US165315
申请日：1988-03-08
IPC分类号： C07C311/08 , C07C317/34 , C07C323/37 , C07D207/06 , C07D211/14 , C07D211/46 , C07D243/08 , C07D295/135
CPC分类号： C07D295/135 , C07C311/08 , C07C317/34 , C07C323/37 , C07D207/06 , C07D211/14 , C07D211/46 , C07D243/08 , C07C2101/02 , C07C2101/14
摘要： Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.
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8.发明授权
公开(公告)号：US5051422A
公开(公告)日：1991-09-24
申请号：US408020
申请日：1989-09-15
IPC分类号： A61K31/495 , A61P9/06 , C07D241/04 , C07D403/12
CPC分类号： C07D403/12 , C07D241/04
摘要： This invention relates to novel 2-substituted-1(4)-aryl piperazines and to a process for their preparation. The compounds of this invention have been found to have cardiovascular, primarily antiarrhythmic effects and are of the following general formula I ##STR1## wherein R is hydrogen, lower alkyl or benzyl; and R.sub.1 and R.sub.2 are the same or independently hydrogen, lower alkyl, lower alkoxy or halogen;Z is ##STR2## --NR.sub.3 --CH.sub.2 --, --OCH.sub.2 --, --NR.sub.3 --, --O-- or --NR.sub.3 SO.sub.2 -- andQ is (C.sub.1 -C.sub.4) alkyl--SO.sub.2 --NR.sub.4 -- or ##STR3## R.sub.3 is hydrogen, lower alkyl, allyl or loweralkoxyloweralkyl; and included in the descriptors of the compounds of Formula I is the proviso that when R.sub.4 is methyl then ##STR4## must be in the 2 position of Formula I.
摘要翻译： 本发明涉及新的2-取代-1（4） - 芳基哌嗪及其制备方法。 已经发现本发明的化合物具有心血管，主要是抗心律失常作用，并且具有以下通式I其中R是氢，低级烷基或苄基; 且R 1和R 2相同或独立地为氢，低级烷基，低级烷氧基或卤素; Z是-NR 3 -CH 2 - ， - OCH 2 - ， - NR 3 - ， - O-或-NR 3 SO 2 - ，Q是（C 1 -C 4）烷基-SO 2 -NR 4 - 或R 3是氢， ，烯丙基或低级烷氧基低级烷基; 并且包括在式I化合物的描述中的条件是当R 4为甲基时，则必须在式I的2位。
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公开(公告)号：US4545995A
公开(公告)日：1985-10-08
申请号：US513144
申请日：1983-07-12
IPC分类号： A61K31/275 , A61K31/14 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/235 , A61P9/06 , B01J23/00 , B01J23/40 , C07B61/00 , C07C17/26 , C07C17/263 , C07C33/30 , C07C67/00 , C07C209/00 , C07C209/12 , C07C211/28 , C07C211/63 , C07C213/00 , C07C215/66 , C07C217/62 , C07C217/74 , C07C227/00 , C07C229/38 , C07C231/00 , C07C233/43 , C07C237/30 , C07C253/00 , C07C255/58 , C07C275/40 , C07C301/00 , C07C311/00 , C07C311/08 , C07C311/37 , C07C311/39 , C07C313/00 , C07C317/32 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/48 , C07C91/00 , C07C121/50
CPC分类号： C07C211/63 , C07C17/263 , C07C17/2632 , C07C205/11 , C07C211/29 , C07C211/49 , C07C229/38 , C07C255/58 , C07C275/40 , C07C309/30 , C07C309/73 , C07C311/08 , C07C311/16 , C07C311/21 , C07C317/32 , C07C33/30 , Y10S514/821
摘要： The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such ammonium salts.
摘要翻译： 本文所述的新型不饱和芳基烷基铵盐可用作抗心律失常药。 提供了通过增加心脏组织的耐火性来治疗心律失常的方法，以及含有这种铵盐的药物制剂。
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公开(公告)号：US4709043A
公开(公告)日：1987-11-24
申请号：US801702
申请日：1985-11-26
IPC分类号： C07D233/70 , C07D403/10 , C07D521/00 , C07D401/14
CPC分类号： C07D231/12 , C07D233/56 , C07D233/70 , C07D249/08 , C07D403/10
摘要： Novel imidazolonecarbonylarylimidazoles are described having cardiovascular properties, especially as cardiotonic agents in the treatment of congestive heart failure. Pharmaceutical formulations containing such compounds are also provided. Further, a novel process for the preparation of the compounds and intermediates useful thereto of this invention is disclosed.
摘要翻译： 描述了具有心血管特性的新型咪唑烷羰基芳基咪唑，特别是用于治疗充血性心力衰竭的强心剂。 还提供了含有这些化合物的药物制剂。 此外，公开了用于制备本发明有用的化合物和中间体的新方法。
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