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23 条记录 (耗时 0.047 秒)

    Condensed diazepinones and medicaments containing these compounds
    5.
    发明授权
    Condensed diazepinones and medicaments containing these compounds 失效
    浓缩二氮杂酮和含有这些化合物的药物

    公开(公告)号：US5179090A

    公开(公告)日：1993-01-12

    申请号：US779203

    申请日：1991-10-18

    申请人： Klaus Rudolf ,  Wolfhard Engel ,  Wolfgang Eberlein ,  Gunter Trummlitz ,  Gerhard Mihm ,  Henri Doods ,  Norbert Mayer

    发明人： Klaus Rudolf ,  Wolfhard Engel ,  Wolfgang Eberlein ,  Gunter Trummlitz ,  Gerhard Mihm ,  Henri Doods ,  Norbert Mayer

    IPC分类号： C07D487/18 ,  C07D519/00

    CPC分类号： C07D487/18 ,  C07D519/00

    摘要： Condensed diazepinones of general formula I ##STR1## in which]B represents one of the divalent groups ##STR2## X is a .dbd.CH-- group or a nitrogen atom,R represents a lower alkyl radical, which may optionally be further substituted by a phenyl optionally carrying halogen, methyl or methoxy,R.sup.4 and R.sup.5 represent hydrogen, halogen or lower alkyl,R.sup.6 is hydrogen, chlorine or methyl,R.sup.7 and R.sup.8 denote lower alkyl, R.sup.8 also additionally denotes halogen, andm, n, o and p represent the numbers 0, 1, 2 or 3 with the following limitations: the sum of m+n and the sum of o+p each denote the numbers 1, 2 or 3, the sum of n+o and the sum of m+p each denote the numbers 1, 2, 3, 4 or 5, wherein, however, the sum of m+n+o+p must always be greater than 2, andA.sup.1, A.sup.2, A.sup.3 and A.sup.4 denote hydrogen, or, for the case where m, n, o and p each denote the number 1, A.sup.1 and A.sup.2 together or A.sup.3 and A.sup.4 together represent an ethylene bridge,are suitable for the treatment of cholinergically induced spasms and motility disorders of the gastrointestinal tract and in the region of the evacuating bile ducts, for the symptomatic treatment of cystitis and of spasms from urelithiasis, for the treatment of relative incontinence, for the symptomatic treatment of bronchial asthma and bronchitis, and for the treatment of ischaemic heart diseases. The compounds are characterized by good selectivity.

    摘要翻译： （I）其中] + E，crc / B /表示二价基团之一的通式I的缩二氮杂酮类（I）其中一个二价基团（S）（T） V）X是= CH-基或氮原子，R表示低级烷基，其可以任选地被任选地带有卤素，甲基或甲氧基的苯基进一步取代，R4和R5代表氢，卤素或低级烷基，R6 是氢，氯或甲基，R7和R8表示低级烷基，R8还另外表示卤素，m，n，o和p表示数字0,1,2或3，具有以下限制：m + n和 o + p的和表示数字1,2或3，n + o和m + p之和各自表示数字1,2,3,4或5，其中，然而， m + n + o + p必须始终大于2，A1，A2，A3和A4表示氢，或者对于m，n，o和p分别表示数字1，A1和A2一起或A3 和A4一起代表乙烯桥，适合于处理o f胆碱能诱发胃肠道的痉挛和运动障碍以及排空胆管区域，用于膀胱炎和尿毒症痉挛的症状治疗，用于治疗相对失禁，用于支气管哮喘和支气管炎的症状治疗， 并用于治疗缺血性心脏病。 该化合物的特征在于良好的选择性。

    Use of diazepinones for treating disorders of the microcirculation
    8.
    发明授权
    Use of diazepinones for treating disorders of the microcirculation 失效
    二氮嗪酮用于治疗微循环障碍的用途

    公开(公告)号：US5001122A

    公开(公告)日：1991-03-19

    申请号：US353262

    申请日：1989-05-17

    申请人： Wolfgang Eberlein ,  Volker Trach ,  Wolfhard Engel ,  Gerhard Mihm ,  Norbert Mayer ,  Henri Doods ,  Richard Reichl

    发明人： Wolfgang Eberlein ,  Volker Trach ,  Wolfhard Engel ,  Gerhard Mihm ,  Norbert Mayer ,  Henri Doods ,  Richard Reichl

    IPC分类号： C07D243/38 ,  A61K31/00 ,  A61K31/55 ,  A61P9/00 ,  A61P9/08 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

    CPC分类号： A61K31/55 ,  Y10S514/921

    摘要： A method for treating shock in a patient, which comprises administering to the patient a therapeutically effective amount of a diazepinone of the general formula: ##STR1## wherein A represents a 5,11-dihydro-6H-pyrido[2,3-b] [1,4] benzodiazepin-6-one group bound in the 11-position; a 5,10-dihydro-11H-dibenzo [b,e] [1,4] diazepin-11-one group bound in the 5-position; a 5,11-dihydro-10H-pyrido [3-2b] [1-4] benzodiazepin-10-one group bound in the 5-position; a 4,9-dihydro-10H-thieno [3,4-b] [1,5] benzodiazpin-10-one group bound in the 4-position, unsubstituted or substituted at the 1- or 3-position or both in the 1- and 3-position by an alkyl group having from 1 to 4 carbon atoms, or in the 3-positionby chlorine, fluorine or bromine; a 6-11-dihydro-5H-pyrido [2,3-b] [1,5] benzodiazepin-5-one group bound in the 11-position; or a 1-methyl-1,4,9,10-tetrahydropyrrolo-[3,2-b] [1,5] benzodiazepin-10-one group bound in the 4-position, unsubstituted or substituted at the 3-position by methyl or methyl or chlorine;R.sub.1 represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms;R.sub.2 represents an alkyl group having from 1 to 3 carbon atoms; andn and m each represent an integer from 1 to 3.

    摘要翻译： 一种治疗患者休克的方法，其包括向患者施用治疗有效量的通式如下的二氮杂酮：其中A代表5,11-二氢-6H-吡啶并[2,3-b] 结合在11位的[1,4]苯并二氮杂- 5位结合的5,10-二氢-11H-二苯并[b，e] [1,4]二氮杂-11-酮基; 5位结合的5,11-二氢-10H-吡啶并[3-2b] [1-4]苯并二氮杂-10-酮基; 在4-位上结合的未取代或取代的4,9-二氢-10H-噻吩并[3,4-b] [1,5]苯并二氮杂基-10-酮基或在 通过具有1至4个碳原子的烷基或3-，3-位上的氯，氟或溴取代1-和3-位; 在11位结合的6-11-二氢-5H-吡啶并[2,3-b] [1,5]苯并二氮杂-5-基; 或在4-位上结合的1-甲基-1,4,9,10-四氢吡咯并[3,2-b] [1,5]苯并二氮杂-10-酮基，其未被取代或在3位被 甲基或甲基或氯; R1表示氢原子或具有1至3个碳原子的烷基; R2表示具有1至3个碳原子的烷基; n和m各自表示1〜3的整数。