公开(公告)号：US09694301B2

公开(公告)日：2017-07-04

申请号：US14400312

申请日：2012-05-10

申请人： Konstantin Choikhet ,  Klaus Witt

发明人： Konstantin Choikhet ,  Klaus Witt

IPC分类号： B01D15/18 ,  G01N30/32 ,  G01N30/46 ,  G01N27/447 ,  G01N30/72 ,  G01N30/34 ,  G01N30/60

CPC分类号： B01D15/18 ,  G01N27/44704 ,  G01N30/32 ,  G01N30/34 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6095 ,  G01N30/72 ,  G01N2030/322 ,  G01N2030/328

摘要： A sample separation apparatus for separating a liquid sample includes a first separation unit for separating the sample, a first fluid drive for conducting the sample to be separated through the first separation unit, a second separation unit, arranged downstream of the first separation unit, for further separating the sample, a second fluid drive for at least partially conducting the sample through the second separation unit, and a fluidic valve having interfaces fluidically coupled to the first and second fluid drives and being switchable for performing the separation of the sample. The apparatus is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet of the first separation unit and an inlet of the second separation unit or in fluid communication with this fluidic path.

公开(公告)号：US20150059451A1

公开(公告)日：2015-03-05

申请号：US14396938

申请日：2012-04-25

申请人： Klaus Witt ,  Konstantin Choikhet

发明人： Klaus Witt ,  Konstantin Choikhet

IPC分类号： B01D15/12 ,  G01N30/16

CPC分类号： B01D15/12 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N30/16 ,  G01N30/34

摘要： A fluid supply system (150) configured for supplying fluids, the fluid supply system (150) comprising a fluid packet supply unit (180) configured for controlling supply of a sequence (250) of fluid packets (222 to 230), the fluid packets (222 to 230) comprising a packet of first fluid (223) and a packet of second fluid (225), wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid (223) and the packet of second fluid (225), and a phase separation inhibiting unit (190) configured for inhibiting phase separation by inserting an intermediate fluid packet (224) between the packet of first fluid (223) and the packet of second fluid (225) to 230 to 230

摘要翻译： 一种构造成供应流体的流体供应系统（150），所述流体供应系统（150）包括被配置为控制流体包（222至230）的序列（250）的供应的流体包供应单元（180），所述流体包 （222至230），包括第一流体（223）和第二流体（225）的包装，其中所述第一流体和所述第二流体是介质在所述第一流体包之间的直接相互作用时易于相分离 223）和第二流体（225）的分组，以及相分离禁止单元（190），其被配置为通过在第一流体（223）的包和第二流体包之间插入中间流体包（224）来抑制相分离 （225）至230至230

公开(公告)号：US20120198919A1

公开(公告)日：2012-08-09

申请号：US13346092

申请日：2012-01-09

申请人： Klaus Witt ,  Konstantin Choikhet ,  Philip Herzog

发明人： Klaus Witt ,  Konstantin Choikhet ,  Philip Herzog

IPC分类号： G01N11/00

CPC分类号： G01N30/34

摘要： A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range; switching from the first solvent supply line to a second solvent supply line at one of said switching points of time; drawing in a second liquid into the pumping unit via the second solvent supply line.

摘要翻译： 一种用于在液体供应系统中以可控比例计量两种或多种液体并用于供应所得混合物的方法，其中所述液体供应系统包括多个溶剂供应管线，配置阀插入在所述溶剂供应管线之间， 抽吸单元，该方法包括经由第一溶剂供应管线将第一液体引入泵送单元; 确定用于在不同溶剂供应管线之间切换的一个或多个切换点，所述切换点的时间是以在所述切换时间点被供应到所述泵送单元的液体处于预定压力范围内的方式确定的; 在所述切换点之一从第一溶剂供应管线切换到第二溶剂供应管线; 通过第二溶剂供应管线将第二液体吸入泵送单元。

公开(公告)号：US09335309B2

公开(公告)日：2016-05-10

申请号：US14411276

申请日：2012-06-26

申请人： Klaus Witt ,  Konstantin Choikhet

发明人： Klaus Witt ,  Konstantin Choikhet

IPC分类号： G01N33/00 ,  G01N30/80 ,  G01N30/20 ,  G01N27/447 ,  G01N30/06 ,  B01D15/18 ,  G01N30/46 ,  G01N30/60

CPC分类号： G01N30/80 ,  B01D15/1871 ,  G01N27/447 ,  G01N30/06 ,  G01N30/20 ,  G01N30/461 ,  G01N30/6039 ,  G01N2030/208

摘要： A sample separation apparatus includes a fluidic valve including a first inlet fluidically coupled to one of a first fluid drive and a second fluid drive, and a second inlet fluidically coupled to the other of the first fluid drive and the second fluid drive. The fluidic valve includes at least two different sets of storage paths, wherein each set of storage paths comprises a first storage path. The first storage path of a first set of said at least two sets of storage paths has a first volume, and the first storage path of a second set of said at least two sets of storage paths has a second volume different from the first volume. The fluidic valve is configured for selectively switching one set of the least two sets of storage paths to the first inlet and the second inlet.

摘要翻译： 样品分离装置包括流体阀，其包括流体耦合到第一流体驱动器和第二流体驱动器中的一个的第一入口，以及与第一流体驱动器和第二流体驱动器中的另一个流体连接的第二入口。 流体阀包括至少两组不同的存储路径，其中每组存储路径包括第一存储路径。 所述至少两组存储路径的第一组的第一存储路径具有第一卷，并且所述至少两组存储路径的第二组的第一存储路径具有不同于第一卷的第二卷。 流体阀构造成用于选择性地将一组至少两组存储路径切换到第一入口和第二入口。

公开(公告)号：US20120096919A1

公开(公告)日：2012-04-26

申请号：US13378376

申请日：2009-06-30

申请人： Konstantin Choikhet ,  Klaus Witt

发明人： Konstantin Choikhet ,  Klaus Witt

IPC分类号： G01N30/02

CPC分类号： G01N30/86 ,  G01N30/24 ,  G01N30/88

摘要： A liquid chromatography device (200) being controllable for executing a chromatographic method (402) defined by a set of target parameters and by a corresponding target sequence of operation procedures, the device comprising a method execution unit (202) configured for executing the chromatographic method (402) by applying the set of target parameters and by running the corresponding target sequence of operation procedures within the liquid chromatography device (200), a determining unit (204) configured for determining a deviation of an actual result of the chromatographic method (402) from an expected target result, wherein the expected target result of the chromatographic method (402) represents a desired behavior of the liquid chromatography device (200) and wherein the actual result of the chromatographic method (402) is obtained by executing the chromatographic method (402) and represents an actual behavior of the liquid chromatography device (200), and an adjusting unit (206) configured for adjusting at least one operation property of the liquid chromatography device (200) based on the determined deviation to thereby at least partially compensate a difference between the expected target result and the actual result while maintaining the chromatographic method (402) unchanged.

摘要翻译： 可控液相色谱装置（200），用于执行由一组目标参数和相应的目标操作程序定义的色谱方法（402），所述装置包括方法执行单元（202），其被配置为执行色谱法 （402），通过应用所述目标参数集合并且通过在所述液相色谱装置（200）内运行相应的目标操作程序序列来确定所述色谱方法（402）的实际结果的偏差的确定单元（204） ），其中色谱方法（402）的预期目标结果表示液相色谱装置（200）的期望行为，并且其中色谱法（402）的实际结果是通过执行色谱法获得的 （402）并且表示液相色谱装置（200）的实际行为，以及调节单元（206） 根据所确定的偏差设计用于调节液相色谱装置（200）的至少一个操作属性，从而至少部分地补偿预期目标结果与实际结果之间的差异，同时保持色谱方法（402）不变。

公开(公告)号：US08297936B2

公开(公告)日：2012-10-30

申请号：US11900578

申请日：2007-09-12

申请人： Klaus Witt ,  Konstantin Choikhet ,  Alexander Bierbaum

发明人： Klaus Witt ,  Konstantin Choikhet ,  Alexander Bierbaum

IPC分类号： F04B49/10

CPC分类号： G01N30/32 ,  G01N30/34 ,  G01N2030/324 ,  G01N2030/326

摘要： A method for controlling movement of a piston in a metering device is described. The method comprises supplying a fluid by actuating the metering device's piston, wherein compression or expansion of the fluid causes corresponding temperature variations. The method further comprises superposing a corrective movement onto the piston movement, with the corrective movement at least partly compensating for at least one of thermal expansion and contraction of the fluid induced by the temperature variations. In one embodiment, the corrective movement imposed onto the piston movement comprises two components: a reduction (74) of the compression jump (73), and a subsequent increase (75) of the piston's forward displacement rate (71) during a period (76) of time (72).

摘要翻译： 描述了一种用于控制计量装置中活塞运动的方法。 该方法包括通过致动计量装置的活塞来供应流体，其中流体的压缩或膨胀引起相应的温度变化。 该方法还包括将校正运动叠加到活塞运动上，校正运动至少部分地补偿由温度变化引起的流体的热膨胀和收缩中的至少一种。 在一个实施例中，施加到活塞运动上的校正运动包括两个部件：压缩跳跃（73）的减小（74）和在一段时间内的活塞向前移位速率（71）的随后增加（75） ）的时间（72）。

公开(公告)号：US20120216886A1

公开(公告)日：2012-08-30

申请号：US13464309

申请日：2012-05-04

申请人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

发明人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC分类号： F04B49/06 ,  E03B7/07

CPC分类号： F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

摘要： A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

摘要翻译： 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与次级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US20100275678A1

公开(公告)日：2010-11-04

申请号：US12431972

申请日：2009-04-29

申请人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

发明人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC分类号： G01N30/64 ,  F04B49/00 ,  B01D15/08

CPC分类号： F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

摘要： A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

摘要翻译： 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与次级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US09360006B2

公开(公告)日：2016-06-07

申请号：US13464309

申请日：2012-05-04

申请人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

发明人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC分类号： F04B11/00 ,  F04B49/08 ,  B01D15/14 ,  G01N30/32

CPC分类号： F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

摘要： A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

摘要翻译： 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与次级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US08182680B2

公开(公告)日：2012-05-22

申请号：US12431972

申请日：2009-04-29

申请人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

发明人： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC分类号： B01D15/08

CPC分类号： F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

摘要： A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

摘要翻译： 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与二级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。