公开(公告)号：US5376538A

公开(公告)日：1994-12-27

申请号：US160668

申请日：1993-12-02

申请人： Kuniki Kino ,  Junichi Takano ,  Kazuyuki Okamoto ,  Yoshiyuki Kuratsu

发明人： Kuniki Kino ,  Junichi Takano ,  Kazuyuki Okamoto ,  Yoshiyuki Kuratsu

IPC分类号： C12P13/08 ,  C12R1/19

CPC分类号： C12P13/08

摘要： Disclosed is a process for producing L-threonine, which comprises culturing an L-threonine-producing microorganism belonging to the genus Escherichia and having a resistance to at least one of L-phenylalanine and L-leucine in a medium until L-threonine is produced and accumulated in the culture, and recovering L-threonine therefrom.

摘要翻译： 公开了一种L-苏氨酸的制造方法，其包括在培养基中培养属于埃希氏杆菌属的L-苏氨酸生产微生物，并且在培养基中具有对L-苯丙氨酸和L-亮氨酸中的至少一种的抗性，直至产生L-苏氨酸 并在培养物中积累，从其中回收L-苏氨酸。

公开(公告)号：US5474918A

公开(公告)日：1995-12-12

申请号：US282816

申请日：1994-07-29

申请人： Kuniki Kino ,  Kazuyuki Okamoto ,  Yasuya Takeda ,  Yoshiyuki Kuratsu

发明人： Kuniki Kino ,  Kazuyuki Okamoto ,  Yasuya Takeda ,  Yoshiyuki Kuratsu

IPC分类号： C12N1/20 ,  C12P13/06 ,  C12P13/08 ,  C12R1/19 ,  C12P13/04

CPC分类号： C12R1/19 ,  C12P13/06 ,  C12P13/08

摘要： A process for the production of L-threonine by fermentation of Escherichia coli FERM BP-3756 or Escherichia coli FERM BP-4072 and a process for the production of L-isoleucine by the fermentation of Escherichia coli FERM BP-3757 is disclosed. The strains are resistant to purine analogues such as 6-dimethylaminopurine or 6-methylaminopurine.

摘要翻译： 公开了通过大肠杆菌FERM BP-3756或大肠杆菌FERM BP-4072的发酵生产L-苏氨酸的方法和通过大肠杆菌FERM BP-3757的发酵生产L-异亮氨酸的方法。 该菌株对嘌呤类似物如6-二甲基氨基嘌呤或6-甲基氨基嘌呤具有抗性。

公开(公告)号：US5362637A

公开(公告)日：1994-11-08

申请号：US973452

申请日：1992-11-09

申请人： Kuniki Kino ,  Yoshiyuki Kuratsu

发明人： Kuniki Kino ,  Yoshiyuki Kuratsu

IPC分类号： C12P13/06 ,  C12R1/19

CPC分类号： C12P13/06 ,  C12R1/19 ,  Y10S435/849

摘要： Disclosed is a process for producing L-isoleucine which comprises culturing in a medium a microorganism belonging to the genus Escherichia and having resistance to an isoleucine analogue and either ethionine or argonine hydroxamate and an ability to produce L-isoleucine until L-isoleucine is accumulated in the culture, and recovering L-isoleucine therefrom.

摘要翻译： 公开了一种生产L-异亮氨酸的方法，其包括在培养基中培养属于埃希氏杆菌属的微生物并具有对异亮氨酸类似物和乙硫氨酸或氩异羟肟酸的抗性的能力，并产生L-异亮氨酸直到L-异亮氨酸积累的能力 培养，并从中回收L-异亮氨酸。

公开(公告)号：US5275940A

公开(公告)日：1994-01-04

申请号：US748559

申请日：1991-08-22

申请人： Kuniki Kino ,  Kazuhiro Furukawa ,  Yasuhiro Tomiyoshi ,  Yoshiyuki Kuratsu

发明人： Kuniki Kino ,  Kazuhiro Furukawa ,  Yasuhiro Tomiyoshi ,  Yoshiyuki Kuratsu

IPC分类号： C12N1/21 ,  C12P13/22 ,  C12R1/15

CPC分类号： C12P13/227

摘要： Disclosed is a process for producing L-tryptophan which comprises culturing in a medium a microorganism belonging to the genus Corynebacterium or Brevibacterium having resistance to an aminoquinoline derivative or a phenothiazine derivative and an ability to produce L-tryptophan until L-tryptophan is accumulated in the culture and recovering L-tryptophan therefrom.

摘要翻译： 公开了一种生产L-色氨酸的方法，其包括在培养基中培养属于棒状杆菌属的微生物或对氨基喹啉衍生物或吩噻嗪衍生物具有抗性的微生物和产生L-色氨酸的能力，直到L-色氨酸积累在 培养并从中回收L-色氨酸。

公开(公告)号：US20090197303A1

公开(公告)日：2009-08-06

申请号：US12097806

申请日：2006-12-27

申请人： Kuniki Kino ,  Atsushi Noguchi ,  Yuji Nakazawa ,  Makoto Yagasaki

发明人： Kuniki Kino ,  Atsushi Noguchi ,  Yuji Nakazawa ,  Makoto Yagasaki

IPC分类号： C12P21/02 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21

CPC分类号： C12P21/02 ,  C12N9/93

摘要： The present invention provides: a protein having dipeptide-synthesizing activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant transformed with the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity using the transformant or the like; a process for producing a dipeptide using the protein having dipeptide-synthesizing activity; and a process for producing a dipeptide using, as an enzyme source, a culture of a transformant or a microorganism which produces the protein having dipeptide-synthesizing activity or the like.

摘要翻译： 本发明提供：具有二肽合成活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 用重组DNA转化的转化体; 使用转化体等制备具有二肽合成活性的蛋白质的方法; 使用具有二肽合成活性的蛋白质生产二肽的方法; 使用产生具有二肽合成活性的蛋白质的转化体或微生物的培养物作为酶源来生产二肽的方法。

公开(公告)号：US20070218525A1

公开(公告)日：2007-09-20

申请号：US11547491

申请日：2005-03-04

申请人： Kuniki Kino ,  Masaru Sato

发明人： Kuniki Kino ,  Masaru Sato

IPC分类号： C12P1/04

CPC分类号： C07K5/06 ,  C12N9/93 ,  C12P21/02

摘要： The present invention provides a process for producing a dipeptide other than D-alanyl-D-alanine and D-alanyl-D-serine using, as an enzyme source, a culture of a microorganism having the ability to produce a protein having D-alanine-D-alanine ligase activity or a treated matter of the culture, and a process for producing a dipeptide comprising D-amino acid using, as enzyme sources, a culture of a microorganism having the ability to produce the D-amino acid or a treated matter of the culture and a culture of a microorganism having the ability to produce a protein having D-alanine-D-alanine ligase activity or a treated matter of the culture.

摘要翻译： 本发明提供了使用D-丙氨酸-D-丙氨酸和D-丙氨酰-D-丝氨酸以外的二肽的制造方法，其使用具有产生具有D-丙氨酸的蛋白质的能力的微生物的培养物作为酶源 D-丙氨酸连接酶活性或培养物的处理物质，以及使用具有生产D-氨基酸能力的微生物的培养物或经处理的D-氨基酸的生产二氨基酸的方法，所述二肽包含D-氨基酸，作为酶源， 培养物质和具有产生具有D-丙氨酸-D-丙氨酸连接酶活性的蛋白质的能力的微生物的培养物或培养物的处理物质。

公开(公告)号：US4729952A

公开(公告)日：1988-03-08

申请号：US582883

申请日：1984-02-23

申请人： Kiyoji Hattori ,  Yukinobu Kotani ,  Kuniki Kino

发明人： Kiyoji Hattori ,  Yukinobu Kotani ,  Kuniki Kino

IPC分类号： C12P13/14 ,  C12N1/20 ,  C12R1/13 ,  C12R1/15

CPC分类号： C12R1/14 ,  C12P13/14 ,  C12R1/15 ,  Y10S435/84 ,  Y10S435/843

摘要： A process is disclosed for producing L-glutamic acid, the process involves culturing a microorganism belonging to the genus Corynebacterium or Brevibacterium and having both an ability to produce L-glutamic acid and a resistance to .alpha.-naphthoquinoline, an antibiotic inhibiting energy metabolism or a precursor for ubiquinone biosynthesis in a nutrient medium until L-glutamic acid is accumulated in the resulting culture liquor, and recovering the L-glutamic acid therefrom.

公开(公告)号：US07939294B2

公开(公告)日：2011-05-10

申请号：US12442472

申请日：2007-09-25

申请人： Kuniki Kino ,  Youichi Kotanaka ,  Makoto Yagasaki

发明人： Kuniki Kino ,  Youichi Kotanaka ,  Makoto Yagasaki

IPC分类号： C12P21/06

CPC分类号： C12N9/10 ,  C12P21/02

摘要： The present invention provides a protein having dipeptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having dipeptide-synthesizing activity using the transformant, a process for producing a dipeptide using a protein having dipeptide-synthesizing activity, and a process for producing a dipeptide using a culture or the like of a transformant or a microorganism that produces a protein having dipeptide-synthesizing activity as an enzyme source.

摘要翻译： 本发明提供了具有二肽合成活性的蛋白质，编码该蛋白质的DNA，含有该DNA的重组DNA，通过用该重组DNA转化得到的转化体，使用该转化体产生具有二肽合成活性的蛋白质的方法， 使用具有二肽合成活性的蛋白质生产二肽的方法，以及使用产生具有二肽合成活性的蛋白质作为酶源的转化体或微生物的培养物等制备二肽的方法。

公开(公告)号：US07067289B1

公开(公告)日：2006-06-27

申请号：US09665617

申请日：2000-09-19

申请人： Kuniki Kino ,  Tetsuya Abe

发明人： Kuniki Kino ,  Tetsuya Abe

IPC分类号： C12P13/24

CPC分类号： C12P13/04 ,  C12P13/24 ,  C12R1/19

摘要： The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, glycine, L-serine, L-threonine, L-cysteine, L-tyrosine, L-asparagine, L-glutamine, L-lysine, L-histidine, L-arginine, L-aspartic acid and L-glutamic acid and useful as medicament, chemical agent, food material and feed additive at high industrial efficiency, the method comprising culturing a microorganism having an ability to produce the amino acid and having resistance to an aminoquinoline derivative in a medium, producing and accumulating the amino acid in the present invention in the culture, and recovering the amino acid from the culture.

摘要翻译： 本发明提供了选自L-丙氨酸，L-缬氨酸，L-亮氨酸，L-异亮氨酸，L-甲硫氨酸，L-苯丙氨酸，L-脯氨酸，甘氨酸，L-丝氨酸的氨基酸的制备方法 ，L-苏氨酸，L-半胱氨酸，L-酪氨酸，L-天冬酰胺，L-谷氨酰胺，L-赖氨酸，L-组氨酸，L-精氨酸，L-天冬氨酸和L-谷氨酸，可用作药物， 食品原料和饲料添加剂，该方法包括在培养基中培养具有产生氨基酸并具有氨基喹啉衍生物的能力的微生物，在培养物中产生和积累本发明中的氨基酸，以及 从培养物中回收氨基酸。

公开(公告)号：US5919670A

公开(公告)日：1999-07-06

申请号：US99036

申请日：1998-06-18

申请人： Kazuyuki Okamoto ,  Masato Ikeda ,  Kuniki Kino

发明人： Kazuyuki Okamoto ,  Masato Ikeda ,  Kuniki Kino

IPC分类号： C12N1/20 ,  C12P13/04 ,  C12P13/08 ,  C12R1/19

CPC分类号： C12P13/08 ,  C12P13/04 ,  Y10S435/849

摘要： The present invention provides a process for producing an L-amino acid which comprises culturing in a nutrient medium a microorganism which is capable of producing the L-amino acid and which can not grow in a synthetic medium containing said L-amino acid as the sole nitrogen source in an amount of 5 mg/ml or below, allowing the L-amino acid to accumulate in the culture, and recovering the L-amino acid from the culture.