Abstract:
A cryogenic tissue ablation instrument includes an elongate flexible body with a proximal supply port for coupling with a pressurized coolant, a supply lumen in communication with the proximal supply port, and an expandable balloon carried on the elongate body. A dispersion member coupled to the elongate body has an interior lumen in communication with the supply lumen, the dispersion member having one or more coolant dispersion apertures sized and located such that a pressurized flowable coolant will enter the balloon interior in the form of a liquid spray that contacts and provides substantially uniform cooling of the balloon.
Abstract:
Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents
Abstract:
The present invention relates to devices and methods for creating and securing a tissue fold during an endoluminal medical procedure. The devices and methods may be used for folding and securing, for example, a fundus wall onto an esophagus wall. An aspect of the invention includes a two-piece tissue clip configured to be installed through an endoluminal device to secure a tissue fold. The clip includes a female member and a male member configured to engage one another to secure the tissue fold. Another aspect of the invention includes a clipping device comprising a tissue clip magazine. The magazine is configured to hold a plurality of tissue clips and install the plurality of tissue clips in a single actuation of the magazine. A method for using the clipping device together with the tissue clips of the present invention to create and secure a fold of tissue during an endoluminal procedure also is disclosed.
Abstract:
A porous weave of bioabsorbable filaments is encased in an elastic membrane to form a thin-walled stent. The stent is sized to be snugly fitted in the proximate portion of the duodenum of a patient, to induce weight loss by limiting uptake of food passing through the stent. After a predetermined period, the stent degrades and passes from the body without surgical intervention.
Abstract:
A porous weave of bioabsorbable filaments is encased in an elastic membrane to form a thin-walled stent. The stent is sized to be snugly fitted in the proximate portion of the duodenum of a patient, to induce weight loss by limiting uptake of food passing through the stent. After a predetermined period, the stent degrades and passes from the body without surgical intervention.
Abstract:
A stenting system for insertion into the lumen of a body duct or vessel for delivering a therapeutic agent to a treatment site on the duct or vessel. The stenting system includes an a tubular stent member having a lumen there through to allow the passage of material, an outer membrane attached to the stent at least a portion of which is porous to the therapeutic agent to allow the agent to pass to the treatment site, an inner membrane attached to the stent which is nonporous to the therapeutic agent to prevent the agent from entering the lumen of the stent, and a chamber located between the inner and outer membranes for holding the therapeutic agent. The therapeutic agent in the chamber may diffuse through the porous portion of the membrane and be deposited directly on the body site.
Abstract:
Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
Abstract:
A device for accessing tissue within a body lumen comprises an elongated body portion defining a lumen and an anchoring mechanism including an expanding structure on a distal portion of the elongated body portion. The anchoring mechanism moves the expanding structure from an insertion configuration in which the expanding structure is constricted against the device to an operative configuration in a body in which the expanding structure expands away from the device without altering a length of the anchoring mechanism in combination with a control mechanism for selectively engaging the anchoring mechanism.
Abstract:
Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A tissue patch includes a substrate, a tissue implant attached to the substrate, and a protective liner covering at least a portion of the tissue implant. A method includes providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant. The tissue patch is formed into a contracted state and inserted into a lumen containing the lesion. The tissue patch then is positioned in the vicinity of the lesion. After removing the protective liner to reveal the tissue implant, the tissue implant is placed in the lesion.
Abstract:
Described herein are multi-part instrument systems and methods of use. The instrument can include an inner and outer body member where the inner body member is adapted to dock with the outer body member. When docked, driving the outer body member via a manipulation section can control the inner body. In use, an inner body member can be removed and replaced by a different inner body member to change the tool end effector. Alternatively, driving a manipulation section of the inner body member can control the outer body member. The outer body member can be disposable while the inner body member is reusable.