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    Systems and methods for detecting an analyte of interest in a sample using filters and microstructured surfaces
    2.
    发明授权
    Systems and methods for detecting an analyte of interest in a sample using filters and microstructured surfaces 有权
    使用过滤器和微结构化表面检测样品中感兴趣的分析物的系统和方法

    公开(公告)号：US09470612B2

    公开(公告)日：2016-10-18

    申请号：US14122373

    申请日：2012-06-26

    申请人： Raj Rajagopal ,  Kurt J. Halverson ,  Ramasubramani Kuduva Raman Thanumoorthy

    发明人： Raj Rajagopal ,  Kurt J. Halverson ,  Ramasubramani Kuduva Raman Thanumoorthy

    IPC分类号： G01N1/40 ,  B01L3/00 ,  G01N15/04 ,  C12Q1/04

    CPC分类号： G01N1/4077 ,  B01L3/5021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2400/0409 ,  C12Q1/04 ,  G01N15/042 ,  G01N2001/4083 ,  G01N2001/4088

    摘要： Systems and methods for detecting an analyte of interest in a sample. The system can include a first container comprising a filter portion. The filter portion can include a filter comprising a filtrand of the sample on a first side of the filter. The system can further include a second container comprising the filter portion coupled to a detection portion comprising a microstructured surface. The method can include providing the first container, coupling the filter portion to the detection portion to form the second container where the first side of the filter faces the microstructured surface, and centrifuging the second container toward the microstructured surface. The method can further include inverting the second container after centrifuging to decant the supernatant from the detection portion, such that a concentrate comprising a sediment of the sample is retained in the microstructured surface, which can be interrogated for an analyte of interest.

    摘要翻译： 用于检测样品中感兴趣的分析物的系统和方法。 该系统可以包括包括过滤器部分的第一容器。 过滤器部分可以包括在过滤器的第一侧上包括样品的过滤器的过滤器。 该系统还可以包括第二容器，其包括耦合到包括微结构化表面的检测部分的过滤器部分。 该方法可以包括提供第一容器，将过滤部分连接到检测部分，以形成第二容器，其中过滤器的第一侧面向微结构化表面，并将第二容器离心到微结构化表面。 该方法还可包括在离心后将第二容器倒置以从检测部分倾析上清液，使得包含样品沉淀物的浓缩物保留在微结构化表面中，该微结构化表面可被询问用于感兴趣的分析物。

    Sample preparation container and method
    4.
    发明授权
    Sample preparation container and method 有权
    样品制备容器和方法

    公开(公告)号：US08647574B2

    公开(公告)日：2014-02-11

    申请号：US12743252

    申请日：2008-11-19

    申请人： Kurt J. Halverson ,  Stephen C. P. Joseph ,  Raj Rajagopal ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati ,  Daniel E. Siltberg ,  Paul J. Cobian ,  Theresa J. Gerten

    发明人： Kurt J. Halverson ,  Stephen C. P. Joseph ,  Raj Rajagopal ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati ,  Daniel E. Siltberg ,  Paul J. Cobian ,  Theresa J. Gerten

    IPC分类号： G01N15/06

    CPC分类号： G01N1/38 ,  G01N1/4077 ,  G01N2001/4088

    摘要： A system and method for preparing and collecting samples for analyte testing. The system can include a sample preparation system and a sample collection system coupled to the sample preparation system. The sample preparation system can include at least one of a deformable self-supporting receptacle comprising a reservoir and a freestanding receptacle comprising a reservoir. The reservoir can be adapted to contain a liquid composition. The sample collection system can be positioned in fluid communication with a reservoir of the sample preparation system, and can be adapted to capture an analyte of interest. The method can include providing a fluid path defined at least partially by the sample preparation system and the sample collection system, positioning the liquid composition in a reservoir of the sample preparation system, and moving at least a portion of the liquid composition in the fluid path to the sample collection system.

    摘要翻译： 用于制备和收集样品用于分析物测试的系统和方法。 该系统可以包括与样品制备系统耦合的样品制备系统和样品收集系统。 样品制备系统可以包括可变形的自支撑容器中的至少一个，其包括储存器和包括储存器的独立容器。 储存器可以适于容纳液体组合物。 样品收集系统可以定位成与样品制备系统的储存器流体连通，并且可以适于捕获感兴趣的分析物。 该方法可以包括提供至少部分地由样品制备系统和样品收集系统限定的流体路径，将液体组合物定位在样品制备系统的储存器中，并且将至少一部分液体组合物移动到流体路径 到采样系统。

    METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES
    5.
    发明申请
    METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES 审中-公开
    方法，加工样品的工具和系统

    公开(公告)号：US20110318814A1

    公开(公告)日：2011-12-29

    申请号：US13142292

    申请日：2009-12-30

    申请人： Manjiri T. Kshirsagar ,  Kurt J. Halverson ,  Raj Rajagopal

    发明人： Manjiri T. Kshirsagar ,  Kurt J. Halverson ,  Raj Rajagopal

    IPC分类号： C12N7/02 ,  C12N1/20 ,  C12N1/14 ,  C12N3/00 ,  C12N1/16 ,  C12N1/10 ,  C12N1/12

    CPC分类号： G01N1/4077 ,  C12M47/04 ,  C12Q1/24 ,  G01N1/405 ,  G01N33/1866 ,  G01N2001/4088

    摘要： A method for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the method including the steps of providing a receptacle, the receptacle configured to allow filtering of the sample and to reversibly contain the sample and a concentration agent; adding the sample to the receptacle, wherein a microorganism-bound composition will be formed in the receptacle, the microorganism-bound composition including concentration agent-bound microorganisms and sample matrix; and filtering the microorganism-bound composition through a filter to collect the concentration agent-bound microorganisms on the filter, wherein the filter has an average pore size that is greater than the average size of the microorganisms. Kits and systems are also disclosed herein.

    摘要翻译： 一种用于从样品中分离微生物的方法，所述样品包括样品基质和微生物，所述方法包括提供容器的步骤，所述容器被配置为允许样品过滤并且可逆地容纳样品和浓缩剂; 将样品加入到容器中，其中将在容器中形成微生物结合的组合物，微生物结合的组合物包括与浓度剂结合的微生物和样品基质; 并通过过滤器过滤微生物结合的组合物以收集过滤器上与浓度剂结合的微生物，其中过滤器的平均孔径大于微生物的平均尺寸。 本文还公开了套件和系统。

    SAMPLE PREPARATION CONTAINER AND METHOD
    6.
    发明申请
    SAMPLE PREPARATION CONTAINER AND METHOD 有权
    样品制备容器和方法

    公开(公告)号：US20100248215A1

    公开(公告)日：2010-09-30

    申请号：US12743449

    申请日：2008-11-19

    申请人： Kurt J. Halverson ,  Stephen C.P. Joseph ,  Raj Rajagopal ,  Matthew D. Reier ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati

    发明人： Kurt J. Halverson ,  Stephen C.P. Joseph ,  Raj Rajagopal ,  Matthew D. Reier ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati

    IPC分类号： C12M1/34 ,  C12N1/00 ,  C12N7/00 ,  G01N33/53 ,  C12Q1/70 ,  C12Q1/02 ,  G01N27/26 ,  C12Q1/68

    CPC分类号： G01N1/38

    摘要： A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.

    摘要翻译： 用于制备和递送样品以进行分析物测试的系统和方法。 该系统可以包括与样品制备系统耦合的样品制备系统和样品递送系统。 样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。 样品输送系统可以包括定位成与储存器流体连通的阀，并适于控制样品从样品制备系统中的去除。 该方法可以包括向可变形的自支撑容器施加压力，以经由样品输送系统从样品制备系统移除样品。

    Sample preparation container and method
    8.
    发明授权
    Sample preparation container and method 有权
    样品制备容器和方法

    公开(公告)号：US08569072B2

    公开(公告)日：2013-10-29

    申请号：US12743449

    申请日：2008-11-19

    申请人： Kurt J. Halverson ,  Stephen C. P. Joseph ,  Raj Rajagopal ,  Matthew D. Reier ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati

    发明人： Kurt J. Halverson ,  Stephen C. P. Joseph ,  Raj Rajagopal ,  Matthew D. Reier ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati

    IPC分类号： G01N1/00

    CPC分类号： G01N1/38

    摘要： A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.

    摘要翻译： 用于制备和递送样品以进行分析物测试的系统和方法。 该系统可以包括与样品制备系统耦合的样品制备系统和样品递送系统。 样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。 样品输送系统可以包括定位成与储存器流体连通的阀，并适于控制样品从样品制备系统中的去除。 该方法可以包括向可变形的自支撑容器施加压力，以经由样品输送系统从样品制备系统移除样品。

    SAMPLE PREPARATION CONTAINER AND METHOD
    9.
    发明申请
    SAMPLE PREPARATION CONTAINER AND METHOD 有权
    样品制备容器和方法

    公开(公告)号：US20100248216A1

    公开(公告)日：2010-09-30

    申请号：US12743459

    申请日：2008-11-19

    申请人： Kurt J. Halverson ,  Stephen C.P. Joseph ,  Raj Rajagopal ,  Matthew D. Reier ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati

    发明人： Kurt J. Halverson ,  Stephen C.P. Joseph ,  Raj Rajagopal ,  Matthew D. Reier ,  David J. Velasquez ,  Cynthia D. Zook ,  Sailaja Chandrapati

    IPC分类号： C12Q1/70 ,  C12M1/34 ,  C12Q1/02 ,  C12Q1/68

    CPC分类号： G01N1/38 ,  B01L3/505 ,  Y10T436/25

    摘要： A system and method for preparing and analyzing samples. The system can include a sample preparation system and a sample detection system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample detection system can be positioned in fluid communication with the reservoir, and can be adapted to analyze a sample of the liquid composition for an analyte of interest. The system can further include a fluid path defined at least partially by the reservoir and the sample detection system. The method can include applying pressure to the deformable self-supporting receptacle to move a sample of the liquid composition in the fluid path to the sample detection system, and analyzing the sample for the analyte of interest with the sample detection system.

    摘要翻译： 一种用于准备和分析样品的系统和方法。 该系统可以包括样品制备系统和与样品制备系统耦合的样品检测系统。 样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。 样品检测系统可以定位成与储存器流体连通，并且可以适于分析用于感兴趣的分析物的液体组合物的样品。 该系统还可以包括至少部分地由储存器和样本检测系统限定的流体路径。 该方法可以包括向可变形的自支撑容器施加压力以将流体路径中的液体组合物的样品移动到样品检测系统，并且用样品检测系统分析样品的感兴趣的分析物。