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公开(公告)号:US10896388B2
公开(公告)日:2021-01-19
申请号:US16221416
申请日:2018-12-14
申请人: Kyler Cooper , Jessica Emily Dolezal , Andrew Duguay , Alexander C. Elek , Danielle Marceau , Richard Wagner
发明人: Kyler Cooper , Jessica Emily Dolezal , Andrew Duguay , Alexander C. Elek , Danielle Marceau , Richard Wagner
摘要: The present invention relates to systems and methods for model generation. The model is generated by selecting indicators that are relevant to the model, determining a strength score for each of the indicators, ranking the indicators by their strength scores, and bucketizing the indicators. Different permutations of the indicators are then selected for modeling in parallel. The model results are compared, and the ‘best’ model (most historically accurate) is selected for display within a report.
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公开(公告)号:US20190188612A1
公开(公告)日:2019-06-20
申请号:US16221416
申请日:2018-12-14
申请人: Kyler Cooper , Jessica Emily Dolezal, II , Andrew Duguay , Alexander C. Elek , Danielle Marceau , Richard Wagner
发明人: Kyler Cooper , Jessica Emily Dolezal, II , Andrew Duguay , Alexander C. Elek , Danielle Marceau , Richard Wagner
CPC分类号: G06Q10/04 , G06N20/00 , G06Q10/063 , G06Q10/067
摘要: The present invention relates to systems and methods for model generation. The model is generated by selecting indicators that are relevant to the model, determining a strength score for each of the indicators, ranking the indicators by their strength scores, and bucketizing the indicators. Different permutations of the indicators are then selected for modeling in parallel. The model results are compared, and the ‘best’ model (most historically accurate) is selected for display within a report
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公开(公告)号:US07989395B2
公开(公告)日:2011-08-02
申请号:US11584880
申请日:2006-10-23
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
IPC分类号: C40B50/16
CPC分类号: C12N15/1068 , C07H21/00
摘要: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供了通过筛选包括编码寡核苷酸标签的分子文库来鉴定感兴趣的化合物的方法。
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公开(公告)号:US20080015339A1
公开(公告)日:2008-01-17
申请号:US11890645
申请日:2007-08-06
申请人: Dasa Lipovsek , Richard Wagner , Robert Kuimelis
发明人: Dasa Lipovsek , Richard Wagner , Robert Kuimelis
IPC分类号: C07K14/78
CPC分类号: C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译: 本文公开了包含免疫球蛋白折叠并且可以用作支架的蛋白质。 本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。
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公开(公告)号:US20070173973A1
公开(公告)日:2007-07-26
申请号:US11338172
申请日:2006-01-24
申请人: Richard Wagner
发明人: Richard Wagner
IPC分类号: G06F19/00
CPC分类号: B62D57/032
摘要: A robot having three or more pairs of legs can be walked along the surface of a space vehicle in zero gravity using a pair-wise gait of the robot's feet by which a clean-lifting adhesive fixes each foot of the robot to the space vehicle's surface by a pre-load force that is less than the adhesive's pull-off force. The gait method is to opposing legs of the robot simultaneously, one pair at a time. The legs are moved and then lowered back to the vehicle's surface and forced against the vehicle surface by a pre-load force. The adhesive provides a pull-off force greater than the preload force.
摘要翻译: 具有三对或更多对的腿的机器人可以使用机器人脚的成对步态在零重力下沿着空间车辆的表面行走,其中清洁提升粘合剂将机器人的每一脚固定到空间车辆的表面 通过小于粘合剂剥离力的预加载力。 步态方法是同时对置机器人的腿部,一次一对。 腿被移动,然后下降回车辆的表面并且通过预加载力而被迫抵靠车辆表面。 粘合剂提供大于预紧力的拉力。
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公开(公告)号:US07144077B2
公开(公告)日:2006-12-05
申请号:US11043834
申请日:2005-01-26
申请人: Rainer Grimm , Thomas Becher , Richard Wagner
发明人: Rainer Grimm , Thomas Becher , Richard Wagner
CPC分类号: B60J7/024
摘要: A mechanism for a sun roof has at least one guide rail, a lifting slide that can be moved along the guide rail, and a guide slide that can be locked in the guide rail in an initial position. The guide slide can be moved in the guide rail once the guide slide is unlocked. A cover holder is coupled to the lifting slide and the guide slide in such a way that the cover can be moved between a closed position and an opened position.
摘要翻译: 用于太阳屋顶的机构具有至少一个导轨,可沿着导轨移动的升降滑块和可在初始位置被锁定在导轨中的导向滑块。 一旦导向滑块解锁,导轨滑块就可以在导轨上移动。 盖保持器以使得盖可以在关闭位置和打开位置之间移动的方式联接到提升滑块和引导滑动件。
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公开(公告)号:US20060149521A1
公开(公告)日:2006-07-06
申请号:US11274682
申请日:2005-11-14
申请人: John Baxter , Beatrice Darimont , Weijun Feng , Robert Fletterick , Peter Kushner , Richard Wagner , Brian West , Keith Yamamoto
发明人: John Baxter , Beatrice Darimont , Weijun Feng , Robert Fletterick , Peter Kushner , Richard Wagner , Brian West , Keith Yamamoto
CPC分类号: G01N33/6875 , G01N2500/20 , H01L21/3065 , H01L21/314 , H01L29/6659
摘要: The present invention comprises cocrystal of a nuclear receptor comprising a molecule bound to the coactivator binding site of said nuclear receptor. The present invention further comprises a machine-readable data storage medium encoded with machine readable data corresponding to the structure coordinates of amino acids of a nuclear receptor coactivator binding site which, when using a machine programmed with instructions for using said data, is capable of displaying a graphical three-dimensional representation of a molecular complex of a compound bound to a nuclear receptor coactivator binding site.
摘要翻译: 本发明包括核受体的共晶体,其包含与所述核受体的共激活因子结合位点结合的分子。 本发明还包括一种机器可读数据存储介质,其被编码有对应于核受体共激活剂结合位点的氨基酸的结构坐标的机读数据,当使用编程有用于使用所述数据的指令的机器时,能够显示 与核受体共激活子结合位点结合的化合物的分子复合物的图形三维表示。
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公开(公告)号:US5503798A
公开(公告)日:1996-04-02
申请号:US228684
申请日:1994-04-18
IPC分类号: C22C14/00
CPC分类号: C22C14/00 , F05C2201/021 , F05C2201/043
摘要: A multiphase, high-temperature material contains an intermetallic base alloy of the Ti.sub.3 Al type, which is intended especially for use in heat engines such as internal combustion engines, gas turbines and aircraft engines. The material contains from 44 to 73 atom % titanium, from 19 to 35 atom % aluminum, from 2 to 6 atom % silicon, and from 5 to 15 atom % niobium. The desired microstructure is attained by heat treating the alloy at between 800.degree. and 1100.degree. C.
摘要翻译: 多相高温材料含有Ti3Al型金属间基体合金,其特别用于内燃机,燃气轮机和飞机发动机等发动机。 该材料含有44至73原子%的钛,19至35原子%的铝,2至6原子%的硅和5至15原子%的铌。 所需的微观结构是通过在800〜1100℃之间热处理合金而实现的。
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公开(公告)号:US5117868A
公开(公告)日:1992-06-02
申请号:US441000
申请日:1989-11-22
申请人: Richard Wagner
发明人: Richard Wagner
CPC分类号: F15B20/00 , B64C13/40 , F16K31/42 , Y10T137/86582 , Y10T137/86614
摘要: Pilot-controlled directional valve having two positions, an admitting position and a closing position for a hydraulic user device, such closing position can be obtained independently from the presence of a supplied hydraulic pressure.
摘要翻译: 具有两个位置的先导控制换向阀,用于液压用户装置的允许位置和关闭位置,这种关闭位置可以独立于所提供的液压的存在而获得。
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公开(公告)号:US08598089B2
公开(公告)日:2013-12-03
申请号:US13040674
申请日:2011-03-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
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