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公开(公告)号:US20080293673A1
公开(公告)日:2008-11-27
申请号:US12108008
申请日:2008-04-23
申请人: Kyoko MIURA , Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
发明人: Kyoko MIURA , Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
IPC分类号: A61K31/7008 , A61Q19/00
摘要: The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external preparation containing the same: wherein R1 is a hydrogen atom or an alkyl group having 2 to 18 carbon atoms; R2, R3, and R4 are hydrogen atoms or acyl groups having 2 to 18 carbon atoms and may be all the same or different from others; the steric structure at position 1 may be α or β; provided that R1, R2, R3, and R4 must not be all hydrogen atoms.It is intended to provide an easily available hyaluronic acid production promoting agent and a skin external preparation whereby the production of hyaluronic acid can be promoted in the skin and thus the skin can be maintained in a vital and moist state so that it is expected that the human skin can be prevented from age.
摘要翻译: 本发明涉及由下式(1)表示的N-乙酰氨基葡糖衍生物和含有它的透明质酸生产促进剂和含有它们的皮肤外用制剂:其中R1是氢原子或具有2个 至18个碳原子; R2,R3和R4是氢原子或具有2至18个碳原子的酰基,并且可以全部相同或不同; 位置1的空间结构可以是α或β; 条件是R1,R2,R3和R4不能全部是氢原子。 旨在提供容易获得的透明质酸生产促进剂和皮肤外用制剂,由此可以在皮肤中促进透明质酸的生产,从而可以将皮肤保持在重要和潮湿的状态,因此预期 可以防止人体皮肤老化。
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公开(公告)号:US07393937B2
公开(公告)日:2008-07-01
申请号:US10531176
申请日:2003-07-25
申请人: Kyoko Miura , Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
发明人: Kyoko Miura , Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
摘要: The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external preparation containing the same: wherein R1 is a hydrogen atom or an alkyl group having 2 to 18 carbon atoms; R2, R3, and R4 are hydrogen atoms or acyl groups having 2 to 18 carbon atoms and may be all the same or different from others; the steric structure at position 1 may be α or β; provided that R1, R2, R3, and R4 must not be all hydrogen atoms. It is intended to provide an easily available hyaluronic acid production promoting agent and a skin external preparation whereby the production of hyaluronic acid can be promoted in the skin and thus the skin can be maintained in a vital and moist state so that it is expected that the human skin can be prevented from age.
摘要翻译: 本发明涉及由下式(1)表示的N-乙酰氨基葡糖衍生物和含有它的透明质酸生产促进剂和含有它们的皮肤外用制剂:其中R 1是 氢原子或碳原子数2〜18的烷基; R 2,R 3和R 4是氢原子或具有2至18个碳原子的酰基,并且可以是全部相同或不同的 来自别人 位置1的空间结构可以是α或β; 条件是R 1,R 2,R 3和R 4不能都是氢原子。 旨在提供容易获得的透明质酸生产促进剂和皮肤外用制剂,由此可以在皮肤中促进透明质酸的生产,从而可以将皮肤保持在重要和潮湿的状态,因此预期 可以防止人体皮肤老化。
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公开(公告)号:US20060020127A1
公开(公告)日:2006-01-26
申请号:US10531176
申请日:2003-07-25
申请人: Kyoko Miura , Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
发明人: Kyoko Miura , Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
摘要: The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external preparation containing the same: wherein R1 is a hydrogen atom or an alkyl group having 2 to 18 carbon atoms; R2, R3, and R4 are hydrogen atoms or acyl groups having 2 to 18 carbon atoms and may be all the same or different from others; the steric structure at position 1 may be α or β; provided that R1, R2, R3, and R4 must not be all hydrogen atoms. It is intended to provide an easily available hyaluronic acid production promoting agent and a skin external preparation whereby the production of hyaluronic acid can be promoted in the skin and thus the skin can be maintained in a vital and moist state so that it is expected that the human skin can be prevented from age.
摘要翻译: 本发明涉及由下式(1)表示的N-乙酰氨基葡糖衍生物和含有它的透明质酸生产促进剂和含有它们的皮肤外用制剂:其中R 1是 氢原子或碳原子数2〜18的烷基; R 2,R 3和R 4是氢原子或具有2至18个碳原子的酰基,并且可以是全部相同或不同的 来自别人 位置1的空间结构可以是α或β; 条件是R 1,R 2,R 3和R 4不能都是氢原子。 旨在提供容易获得的透明质酸生产促进剂和皮肤外用制剂,由此可以在皮肤中促进透明质酸的生产,从而可以将皮肤保持在重要和潮湿的状态,因此预期 可以防止人体皮肤老化。
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公开(公告)号:US20050002879A1
公开(公告)日:2005-01-06
申请号:US10473293
申请日:2002-03-11
申请人: Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
发明人: Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
IPC分类号: A61K8/00 , A61K8/31 , A61K8/35 , A61K8/60 , A61K8/67 , A61K31/00 , A61K31/07 , A61K31/203 , A61K31/40 , A61K31/42 , A61K31/7008 , A61P17/16 , A61Q19/00 , A61Q19/08 , A61K7/135 , A61K31/015
CPC分类号: A61K31/7008 , A61K8/31 , A61K8/35 , A61K8/60 , A61K8/671 , A61K31/00 , A61K31/07 , A61K31/203 , A61K31/40 , A61K31/42 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要: The external skin care composition of the present invention comprises N-acetylglucosamine and at least one member selected from the group consisting of retinoid and pro-vitamin A. The external skin care composition of the present invention has an effect of promoting the production of epidermal hyaluronic acid and can retain firmness and moisture of the skin.
摘要翻译: 本发明的外用护肤组合物含有N-乙酰氨基葡萄糖和选自维生素A和维生素A的至少一种。本发明的外用护肤组合物具有促进表皮透明质酸的生产的作用 酸,可以保持皮肤的紧致和湿润。
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公开(公告)号:US20080287393A1
公开(公告)日:2008-11-20
申请号:US12016911
申请日:2008-01-18
申请人: Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
发明人: Tetsuya Sayo , Shingo Sakai , Shintaro Inoue
CPC分类号: A61K31/7008 , A61K8/31 , A61K8/35 , A61K8/60 , A61K8/671 , A61K31/00 , A61K31/07 , A61K31/203 , A61K31/40 , A61K31/42 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要: The external skin care composition of the present invention comprises N-acetylglucosamine and at least one member selected from the group consisting of retinoid and pro-vitamin A.The external skin care composition of the present invention has an effect of promoting the production of epidermal hyaluronic acid and can retain firmness and moisture of the skin.
摘要翻译: 本发明的外用护肤组合物含有N-乙酰氨基葡萄糖和选自维生素A和维生素A的至少一种。本发明的外用护肤组合物具有促进表皮透明质酸的生产的作用 酸,可以保持皮肤的紧致和湿润。
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公开(公告)号:US20070141010A1
公开(公告)日:2007-06-21
申请号:US10588310
申请日:2005-02-03
申请人: Kyoko Miura , Akinori Haratake , Shingo Sakai
发明人: Kyoko Miura , Akinori Haratake , Shingo Sakai
IPC分类号: A61K8/73
摘要: An antiwrinkle agent which is highly effective in alleviating wrinkles caused by the photoaging. The present invention relates to an antiwrinkle agent comprising an N-acetylglucosamine organic acid ester represented by the following general formula (1): wherein R is a linear or branched acyl group having 2 to 18 carbon atoms and the configuration in the 1-position may be either α-form or β-form.
摘要翻译: 一种抗皱消炎剂,其有效减轻由光老化引起的皱纹。 本发明涉及包含由以下通式(1)表示的N-乙酰氨基葡糖有机酸酯的抗皱皱剂:其中R是具有2至18个碳原子的直链或支链酰基,并且1位上的构型可以 可以是α型或β型。
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7.
公开(公告)号:US09056096B2
公开(公告)日:2015-06-16
申请号:US13701702
申请日:2011-06-03
申请人: Hiroyuki Yoshida , Shintaro Inoue , Shingo Sakai , Aya Nagaoka
发明人: Hiroyuki Yoshida , Shintaro Inoue , Shingo Sakai , Aya Nagaoka
IPC分类号: G01N33/53 , A61K39/395 , A61K8/42 , A61K8/44 , A61K8/49 , A61K31/365 , A61K31/4015 , A61K31/5415 , A61K31/7088 , A61K31/713 , A61K48/00 , A61Q19/08 , C07K14/47 , C07K16/40 , C12N15/113 , G01N33/50 , A61K31/16 , A61K31/198 , A61K31/7048 , C07K7/08 , C07K16/18 , C12Q1/02 , A61K8/64 , A61K8/73 , A61K31/728 , A61K38/00
CPC分类号: C07K16/40 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/4913 , A61K8/498 , A61K8/602 , A61K8/606 , A61K8/64 , A61K8/735 , A61K9/0014 , A61K31/16 , A61K31/198 , A61K31/35 , A61K31/365 , A61K31/40 , A61K31/4015 , A61K31/5415 , A61K31/7048 , A61K31/7088 , A61K31/713 , A61K31/728 , A61K38/00 , A61K39/3955 , A61K48/005 , A61K2800/782 , A61Q19/007 , A61Q19/08 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/34 , C12N9/2474 , C12N15/113 , C12N15/1137 , C12N15/52 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12Q1/025 , G01N33/5023 , G01N2400/40 , G01N2500/10
摘要: The present invention is directed to KIAA1199, which is a novel factor involved in decomposition of hyaluronic acid, and to use thereof. More specifically, the invention is directed to a hyaluronic acid decomposition-promoting agent containing the KIAA1199 gene and a protein encoded by the gene; to a hyaluronic acid decomposition-inhibiting agent characterized by inhibiting the activity or expression thereof (including an siRNA or a monoclonal antibody); and to a method for screening a novel hyaluronic acid decomposition-controlling agent, in which the method contains employing the expression of KIAA1199 as an index.
摘要翻译: 本发明涉及KIAA1199,它是涉及透明质酸分解的新颖因素及其应用。 更具体地,本发明涉及含有KIAA1199基因和由该基因编码的蛋白质的透明质酸分解促进剂; 特征在于抑制其活性或表达(包括siRNA或单克隆抗体)的透明质酸分解抑制剂; 以及用于筛选新型透明质酸分解控制剂的方法,其中该方法包含使用KIAA1199的表达作为指标。
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公开(公告)号:US20130095110A1
公开(公告)日:2013-04-18
申请号:US13701702
申请日:2011-06-03
申请人: Hiroyuki Yoshida , Shintaro Inoue , Shingo Sakai , Aya Nagaoka
发明人: Hiroyuki Yoshida , Shintaro Inoue , Shingo Sakai , Aya Nagaoka
IPC分类号: A61K39/395 , A61K31/5415 , A61K31/4015 , C12Q1/02 , A61K31/16 , A61K31/7048 , C07K16/18 , C07K7/08 , A61K31/713 , A61K31/198
CPC分类号: C07K16/40 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/4913 , A61K8/498 , A61K8/602 , A61K8/606 , A61K8/64 , A61K8/735 , A61K9/0014 , A61K31/16 , A61K31/198 , A61K31/35 , A61K31/365 , A61K31/40 , A61K31/4015 , A61K31/5415 , A61K31/7048 , A61K31/7088 , A61K31/713 , A61K31/728 , A61K38/00 , A61K39/3955 , A61K48/005 , A61K2800/782 , A61Q19/007 , A61Q19/08 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/34 , C12N9/2474 , C12N15/113 , C12N15/1137 , C12N15/52 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12Q1/025 , G01N33/5023 , G01N2400/40 , G01N2500/10
摘要: The present invention is directed to KIAA1199, which is a novel factor involved in decomposition of hyaluronic acid, and to use thereof. More specifically, the invention is directed to a hyaluronic acid decomposition-promoting agent containing the KIAA1199 gene and a protein encoded by the gene; to a hyaluronic acid decomposition-inhibiting agent characterized by inhibiting the activity or expression thereof (including an siRNA or a monoclonal antibody); and to a method for screening a novel hyaluronic acid decomposition-controlling agent, in which the method contains employing the expression of KIAA1199 as an index.
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公开(公告)号:US07940071B2
公开(公告)日:2011-05-10
申请号:US11580069
申请日:2006-10-13
申请人: Shingo Sakai
发明人: Shingo Sakai
CPC分类号: G01R31/31725
摘要: A semiconductor device is provided. The semiconductor devices includes a first and second differential pair to which first and second differential input signals are input. The first and second differential pairs are connected to N (N is an integer greater than 1) current sources through N switch pairs. Switches on one side of said N switch pairs are each connected at one end thereof to one of the N current sources and each of the switches on the one side of said N switch pairs are commonly connected at the other end thereof to the first or the second differential pairs. Control signals are connected to control terminals of said N switch pairs, so that a pattern is applied to the N switch pairs. The operation of the current sources can be confirmed by a functional test based on output values from the first and second differential pairs.
摘要翻译: 提供半导体器件。 半导体器件包括输入第一和第二差分输入信号的第一和第二差分对。 第一和第二差分对通过N个开关对连接到N(N是大于1的整数)电流源。 所述N个开关对的一侧上的开关各自在其一端连接到N个电流源中的一个,并且所述N个开关对的一侧上的每个开关在其另一端共同连接到第一或 第二差分对。 控制信号连接到所述N个开关对的控制端子,以便将模式应用于N个开关对。 可以通过基于来自第一和第二差分对的输出值的功能测试来确认电流源的操作。
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10.
公开(公告)号:US07401276B2
公开(公告)日:2008-07-15
申请号:US11315595
申请日:2005-12-23
CPC分类号: G01R31/3187 , G01R31/317 , G01R31/31715 , G01R31/31716
摘要: A semiconductor device includes an output path; an input path; and a test signal generating circuit. The test signal generating circuit generates an input test data signal by changing at least one of an amplitude and a phase of an output test data signal which is generated from a test data in the semiconductor device and transferred on the output path, and supplies the input test data signal onto the input path. The output path and the input path are tested by using the output test data signal and the input test data signal, respectively.
摘要翻译: 半导体器件包括输出路径; 输入路径 和测试信号发生电路。 测试信号产生电路通过改变从半导体器件中的测试数据产生并在输出路径上传送的输出测试数据信号的幅度和相位中的至少一个来产生输入测试数据信号,并将输入 测试数据信号到输入路径上。 通过使用输出测试数据信号和输入测试数据信号来测试输出路径和输入路径。
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