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公开(公告)号：US09790521B2
公开(公告)日：2017-10-17
申请号：US13428585
申请日：2012-03-23
申请人： Larry Cameron Anthony , Hongxian He , Lixuan Lisa Huang , Daniel P. Okeefe , Arthur Leo Kruckeberg , Yougen Li , Lori Ann Maggio-Hall , Jessica McElvain , Mark J. Nelson , Ranjan Patnaik , Steven Cary Rothman
发明人： Larry Cameron Anthony , Hongxian He , Lixuan Lisa Huang , Daniel P. Okeefe , Arthur Leo Kruckeberg , Yougen Li , Lori Ann Maggio-Hall , Jessica McElvain , Mark J. Nelson , Ranjan Patnaik , Steven Cary Rothman
CPC分类号： C12P7/16 , C12N1/38 , C12N9/0006 , C12N15/81 , C12N15/815 , C12P7/42 , Y02E50/10 , Y02P20/52
摘要： Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
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公开(公告)号：US20130071898A1
公开(公告)日：2013-03-21
申请号：US13428585
申请日：2012-03-23
申请人： LARRY CAMERON ANTHONY , Hongxian He , Lixuan Lisa Huang , Daniel P. Okeefe , Arthur Leo Kruckeberg , Yougen Li , Lori Ann Maggio-Hall , Jessica Mcelvain , Mark J. Nelson , Ranjan Patnaik , Steven Cary Rothman
发明人： LARRY CAMERON ANTHONY , Hongxian He , Lixuan Lisa Huang , Daniel P. Okeefe , Arthur Leo Kruckeberg , Yougen Li , Lori Ann Maggio-Hall , Jessica Mcelvain , Mark J. Nelson , Ranjan Patnaik , Steven Cary Rothman
CPC分类号： C12P7/16 , C12N1/38 , C12N9/0006 , C12N15/81 , C12N15/815 , C12P7/42 , Y02E50/10 , Y02P20/52
摘要： Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
摘要翻译： 本文提供重组酵母宿主细胞及其用于生产异丁醇的方法。 提供的酵母宿主细胞包含异丁醇生物合成途径和降低或消除的醛脱氢酶活性，降低或消除的乙酰乳酸还原酶活性中的至少一种; 或编码具有酮酸酸还原异构酶活性的多肽的异源多核苷酸。
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3.发明申请REDUCTION OF 2,3-DIHYDROXY-2-METHYL BUTYRATE (DHMB) IN BUTANOL PRODUCTION 审中-公开在丁醇生产中减少2,3-二羟基-2-甲基丁酸（DHMB）公开(公告)号：US20120258873A1
公开(公告)日：2012-10-11
申请号：US13153866
申请日：2011-06-06
申请人： KATHARINE J. GIBSON , Arthur Leo Kruckeberg , Lori Ann Maggio-Hall , Mark J. Nelson , Ranjan Patnaik
发明人： KATHARINE J. GIBSON , Arthur Leo Kruckeberg , Lori Ann Maggio-Hall , Mark J. Nelson , Ranjan Patnaik
CPC分类号： C12Q1/025 , C12N9/0006 , C12P7/16 , C12Q1/26 , Y02E50/10
摘要： The invention relates generally to the field of industrial microbiology and butanol production. More specifically, the invention relates methods of reducing 2,3-dihydroxy-2-methyl butyrate (DHMB) in butanol production. DHMB can be reduced by inhibiting the reduction of acetolactate to DHMB, for example, by knocking out enzymes that catalyze the reduction or by removing DHMB during or after fermentation. Yeast strains, compositions, and methods for reducing DHMB and increasing butanol yield are provided.
摘要翻译： 本发明一般涉及工业微生物学和丁醇生产领域。 更具体地，本发明涉及在丁醇生产中还原2,3-二羟基-2-甲基丁酸酯（DHMB）的方法。 通过抑制乙酰乳酸转化为DHMB可以减少DHMB，例如通过敲除催化还原的酶或在发酵过程中或之后除去DHMB。 提供了用于降低DHMB和提高丁醇产率的酵母菌株，组合物和方法。
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公开(公告)号：US20110312053A1
公开(公告)日：2011-12-22
申请号：US13162631
申请日：2011-06-17
CPC分类号： C12P7/16 , A23K10/38 , B01D3/002 , B01D11/0492 , B01D21/26 , B01D21/262 , C07C29/86 , C11B1/025 , C11B13/00 , C12F3/10 , C12M1/00 , C12M21/12 , C12M45/04 , C12M45/09 , C12N1/14 , C12N15/00 , C12P7/18 , C12P7/6418 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02W30/74
摘要： Fatty acids derived from biomass at a step in a fermentation process can be added to a fermentation medium comprising a recombinant microorganism that produces a product alcohol. At least one of growth rate and fermentable carbon consumption of the microorganism is greater in the presence of the fatty acids than the growth rate and the fermentable carbon consumption of the microorganism in the absence of the fatty acids. The addition of the fatty acids can increase glucose consumption, and can improve microorganism biomass production (cell growth/density) and growth rate, thereby reducing production time and increasing productivity of the fermentation process.
摘要翻译： 在发酵过程中的步骤中衍生自生物质的脂肪酸可以加入到包含产生产物醇的重组微生物的发酵培养基中。 在存在脂肪酸的情况下，微生物的生长速率和可发酵碳消耗量中的至少一种比在不存在脂肪酸时微生物的生长速率和可发酵碳消耗量更大。 脂肪酸的添加可以增加葡萄糖消耗，并且可以改善微生物生物量的生产（细胞生长/密度）和生长速率，从而减少生产时间并提高发酵过程的生产率。
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5.发明申请公开(公告)号：US20100144000A1
公开(公告)日：2010-06-10
申请号：US12328392
申请日：2008-12-04
IPC分类号： C12P7/06
CPC分类号： C12P7/06 , C07C29/86 , Y02E50/17 , Y02P20/542 , C07C31/08
摘要： This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
摘要翻译： 本发明涉及使用液 - 液萃取从发酵液中回收醇的方法，其中使用至少一种离子液体作为萃取溶剂。
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公开(公告)号：US20100143999A1
公开(公告)日：2010-06-10
申请号：US12328300
申请日：2008-12-04
IPC分类号： C12P7/06
CPC分类号： C12P7/06 , Y02E50/17 , Y02P20/542
摘要： This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
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公开(公告)号：US20100143995A1
公开(公告)日：2010-06-10
申请号：US12328336
申请日：2008-12-04
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , B01D11/0446 , Y02E50/10 , Y02E50/17 , Y02P20/542
摘要： This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
摘要翻译： 本发明涉及使用液 - 液萃取从发酵液中回收醇的方法，其中使用至少一种离子液体作为萃取溶剂。
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8.发明申请公开(公告)号：US20100143994A1
公开(公告)日：2010-06-10
申请号：US12328308
申请日：2008-12-04
IPC分类号： C12P7/16
CPC分类号： C12P7/06 , B01D11/0446 , C07C29/86 , C10G2300/1011 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y02P20/542 , Y02P30/20 , C07C31/12
摘要： This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
摘要翻译： 本发明涉及使用液 - 液萃取从发酵液中回收醇的方法，其中使用至少一种离子液体作为萃取溶剂。
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公开(公告)号：US07700328B2
公开(公告)日：2010-04-20
申请号：US11448331
申请日：2006-06-07
CPC分类号： C12P13/225
摘要： An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.
摘要翻译： 使用一步法将肠道细菌菌株设计为过度产生L-酪氨酸。 细菌基因组的pheA-tyrA染色体区被工程染色体片段替代，导致pheA编码区的失活和tyrA编码区的强表达，导致高水平的L-酪氨酸产生。
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公开(公告)号：US20090305370A1
公开(公告)日：2009-12-10
申请号：US12478389
申请日：2009-06-04
摘要： A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific organic extractants during fermentation
摘要翻译： 一种从至少一种可发酵碳源制造丁醇的方法，其克服了毒性问题，导致通过使用重组微生物宿主发酵的丁醇生产的有效滴度，有效速率和有效产率提高，其中提取丁醇 在发酵过程中变成特定的有机萃取剂
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