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    POLY(3-HYDROXYPROPIONATE-B-LACTATE) BLOCK COPOLYMER USING MICROORGANISMS
    2.
    发明申请
    POLY(3-HYDROXYPROPIONATE-B-LACTATE) BLOCK COPOLYMER USING MICROORGANISMS 有权

    公开(公告)号：US20220251612A1

    公开(公告)日：2022-08-11

    申请号：US17679007

    申请日：2022-02-23

    Applicant: LG CHEM, LTD.

    Inventor： Hye Ok KANG ,  Donggyun KANG ,  Chul Woong KIM ,  In Young HUH ,  Jung Yun CHOI

    IPC: C12P7/625 ,  C08G63/06 ,  C12N1/20 ,  C12N15/70 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C08G63/08 ,  C12N9/88

    Abstract: The present invention relates to a novel 3-hydroxypropionate-lactate block copolymer [P(3HP-b-LA)], and a method for preparing same, and more specifically, provides a method for preparing a 3-hydroxypropionate-lactate block copolymer, and a 3-hydroxypropionate-lactate block copolymer produced thereby, the method comprising: a first culture step in which, by using recombinant E. coli improved so as to be incapable of biosynthesizing lactic acid, P(3HP) is biosynthesized at the early stage of culturing by having glycerol as a carbon source and through 3-hydroxypropionate-generating genes and an enhanced PHA synthase; and a second culture step in which P(3HP) production is inhibited by using a carbon catabolic repression system for selectively introducing only glucose into E. coli when glycerol and glucose are supplied together as carbon sources, and in which polylactate is biosynthesized to an interrupted P(3HP) terminus by the enabling of the expression of a lactate synthase and a lactyl-CoA converting enzyme through an IPTG induction system.

    POLY(3-HYDROXYPROPIONATE-B-LACTATE) BLOCK COPOLYMER USING MICROORGANISMS
    7.
    发明申请
    POLY(3-HYDROXYPROPIONATE-B-LACTATE) BLOCK COPOLYMER USING MICROORGANISMS 审中-公开

    公开(公告)号：US20200270649A1

    公开(公告)日：2020-08-27

    申请号：US16754480

    申请日：2019-03-13

    Applicant: LG CHEM, LTD.

    Inventor： Hye Ok KANG ,  Donggyun KANG ,  Chul Woong KIM ,  In Young HUH ,  Jung Yun CHOI

    IPC: C12P7/62 ,  C12N1/20 ,  C12N15/70 ,  C08G63/06

    Abstract: Provided are a novel 3-hydroxypropionate-lactate block copolymer [P(3HP-b-LA)], and a method for preparing same, comprising: a) transforming a recombinant microorganism modified to be incapable of biosynthesizing lactic acid with a vector including a 3-hydroxypropionyl-CoA biosynthesis gene and a polyhydroxyalkanoate (PHA) synthetase gene, and a vector including a lactate biosynthesis gene and a gene of an enzyme that converts lactate to lactyl-CoA; (b) synthesizing poly(3-hydroxypropionate) (P(3HP)) by culturing the recombinant microorganism using a glycerol as a carbon source; and (c) inhibiting P(3HP) production by adding IPTG and glucose, and biosynthesizing polylactate (PLA) at the end of P(3HP) synthesized in step (b) by enabling the expression of a lactate biosynthesis enzyme and an enzyme that converts lactate to lactyl-CoA. Also provided is a recombinant microorganism produced in step a).

    BRANCHED POLY(3-HYDROXYPROPIONIC ACID)POLYMER, AND METHOD FOR PREPARATION THEREOF
    9.
    发明公开
    BRANCHED POLY(3-HYDROXYPROPIONIC ACID)POLYMER, AND METHOD FOR PREPARATION THEREOF 审中-公开

    公开(公告)号：US20240218115A1

    公开(公告)日：2024-07-04

    申请号：US18288849

    申请日：2022-05-06

    Applicant: LG CHEM, LTD.

    Inventor： Yeonju LEE ,  Jung Yun CHOI ,  Chul Woong KIM ,  Suhyun CHO ,  Kyeongmin KIM

    IPC: C08G63/06 ,  C08G63/85 ,  C08G63/87

    CPC classification number: C08G63/06 ,  C08G63/85 ,  C08G63/87

    Abstract: A novel branched poly(3-hydroxypropionic acid)polymer of Chemical Formula 1:


    R-[A-(B)n]k  [Chemical Formula 1]

    wherein: R is a trivalent or higher functional group derived from a polyfunctional monomer: A is a direct bond, or a linking group derived from ether, sulfide, ester, thioester, ketone, sulfoxide, sulfone, sulfonate ester, amine, amide, imine, imide, or urethane; B is a substituent of Chemical Formula 1-1 or Chemical Formula 1-2:




    * is a moiety connected to A; k is an integer of 3 or more: and n is an integer of 1 to 700, and a method for preparation thereof, which makes it possible to effectively prepare a polymer that achieves an excellent production yield while maintaining the intrinsic physical properties of poly(3-hydroxypropionic acid).

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