公开(公告)号：US20160178570A1

公开(公告)日：2016-06-23

申请号：US14971435

申请日：2015-12-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE

IPC: G01N27/414

CPC classification number: G01N27/4148 ,  G01N27/414

Abstract: A semiconductor device, comprising a first field effect transistor (FET) connected in series to a second FET, and a third FET connected in series to the first FET and the second FET. The semiconductor device further includes bias circuitry coupled to the first FET and the second FET, and an output conductor coupled to a terminal of the second FET, wherein the output conductor obtains an output signal from the second FET that is independent of the first FET.

Abstract translation: 一种半导体器件，包括与第二FET串联连接的第一场效应晶体管（FET）和与第一FET和第二FET串联连接的第三FET。 半导体器件还包括耦合到第一FET和第二FET的偏置电路以及耦合到第二FET的端子的输出导体，其中输出导体从第二FET获得独立于第一FET的输出信号。

公开(公告)号：US20160033449A1

公开(公告)日：2016-02-04

申请号：US14794595

申请日：2015-07-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE

IPC: G01N27/414

Abstract: The described embodiments may provide a chemical detection circuit. The chemical detection circuit may comprise a column of chemically-sensitive pixels. Each chemically-sensitive pixel may comprise a chemically-sensitive transistor, and a row selection device. The chemical detection circuit may further comprise a column interface circuit coupled to the column of chemically-sensitive pixels and an analog-to-digital converter (ADC) coupled to the column interface circuit. Each column interface circuit and column-level ADC may be arrayed with other identical circuits and share critical resources such as biasing and voltage references, thereby saving area and power.

Abstract translation: 所描述的实施例可以提供化学检测电路。 化学检测电路可以包括一列化学敏感像素。 每个化学敏感像素可以包括化学敏感晶体管和行选择器件。 化学检测电路还可以包括耦合到化学敏感像素列的列接口电路和耦合到列接口电路的模拟 - 数字转换器（ADC）。 每个列接口电路和列级ADC可以与其他相同的电路一起排列，并共享诸如偏置和电压参考的关键资源，从而节省面积和功率。

公开(公告)号：US20200278298A1

公开(公告)日：2020-09-03

申请号：US16830076

申请日：2020-03-25

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： William M. LAFFERTY ,  Jonathan M. ROTHBERG ,  Keith G. FIFE

IPC: G01N21/64 ,  C12Q1/6874

Abstract: A device including a transparent layer defining a surface exposed to a flow volume and to secure a target polynucleotide template and a detector structure secured to the transparent layer and including a plurality of detectors to detect a signal emitted during nucleotide incorporation along the target polynucleotide template.

公开(公告)号：US20160153930A1

公开(公告)日：2016-06-02

申请号：US15014802

申请日：2016-02-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE ,  Jordan OWENS ,  Shifeng LI ,  James BUSTILLO

IPC: G01N27/414

CPC classification number: G01N27/414 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0877 ,  G01N27/4145 ,  G01N27/4148

Abstract: In one implementation, a chemical device is described. The sensor includes a chemically-sensitive field effect transistor including a floating gate structure having a plurality of floating gate conductors electrically coupled to one another. A conductive element overlies and is in communication with an uppermost floating gate conductor in the plurality of floating gate conductors. The conductive element is wider and thinner than the uppermost floating gate conductor. A dielectric material defines an opening extending to an upper surface of the conductive element.

Abstract translation: 在一个实施方式中，描述了化学装置。 传感器包括化学敏感的场效应晶体管，其包括具有彼此电耦合的多个浮置栅极导体的浮动栅极结构。 导电元件覆盖并与多个浮置栅极导体中的最上面的浮动栅极导体连通。 导电元件比最上面的浮栅导体更宽和更薄。 介电材料限定了延伸到导电元件的上表面的开口。

公开(公告)号：US20140264472A1

公开(公告)日：2014-09-18

申请号：US14198417

申请日：2014-03-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE ,  Jordan OWENS ,  Shifeng LI ,  James BUSTILLO

IPC: G01N27/414

Abstract: In one embodiment, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A material defines an opening extending to the upper surface of the floating gate conductor, the material comprising a first dielectric underlying a second dielectric. A conductive element contacts the upper surface of the floating gate conductor and extending a distance along a sidewall of the opening.

Abstract translation: 在一个实施例中，描述了化学传感器。 化学传感器包括具有上表面的浮栅导体的化学敏感场效应晶体管。 材料限定了延伸到浮动栅极导体的上表面的开口，该材料包括位于第二电介质下面的第一电介质。 导电元件接触浮栅导体的上表面并沿着开口的侧壁延伸一段距离。

公开(公告)号：US20140264322A1

公开(公告)日：2014-09-18

申请号：US14197741

申请日：2014-03-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE ,  Jordan OWENS ,  Shifeng LI ,  James BUSTILLO

IPC: G01N27/414

CPC classification number: G01N27/4145

Abstract: In one implementation, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A conductive element protrudes from the upper surface of the floating gate conductor into an opening. A dielectric material defines a reaction region. The reaction region overlies and extends below an upper surface of the conductive element.

Abstract translation: 在一个实施方式中，描述了化学传感器。 化学传感器包括具有上表面的浮栅导体的化学敏感场效应晶体管。 导电元件从浮栅导体的上表面突出到开口中。 电介质材料限定了反应区域。 反应区域覆盖并延伸到导电元件的上表面下方。

公开(公告)号：US20130228829A1

公开(公告)日：2013-09-05

申请号：US13849343

申请日：2013-03-22

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE ,  Kim L. JOHNSON ,  Mark James MILGREW

IPC: H01L29/66

CPC classification number: G01N27/4148 ,  C12Q1/6869 ,  G01J1/46 ,  G01N27/4143 ,  G01N27/4145 ,  G01N33/00 ,  G01R29/26 ,  H01L27/14609 ,  H01L27/14632 ,  H01L27/14643 ,  H01L29/66 ,  H01L2924/0002 ,  H04N5/374 ,  Y10T436/25875 ,  H01L2924/00

Abstract: A two-transistor (2T) pixel comprises a chemically-sensitive transistor (ChemFET) and a selection device which is a non-chemically sensitive transistor. A plurality of the 2T pixels may form an array, having a number of rows and a number of columns. The ChemFET can be configured in a source follower or common source readout mode. Both the ChemFET and the non-chemically sensitive transistor can be NMOS or PMOS device.

Abstract translation: 双晶体管（2T）像素包括化学敏感晶体管（ChemFET）和作为非化学敏感晶体管的选择器件。 多个2T像素可以形成具有多行和多列的阵列。 ChemFET可以配置为源跟踪器或公共源读出模式。 ChemFET和非化学敏感晶体管都可以是NMOS或PMOS器件。

公开(公告)号：US20160177385A1

公开(公告)日：2016-06-23

申请号：US14965568

申请日：2015-12-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE ,  Jungwook YANG

IPC: C12Q1/68 ,  G01N35/00 ,  G01N27/414

CPC classification number: C12Q1/6874 ,  G01N27/4145 ,  G01N27/4148 ,  G01N35/00712 ,  G01N35/00871 ,  G01N2035/00881

Abstract: A sensor device includes a sensor array and a flow cell in fluid communication with the sensor array. Bias circuitry apply bias arrangements to the sensor array to produce sensor data. Peripheral circuitry coupled to the bias circuitry produces streams of data from the sensor array, the peripheral circuitry having an active mode and an idle mode. Logic to switch the peripheral circuitry between the active mode and the idle mode to control power consumption is provided. A temperature sensor may be included, and the logic can operate with feedback to switch between the active mode and the idle mode to maintain the temperature within an operating range.

Abstract translation: 传感器装置包括传感器阵列和与传感器阵列流体连通的流动池。 偏置电路将偏置布置应用于传感器阵列以产生传感器数据。 耦合到偏置电路的外围电路产生来自传感器阵列的数据流，外围电路具有活动模式和空闲模式。 提供了在活动模式和空闲模式之间切换外围电路以控制功耗的逻辑。 可以包括温度传感器，并且逻辑可以通过反馈来操作，以在活动模式和空闲模式之间切换，以将温度保持在工作范围内。

公开(公告)号：US20140364320A1

公开(公告)日：2014-12-11

申请号：US14293247

申请日：2014-06-02

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jonathan M. ROTHBERG ,  Keith G. FIFE ,  James BUSTILLO ,  James OWENS

IPC: G01N27/414 ,  H01L29/66 ,  C12Q1/68

CPC classification number: G01N27/4145 ,  C12Q1/6874 ,  G01N27/414 ,  H01L29/66825

Abstract: In one embodiment, a device is described. The device includes a material defining a reaction region. The device also includes a plurality of chemically-sensitive field effect transistors have a common floating gate in communication with the reaction region. The device also includes a circuit to obtain respective output signals from the chemically-sensitive field effect transistors indicating an analyte within the reaction region.

Abstract translation: 在一个实施例中，描述了一种装置。 该装置包括限定反应区域的材料。 该器件还包括多个化学敏感的场效应晶体管，其具有与反应区域连通的公共浮动栅极。 该装置还包括电路，以从化学敏感的场效应晶体管获得指示反应区域内的分析物的相应输出信号。

公开(公告)号：US20140264470A1

公开(公告)日：2014-09-18

申请号：US14198382

申请日：2014-03-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Keith G. FIFE ,  Jordan OWENS ,  Shifeng LI ,  James BUSTILLO

IPC: G01N27/414

CPC classification number: G01N27/414 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0877 ,  G01N27/4145 ,  G01N27/4148

Abstract: In one embodiment, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A material defines an opening extending to the upper surface of the floating gate conductor. The material comprises a first dielectric underlying a second dielectric. A conductive element contacts the upper surface of the floating gate conductor and extends a distance along a sidewall of the opening, the distance defined by a thickness of the first dielectric.

Abstract translation: 在一个实施例中，描述了化学传感器。 化学传感器包括具有上表面的浮栅导体的化学敏感场效应晶体管。 材料限定了延伸到浮动栅极导体的上表面的开口。 该材料包括位于第二电介质下面的第一电介质。 导电元件接触浮动栅极导体的上表面并且沿着开口的侧壁延伸一定距离，该距离由第一电介质的厚度限定。