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公开(公告)号：US20190194532A1
公开(公告)日：2019-06-27
申请号：US16324730
申请日：2017-08-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Adam YORK , Eric WELCH , Kyle GEE , Xin WANG , Robert AGGELER , Yi-Zhen HU
CPC classification number: C09K11/025 , C09B68/41 , C09K11/06 , C09K2211/1416 , C09K2211/1483 , G01N33/5005 , G01N33/533 , G01N33/582 , H04L12/1822 , H04L12/1827 , H04L12/1895 , H04L67/10
Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
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公开(公告)号：US20220119701A1
公开(公告)日：2022-04-21
申请号：US17514492
申请日：2021-10-29
Applicant: Life Technologies Corporation
Inventor： Adam YORK , Eric WELCH , Kyle GEE , Xin WANG , Robert AGGELER , Yi-Zhen HU
Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
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3.发明申请公开(公告)号：US20200179541A1
公开(公告)日：2020-06-11
申请号：US16713388
申请日：2019-12-13
Applicant: Life Technologies Corporation
Inventor： Brian AGNEW , Robert AGGELER , Hee Chol KANG , Aimei CHEN , Kyle GEE
IPC: A61K51/10 , G01N33/534 , G01N33/68 , C07K14/435 , C07K16/18 , C12P21/00 , C12P21/06 , G01N33/58
Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
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公开(公告)号：US20200330610A1
公开(公告)日：2020-10-22
申请号：US16882271
申请日：2020-05-22
Applicant: Life Technologies Corporation , Pierce Biotechnology, Inc.
Inventor： Surbhi DESAI , Marie Christine NLEND , Kyle GEE , Matthew BAKER , Robert AGGELER , Scott SWEENEY , Aleksey RUKAVISHNIKOV , Shih-Jung HUANG
Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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Patent Agency Ranking
公开(公告)号：US20180092993A1
公开(公告)日：2018-04-05
申请号：US15693772
申请日：2017-09-01
Applicant: Life Technologies Corporation , Pierce Biotechnology, Inc.
Inventor： Surbhi DESAI , Marie Christine NLEND , Kyle GEE , Matthew BAKER , Robert AGGELER , Scott SWEENEY , Aleksey RUKAVISHNIKOV , Shih-Jung HUANG
IPC: A61K49/00 , A61K47/18 , A61K47/10 , G01N33/533 , G01N33/68
CPC classification number: A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US20200261602A1
公开(公告)日：2020-08-20
申请号：US16816015
申请日：2020-03-11
Applicant: Life Technologies Corporation , Pierce Biotechnology, Inc.
Inventor： Surbhi DESAI , Marie Christine NLEND , Kyle GEE , Matthew BAKER , Robert AGGELER , Scott SWEENEY , Aleksey RUKAVISHNIKOV , Shih-Jung HUANG
Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US20190177438A1
公开(公告)日：2019-06-13
申请号：US16306610
申请日：2017-06-16
Applicant: Life Technologies Corporation
Inventor： Brian AGNEW , Robert AGGELER , Rolando BRAWER
Abstract: Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.
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8.发明申请公开(公告)号：US20180078662A1
公开(公告)日：2018-03-22
申请号：US15826593
申请日：2017-11-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Brian AGNEW , Robert AGGELER , Hee Chol KANG , Aimei CHEN , Kyle GEE
IPC: A61K51/10 , G01N33/534 , C12P21/00 , C07K16/18 , G01N33/68 , C12P21/06 , C07K14/435 , G01N33/58
CPC classification number: A61K51/10 , C07K14/435 , C07K16/18 , C12P21/005 , C12P21/06 , G01N33/534 , G01N33/582 , G01N33/6854
Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
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公开(公告)号：US20170247504A1
公开(公告)日：2017-08-31
申请号：US15491650
申请日：2015-08-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle GEE , Xin WANG , Hee Chol KANG , Aimei CHEN , Yexin WU , Yi-Zhen HU , Robert AGGELER , Quentin LOW
IPC: C08G61/12 , G01N33/545 , G01N33/58 , G01N33/533 , C07F7/08 , C09K11/06
CPC classification number: C08G61/123 , C07F7/0816 , C07F7/083 , C08G2261/122 , C08G2261/124 , C08G2261/1424 , C08G2261/145 , C08G2261/1644 , C08G2261/1646 , C08G2261/3142 , C08G2261/3244 , C08G2261/334 , C08G2261/344 , C08G2261/411 , C08G2261/522 , C08G2261/5222 , C08G2261/72 , C08G2261/94 , C08L65/00 , C09K11/06 , C09K2211/1416 , C09K2211/1491 , G01N33/533 , G01N33/545 , G01N33/582 , H01L51/0039 , H01L51/0043 , H01L51/0094
Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
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