公开(公告)号：US20240228785A1

公开(公告)日：2024-07-11

申请号：US18419897

申请日：2024-01-23

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yi-Zhen HU ,  Aimei CHEN ,  Daniel BEACHAM ,  Chrisgen VONNEGUT ,  Krishnamurthy NACHARAJU

IPC: C09B11/24 ,  G01N21/64

CPC classification number: C09B11/24 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The present disclosure provides for compounds of Formula (I),




its corresponding compounds of Formula (II)




or salts thereof and their use as fluorogenic pH sensors.

公开(公告)号：US20200179541A1

公开(公告)日：2020-06-11

申请号：US16713388

申请日：2019-12-13

Applicant: Life Technologies Corporation

Inventor： Brian AGNEW ,  Robert AGGELER ,  Hee Chol KANG ,  Aimei CHEN ,  Kyle GEE

IPC: A61K51/10 ,  G01N33/534 ,  G01N33/68 ,  C07K14/435 ,  C07K16/18 ,  C12P21/00 ,  C12P21/06 ,  G01N33/58

Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.

公开(公告)号：US20160031821A1

公开(公告)日：2016-02-04

申请号：US14810766

申请日：2015-07-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle GEE ,  Aimei CHEN ,  Hee Chol KANG

IPC: C07D225/08 ,  C07D225/02 ,  C07C309/42

CPC classification number: C07D225/08 ,  C07C309/42 ,  C07C2603/36 ,  C07D223/08 ,  C07D223/26 ,  C07D225/02 ,  C07K1/13 ,  C07K16/18 ,  G01N33/532

Abstract: The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application.

Abstract translation: 本公开涉及用于将点击反应性基团与载体分子或固体支持物缀合的反应性酯试剂。 反应性酯剂具有通式IA，其中在整个申请中描述了变量R1，R2，R3，Ra和L。

公开(公告)号：US20210324198A1

公开(公告)日：2021-10-21

申请号：US17150247

申请日：2019-08-08

Applicant: Life Technologies Corporation

Inventor： Jongtae YANG ,  Xin WANG ,  Yi-Zhen HU ,  Kyle GEE ,  Aimei CHEN ,  Scott BENSON ,  Brian EVANS ,  Aleksey RUKAVISHNIKOV

IPC: C09B11/28 ,  C07F7/08 ,  C07F9/6561 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N33/58

Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.

公开(公告)号：US20160356782A1

公开(公告)日：2016-12-08

申请号：US15176872

申请日：2016-06-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Aimei CHEN ,  Kyle Gee ,  Hee Chol Kang

IPC: G01N33/64 ,  C09K11/06 ,  G01N21/64 ,  C09B11/24 ,  G01N33/50

CPC classification number: G01N33/64 ,  C07D311/82 ,  C07D471/06 ,  C07F5/022 ,  C07F9/5442 ,  C07F9/65522 ,  C09B11/24 ,  C09K11/06 ,  C09K2211/10 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1022 ,  C09K2211/1033 ,  C09K2211/1055 ,  C09K2211/1088 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/50 ,  G01N33/52 ,  G01N2021/6439 ,  Y10T436/143333

Abstract: The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ.

公开(公告)号：US20180078662A1

公开(公告)日：2018-03-22

申请号：US15826593

申请日：2017-11-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Brian AGNEW ,  Robert AGGELER ,  Hee Chol KANG ,  Aimei CHEN ,  Kyle GEE

IPC: A61K51/10 ,  G01N33/534 ,  C12P21/00 ,  C07K16/18 ,  G01N33/68 ,  C12P21/06 ,  C07K14/435 ,  G01N33/58

CPC classification number: A61K51/10 ,  C07K14/435 ,  C07K16/18 ,  C12P21/005 ,  C12P21/06 ,  G01N33/534 ,  G01N33/582 ,  G01N33/6854

Abstract: Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.

公开(公告)号：US20170247504A1

公开(公告)日：2017-08-31

申请号：US15491650

申请日：2015-08-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle GEE ,  Xin WANG ,  Hee Chol KANG ,  Aimei CHEN ,  Yexin WU ,  Yi-Zhen HU ,  Robert AGGELER ,  Quentin LOW

IPC: C08G61/12 ,  G01N33/545 ,  G01N33/58 ,  G01N33/533 ,  C07F7/08 ,  C09K11/06

CPC classification number: C08G61/123 ,  C07F7/0816 ,  C07F7/083 ,  C08G2261/122 ,  C08G2261/124 ,  C08G2261/1424 ,  C08G2261/145 ,  C08G2261/1644 ,  C08G2261/1646 ,  C08G2261/3142 ,  C08G2261/3244 ,  C08G2261/334 ,  C08G2261/344 ,  C08G2261/411 ,  C08G2261/522 ,  C08G2261/5222 ,  C08G2261/72 ,  C08G2261/94 ,  C08L65/00 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1491 ,  G01N33/533 ,  G01N33/545 ,  G01N33/582 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/0094

Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.