公开(公告)号：US20220119701A1

公开(公告)日：2022-04-21

申请号：US17514492

申请日：2021-10-29

Applicant: Life Technologies Corporation

Inventor： Adam YORK ,  Eric WELCH ,  Kyle GEE ,  Xin WANG ,  Robert AGGELER ,  Yi-Zhen HU

IPC: C09K11/02 ,  C09B67/00 ,  C09K11/06 ,  G01N33/50 ,  G01N33/533 ,  G01N33/58 ,  H04L12/18

Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

公开(公告)号：US20250084250A1

公开(公告)日：2025-03-13

申请号：US18580315

申请日：2022-07-20

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yi-Zhen HU ,  Brian EVANS

IPC: C09B23/08 ,  G01N33/533

Abstract: The present disclosure relates to new and useful azaindole cyanine (pyrrolo pyridine cyanine) compounds. Use of the compounds as dyes that operate in the far-red and near-IR spectral region in biological imaging, and methods of making the compounds are also disclosed herein. The azaindole cyanine (pyrrolo pyridine cyanine) compounds have formulas (I) and (II).

公开(公告)号：US20190194532A1

公开(公告)日：2019-06-27

申请号：US16324730

申请日：2017-08-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Adam YORK ,  Eric WELCH ,  Kyle GEE ,  Xin WANG ,  Robert AGGELER ,  Yi-Zhen HU

IPC: C09K11/02 ,  C09K11/06 ,  C09B67/00 ,  G01N33/50 ,  G01N33/533 ,  G01N33/58

CPC classification number: C09K11/025 ,  C09B68/41 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1483 ,  G01N33/5005 ,  G01N33/533 ,  G01N33/582 ,  H04L12/1822 ,  H04L12/1827 ,  H04L12/1895 ,  H04L67/10

Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

公开(公告)号：US20240182451A1

公开(公告)日：2024-06-06

申请号：US18415904

申请日：2024-01-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yi-Zhen HU ,  Brian EVANS

IPC: C07D403/06 ,  C07D471/04 ,  C07D519/00 ,  C09B23/04 ,  C09B23/08 ,  G01N21/64 ,  G01N33/533

CPC classification number: C07D403/06 ,  C07D471/04 ,  C07D519/00 ,  C09B23/04 ,  C09B23/083 ,  G01N21/64 ,  G01N33/533

Abstract: The present disclosure relates to new and useful azaindole cyanine (pyrrolo pyridine cyanine) compounds. Use of the compounds as dyes that operate in the far-red and near-IR spectral region in biological imaging, and methods of making and using the compounds are also disclosed herein.

公开(公告)号：US20170247504A1

公开(公告)日：2017-08-31

申请号：US15491650

申请日：2015-08-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle GEE ,  Xin WANG ,  Hee Chol KANG ,  Aimei CHEN ,  Yexin WU ,  Yi-Zhen HU ,  Robert AGGELER ,  Quentin LOW

IPC: C08G61/12 ,  G01N33/545 ,  G01N33/58 ,  G01N33/533 ,  C07F7/08 ,  C09K11/06

CPC classification number: C08G61/123 ,  C07F7/0816 ,  C07F7/083 ,  C08G2261/122 ,  C08G2261/124 ,  C08G2261/1424 ,  C08G2261/145 ,  C08G2261/1644 ,  C08G2261/1646 ,  C08G2261/3142 ,  C08G2261/3244 ,  C08G2261/334 ,  C08G2261/344 ,  C08G2261/411 ,  C08G2261/522 ,  C08G2261/5222 ,  C08G2261/72 ,  C08G2261/94 ,  C08L65/00 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1491 ,  G01N33/533 ,  G01N33/545 ,  G01N33/582 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/0094

Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

公开(公告)号：US20240228785A1

公开(公告)日：2024-07-11

申请号：US18419897

申请日：2024-01-23

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yi-Zhen HU ,  Aimei CHEN ,  Daniel BEACHAM ,  Chrisgen VONNEGUT ,  Krishnamurthy NACHARAJU

IPC: C09B11/24 ,  G01N21/64

CPC classification number: C09B11/24 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The present disclosure provides for compounds of Formula (I),




its corresponding compounds of Formula (II)




or salts thereof and their use as fluorogenic pH sensors.

公开(公告)号：US20230085832A1

公开(公告)日：2023-03-23

申请号：US17936947

申请日：2022-09-30

Applicant: Life Technologies Corporation

Inventor： Kyle GEE ,  Kathleen KIHN ,  Yi-Zhen HU ,  Yexin WU ,  Kathleen FREE

IPC: G01N21/64 ,  C07D311/82 ,  C07D209/10 ,  C07F15/00 ,  C07F9/24

Abstract: Provided herein are compounds, compositions, kits, uses, and methods for assessing the viability of cells and/or quantifying the amount of live and dead cells in a mixture using differential stains. In some embodiments, the compounds are used in culture media or can function independently of fixation and/or permeabilization. In some embodiments, the compounds comprise a platinum atom. In some embodiments, the compounds comprise a nitrogen mustard moiety.

公开(公告)号：US20150090936A1

公开(公告)日：2015-04-02

申请号：US14566166

申请日：2014-12-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yi-Zhen HU ,  Hee Chol KANG

IPC: C09K11/06 ,  C07D209/26 ,  C07H19/207 ,  C07D401/10

CPC classification number: C07H19/207 ,  C07D209/14 ,  C07D209/26 ,  C07D401/10 ,  C07D401/14 ,  C09B23/0041 ,  C09B23/0066 ,  C09B23/086 ,  C09B23/164 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1022 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1074 ,  G01N33/52

Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.

Abstract translation: 本文提供具有大的斯托克斯位移的七甲基氰花青染料及其盐和共轭物。 还提供了使用和制备这种大的斯托克斯位移染料作为荧光共振能量转移（FRET）受体或供体的方法。

公开(公告)号：US20210324198A1

公开(公告)日：2021-10-21

申请号：US17150247

申请日：2019-08-08

Applicant: Life Technologies Corporation

Inventor： Jongtae YANG ,  Xin WANG ,  Yi-Zhen HU ,  Kyle GEE ,  Aimei CHEN ,  Scott BENSON ,  Brian EVANS ,  Aleksey RUKAVISHNIKOV

IPC: C09B11/28 ,  C07F7/08 ,  C07F9/6561 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N33/58

Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.

公开(公告)号：US20170166603A1

公开(公告)日：2017-06-15

申请号：US15438006

申请日：2017-02-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yi-Zhen HU ,  Hee Chol KANG

IPC: C07H19/207 ,  C09K11/06 ,  C07D209/14 ,  C09B23/16 ,  C07D401/14

CPC classification number: C07H19/207 ,  C07D209/14 ,  C07D209/26 ,  C07D401/10 ,  C07D401/14 ,  C09B23/0041 ,  C09B23/0066 ,  C09B23/086 ,  C09B23/164 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1022 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1074 ,  G01N33/52

Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.