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公开(公告)号:US20190194532A1
公开(公告)日:2019-06-27
申请号:US16324730
申请日:2017-08-24
发明人: Adam YORK , Eric WELCH , Kyle GEE , Xin WANG , Robert AGGELER , Yi-Zhen HU
CPC分类号: C09K11/025 , C09B68/41 , C09K11/06 , C09K2211/1416 , C09K2211/1483 , G01N33/5005 , G01N33/533 , G01N33/582 , H04L12/1822 , H04L12/1827 , H04L12/1895 , H04L67/10
摘要: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
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公开(公告)号:US20220119701A1
公开(公告)日:2022-04-21
申请号:US17514492
申请日:2021-10-29
发明人: Adam YORK , Eric WELCH , Kyle GEE , Xin WANG , Robert AGGELER , Yi-Zhen HU
摘要: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
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公开(公告)号:US20170247504A1
公开(公告)日:2017-08-31
申请号:US15491650
申请日:2015-08-14
发明人: Kyle GEE , Xin WANG , Hee Chol KANG , Aimei CHEN , Yexin WU , Yi-Zhen HU , Robert AGGELER , Quentin LOW
IPC分类号: C08G61/12 , G01N33/545 , G01N33/58 , G01N33/533 , C07F7/08 , C09K11/06
CPC分类号: C08G61/123 , C07F7/0816 , C07F7/083 , C08G2261/122 , C08G2261/124 , C08G2261/1424 , C08G2261/145 , C08G2261/1644 , C08G2261/1646 , C08G2261/3142 , C08G2261/3244 , C08G2261/334 , C08G2261/344 , C08G2261/411 , C08G2261/522 , C08G2261/5222 , C08G2261/72 , C08G2261/94 , C08L65/00 , C09K11/06 , C09K2211/1416 , C09K2211/1491 , G01N33/533 , G01N33/545 , G01N33/582 , H01L51/0039 , H01L51/0043 , H01L51/0094
摘要: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
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公开(公告)号:US20230085832A1
公开(公告)日:2023-03-23
申请号:US17936947
申请日:2022-09-30
发明人: Kyle GEE , Kathleen KIHN , Yi-Zhen HU , Yexin WU , Kathleen FREE
IPC分类号: G01N21/64 , C07D311/82 , C07D209/10 , C07F15/00 , C07F9/24
摘要: Provided herein are compounds, compositions, kits, uses, and methods for assessing the viability of cells and/or quantifying the amount of live and dead cells in a mixture using differential stains. In some embodiments, the compounds are used in culture media or can function independently of fixation and/or permeabilization. In some embodiments, the compounds comprise a platinum atom. In some embodiments, the compounds comprise a nitrogen mustard moiety.
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公开(公告)号:US20150090936A1
公开(公告)日:2015-04-02
申请号:US14566166
申请日:2014-12-10
发明人: Yi-Zhen HU , Hee Chol KANG
IPC分类号: C09K11/06 , C07D209/26 , C07H19/207 , C07D401/10
CPC分类号: C07H19/207 , C07D209/14 , C07D209/26 , C07D401/10 , C07D401/14 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B23/164 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1044 , C09K2211/1059 , C09K2211/1074 , G01N33/52
摘要: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
摘要翻译: 本文提供具有大的斯托克斯位移的七甲基氰花青染料及其盐和共轭物。 还提供了使用和制备这种大的斯托克斯位移染料作为荧光共振能量转移(FRET)受体或供体的方法。
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公开(公告)号:US20210324198A1
公开(公告)日:2021-10-21
申请号:US17150247
申请日:2019-08-08
发明人: Jongtae YANG , Xin WANG , Yi-Zhen HU , Kyle GEE , Aimei CHEN , Scott BENSON , Brian EVANS , Aleksey RUKAVISHNIKOV
IPC分类号: C09B11/28 , C07F7/08 , C07F9/6561 , C12Q1/6816 , C12Q1/6869 , G01N33/58
摘要: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.
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公开(公告)号:US20170166603A1
公开(公告)日:2017-06-15
申请号:US15438006
申请日:2017-02-21
发明人: Yi-Zhen HU , Hee Chol KANG
IPC分类号: C07H19/207 , C09K11/06 , C07D209/14 , C09B23/16 , C07D401/14
CPC分类号: C07H19/207 , C07D209/14 , C07D209/26 , C07D401/10 , C07D401/14 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B23/164 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1044 , C09K2211/1059 , C09K2211/1074 , G01N33/52
摘要: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
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8.
公开(公告)号:US20170108518A1
公开(公告)日:2017-04-20
申请号:US15340134
申请日:2016-11-01
发明人: Yi-Zhen HU , Aimei Chen , Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli
摘要: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
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