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公开(公告)号：US20110189669A1
公开(公告)日：2011-08-04
申请号：US13000079
申请日：2009-06-19
申请人： Laki Buluwela , Jonathan Waxman , Simak Ali , Sarah Ngan
发明人： Laki Buluwela , Jonathan Waxman , Simak Ali , Sarah Ngan
CPC分类号： G01N33/57434 , A61K31/00 , A61K31/167 , A61K31/519 , A61K31/7076 , A61K31/7088 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N2333/91017 , A61K2300/00
摘要： The current invention provides a method for aiding in the assessment of prostate cancer (including metastatic prostate cancer) and/or benign prostate hyperplasia in a patient, wherein the method comprises the step of determining the level of Glycine N-methyltransferase (GNMT) nucleic acid and/or protein in a sample from the patient. The invention also provides compounds that target Glycine N-methyltransferase (GNMT) protein and/or nucleic acid for use in treating prostate cancer. Also provided are screening methods for selecting a compound considered to be useful in treating prostate cancer, comprising the steps of determining the ability of a test compound to reduce GNMT activity and selecting a compound that reduces GNMT activity. The invention also provides methods for aiding in the diagnosis of prostate cancer in a patient comprising obtaining a sample from the patient and assessing said sample for a marker of GNMT activity.
摘要翻译： 本发明提供了一种帮助评估患者前列腺癌（包括转移性前列腺癌）和/或良性前列腺增生的方法，其中该方法包括确定甘氨酸N-甲基转移酶（GNMT）核酸水平的步骤 和/或来自患者的样品中的蛋白质。 本发明还提供靶向用于治疗前列腺癌的甘氨酸N-甲基转移酶（GNMT）蛋白和/或核酸的化合物。 还提供了用于选择被认为可用于治疗前列腺癌的化合物的筛选方法，包括确定测试化合物降低GNMT活性并选择降低GNMT活性的化合物的能力的步骤。 本发明还提供了帮助诊断患者中前列腺癌的方法，包括从患者获得样品并评估所述样品以获得GNMT活性标志物。
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2.发明申请Control of gene expression using a complex of an oligonucleotide and a regulatory peptide 审中-公开使用寡核苷酸和调节肽的复合物控制基因表达公开(公告)号：US20090082250A1
公开(公告)日：2009-03-26
申请号：US12152175
申请日：2008-05-13
申请人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C. G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C. G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译： 一种抑制细胞中所选择的基因表达的方法，包括向细胞中引入分子，所述分子包含（1）核酸结合部分，所述核酸结合部分结合位点或与所选基因相关联，所述基因存在于基因组中， （2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。 提供了用于本发明方法的分子。 阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。
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3.发明申请Control of Gene Expression Using a Complex of an Oligonucleotide and a Regulatory Peptide 审中-公开使用寡核苷酸和调节肽的复合物控制基因表达公开(公告)号：US20120077270A1
公开(公告)日：2012-03-29
申请号：US13251627
申请日：2011-10-03
申请人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译： 一种用于抑制细胞中所选基因表达的方法，所述方法包括向细胞中引入包含（1）结合位点或与选定基因相关的核酸结合部分的分子，该位点存在于基因组中 和（2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。 提供了用于本发明方法的分子。 阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。
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4.发明申请Control of gene expression using a complex of an oligonucleotide and a regulatory peptide 审中-公开使用寡核苷酸和调节肽的复合物控制基因表达公开(公告)号：US20050136040A1
公开(公告)日：2005-06-23
申请号：US10824584
申请日：2004-04-08
申请人： Stephen Hart , Simak Ali , Boris PuFong , Andrew Porter , Laki Buluwela , Satu Vainikka , John Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris PuFong , Andrew Porter , Laki Buluwela , Satu Vainikka , John Jenkinson , Patrick Kanda
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译： 一种抑制细胞中所选择的基因表达的方法，包括向细胞中引入分子，所述分子包含（1）核酸结合部分，所述核酸结合部分结合位点或与所选基因相关联，所述基因存在于基因组中， （2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。 提供了用于本发明方法的分子。 阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。
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公开(公告)号：US20100261683A1
公开(公告)日：2010-10-14
申请号：US12631373
申请日：2009-12-04
申请人： Ashutosh S. Jogalekar , James P. Snyder , Dennis C. Liotta , Anthony G.M. Barrett , RCDS Coombes , Simak Ali , Aleksandra Siwicka , Jan Brackow , Bodo Scheiper
发明人： Ashutosh S. Jogalekar , James P. Snyder , Dennis C. Liotta , Anthony G.M. Barrett , RCDS Coombes , Simak Ali , Aleksandra Siwicka , Jan Brackow , Bodo Scheiper
IPC分类号： A61K31/635 , C07D487/04 , A61K31/519 , A61P35/00 , C12N9/12
CPC分类号： A61K31/519 , C07D487/04
摘要： This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.
摘要翻译： 本发明提供一类可用于特异性抑制细胞周期蛋白依赖性激酶的化合物。 这类化合物可用于治疗由细胞周期蛋白依赖性激酶（包括癌症，病毒感染（例如HIV））神经变性疾病（例如阿尔茨海默病）和心血管疾病（例如动脉粥样硬化）的不适当活动引起的疾病。 此外，该类的某些成员特别可用于抑制细胞周期蛋白依赖性激酶7，并且特别可用于治疗乳腺癌。
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公开(公告)号：US20080026985A1
公开(公告)日：2008-01-31
申请号：US11712311
申请日：2007-02-28
申请人： Lakjaya Buluwela , Simak Ali
发明人： Lakjaya Buluwela , Simak Ali
IPC分类号： A61K31/7088 , A61K38/00 , A61P43/00 , C12N1/00 , C12N1/21 , C12N15/09 , C12N5/04 , C12N5/06 , C12N5/10
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00
摘要： A method of suppressing the expression of a selected gene in a eukaryotic cell the method comprising introducing into the cell (a) a polypeptide comprising a DNA binding portion which binds to a site at or associated with the selected gene which site is present in a plant or animal genome and a chromatin inactivation portion, or (b) a polynucleotide encoding said polypeptide.
摘要翻译： 一种抑制真核细胞中所选择的基因表达的方法，该方法包括向细胞（a）中引入多肽，所述多肽包含与所选择的基因存在于植物中的位点结合的位点或与其结合的DNA结合部分 或动物基因组和染色质失活部分，或（b）编码所述多肽的多核苷酸。
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公开(公告)号：US08067424B2
公开(公告)日：2011-11-29
申请号：US12631373
申请日：2009-12-04
申请人： Ashutosh S. Jogalekar , James P. Snyder , Dennis C. Liotta , Anthony G. M. Barrett , Raoul Charles Dalmedo Stuart Coombes , Simak Ali , Aleksandra Siwicka , Jan Brackow , Bodo Scheiper
发明人： Ashutosh S. Jogalekar , James P. Snyder , Dennis C. Liotta , Anthony G. M. Barrett , Raoul Charles Dalmedo Stuart Coombes , Simak Ali , Aleksandra Siwicka , Jan Brackow , Bodo Scheiper
IPC分类号： C07D487/00 , A01N43/90 , C12N9/12
CPC分类号： A61K31/519 , C07D487/04
摘要： This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.
摘要翻译： 本发明提供一类可用于特异性抑制细胞周期蛋白依赖性激酶的化合物。 这类化合物可用于治疗由细胞周期蛋白依赖性激酶（包括癌症，病毒感染（例如HIV））神经变性疾病（例如阿尔茨海默病）和心血管疾病（例如动脉粥样硬化）的不适当活动引起的疾病。 此外，该类的某些成员特别可用于抑制细胞周期蛋白依赖性激酶7，并且特别可用于治疗乳腺癌。
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公开(公告)号：US07202025B1
公开(公告)日：2007-04-10
申请号：US10019520
申请日：2000-06-28
申请人： Lakjaya Buluwela , Simak Ali
发明人： Lakjaya Buluwela , Simak Ali
IPC分类号： C12Q1/68 , C12N15/63 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00
摘要： A method of suppressing the expression of a selected gene in a eukaryotic cell the method comprising introducing into the cell (a) a polypeptide comprising a DNA binding portion which binds to a site at or associated with the selected gene which site is present in a plant r animal genome and a chromatin inactivation portion, or (b) a polynucleotide encoding said polypeptide.
摘要翻译： 一种抑制真核细胞中所选择的基因表达的方法，该方法包括向细胞（a）中引入多肽，所述多肽包含与所选择的基因存在于植物中的位点结合的位点或与其结合的DNA结合部分 r动物基因组和染色质失活部分，或（b）编码所述多肽的多核苷酸。
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