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1.发明申请Polypeptides Having Phospholipase C Activity and Polynucleotides Encoding Same 有权具有磷脂酶C活性的多肽和编码相同的多核苷酸公开(公告)号：US20130309751A1
公开(公告)日：2013-11-21
申请号：US13884063
申请日：2011-11-09
申请人： Lan Tang , Ye Liu , Kim Borch , Jesper Brask
发明人： Lan Tang , Ye Liu , Kim Borch , Jesper Brask
CPC分类号： A23D9/04 , C11B3/003 , C12N9/16 , C12N9/20 , C12Y301/04003
摘要： The present invention relates to isolated polypeptides having phospholipase C activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译： 本发明涉及具有磷脂酶C活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。
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公开(公告)号：US09279110B2
公开(公告)日：2016-03-08
申请号：US13884063
申请日：2011-11-09
申请人： Lan Tang , Ye Liu , Kim Borch , Jesper Brask
发明人： Lan Tang , Ye Liu , Kim Borch , Jesper Brask
IPC分类号： C07H21/04 , C12N15/00 , C12N1/14 , C12N1/20 , C12N5/04 , C12N5/07 , C12P21/02 , C12N9/20 , C11B3/00
CPC分类号： A23D9/04 , C11B3/003 , C12N9/16 , C12N9/20 , C12Y301/04003
摘要： The present invention relates to isolated polypeptides having phospholipase C activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译： 本发明涉及具有磷脂酶C活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。
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3.发明申请公开(公告)号：US20100120642A1
公开(公告)日：2010-05-13
申请号：US12270235
申请日：2008-11-13
申请人： Stephen Joseph Miller , Saleh A. Elomari , Zhen Zhou , Jesper Brask , Kim Borch
发明人： Stephen Joseph Miller , Saleh A. Elomari , Zhen Zhou , Jesper Brask , Kim Borch
IPC分类号： C10M129/72 , C12P7/62
CPC分类号： C12P7/62 , C07C29/00 , C07C67/08 , C10M129/72 , C10M177/00 , C10M2207/2835 , C10N2220/022 , C10N2220/023 , C12P17/02
摘要： The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via esterification of epoxide intermediates, and wherein the epoxide intermediates are generated via an enzymatically-driven mechanism. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.
摘要翻译： 本发明一般涉及制备二酯基润滑剂组合物的方法，其中二酯物质的形成通过环氧化物中间体的酯化进行，并且其中环氧化物中间体通过酶促驱动的机理产生。 在一些实施方案中，制备这种基于二酯的润滑剂的方法利用生物质前体和/或低价值（例如费 - 托（FT）烯烃和/或醇），以便产生高价值的基于二酯的润滑剂。 在一些实施方案中，这种基于二酯的润滑剂衍生自FT烯烃和脂肪酸。 脂肪酸可以来自生物基源（即生物质，可再生能源），或者可以通过氧化从FT醇衍生。
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4.发明申请公开(公告)号：US20150140623A1
公开(公告)日：2015-05-21
申请号：US14605882
申请日：2015-01-26
申请人： Stephen Joseph Miller , Saleh Ali Elomari , Zhen Zhou , Jesper Brask , Kim Borch
发明人： Stephen Joseph Miller , Saleh Ali Elomari , Zhen Zhou , Jesper Brask , Kim Borch
CPC分类号： C12P7/62 , C07C29/00 , C07C67/08 , C10M129/72 , C10M177/00 , C10M2207/2835 , C10N2220/022 , C10N2220/023 , C12P17/02
摘要： The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via esterification of epoxide intermediates, and wherein the epoxide intermediates are generated via an enzymatically-driven mechanism. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.
摘要翻译： 本发明一般涉及制备二酯基润滑剂组合物的方法，其中二酯物质的形成通过环氧化物中间体的酯化进行，并且其中环氧化物中间体通过酶促驱动的机理产生。 在一些实施方案中，制备这种基于二酯的润滑剂的方法利用生物质前体和/或低价值（例如费 - 托（FT）烯烃和/或醇），以便产生高价值的基于二酯的润滑剂。 在一些实施方案中，这种基于二酯的润滑剂衍生自FT烯烃和脂肪酸。 脂肪酸可以来自生物基源（即生物质，可再生能源），或者可以通过氧化从FT醇衍生。
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公开(公告)号：US20100047836A1
公开(公告)日：2010-02-25
申请号：US12515686
申请日：2007-11-26
申请人： Leonardo De Maria , Jesper Brask , Michael Skjot , Shamkant Anant Patkar , Kim Borch , Allan Svendsen
发明人： Leonardo De Maria , Jesper Brask , Michael Skjot , Shamkant Anant Patkar , Kim Borch , Allan Svendsen
CPC分类号： C12N9/20 , C12P7/40 , C12P7/62 , C12P7/6418 , C12Y301/01003
摘要： Molecular dynamics (MD) simulation on the three-dimensional structure of Candida anrtarctica lipase B revealed two hitherto unknown lids with a marked mobility, and this discovery was used to design lipolytic enzyme variants with increased lipolytic enzyme activity.
摘要翻译： 针对念珠菌脂肪酶B的三维结构的分子动力学（MD）模拟显示两个具有明显迁移率的未知盖，并且该发现用于设计具有增加的脂肪分解酶活性的脂肪分解酶变体。
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6.发明授权公开(公告)号：US09109238B2
公开(公告)日：2015-08-18
申请号：US12270235
申请日：2008-11-13
申请人： Stephen Joseph Miller , Saleh A. Elomari , Zhen Zhou , Jesper Brask , Kim Borch
发明人： Stephen Joseph Miller , Saleh A. Elomari , Zhen Zhou , Jesper Brask , Kim Borch
IPC分类号： C12P7/62 , C10M129/72 , C10M177/00 , C12P17/02
CPC分类号： C12P7/62 , C07C29/00 , C07C67/08 , C10M129/72 , C10M177/00 , C10M2207/2835 , C10N2220/022 , C10N2220/023 , C12P17/02
摘要： The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via esterification of epoxide intermediates, and wherein the epoxide intermediates are generated via an enzymatically-driven mechanism. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.
摘要翻译： 本发明一般涉及制备二酯基润滑剂组合物的方法，其中二酯物质的形成通过环氧化物中间体的酯化进行，并且其中环氧化物中间体通过酶促驱动的机理产生。 在一些实施方案中，制备这种基于二酯的润滑剂的方法利用生物质前体和/或低价值（例如费 - 托（FT）烯烃和/或醇），以便产生高价值的基于二酯的润滑剂。 在一些实施方案中，这种基于二酯的润滑剂衍生自FT烯烃和脂肪酸。 脂肪酸可以来自生物基源（即生物质，可再生能源），或者可以通过氧化从FT醇衍生。
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7.发明授权Lipolytic enzyme variant with improved stability and polynucleotides encoding same 有权具有改善稳定性的脂肪分解酶变体和编码相同的多核苷酸公开(公告)号：US09163203B2
公开(公告)日：2015-10-20
申请号：US12393512
申请日：2009-02-26
申请人： Jesper Vind , Kim Borch , Allan Svendsen , Robert Van der Lans , Lise Munch Mikkelsen , Christian Isak Jorgensen , Shamkant Anant Patkar
发明人： Jesper Vind , Kim Borch , Allan Svendsen , Robert Van der Lans , Lise Munch Mikkelsen , Christian Isak Jorgensen , Shamkant Anant Patkar
CPC分类号： C11D3/38627 , C12N9/20 , C12N15/00
摘要： The invention provides lipolytic enzyme variants having improved in-detergent stability and polynucleotides encoding same. Lipolytic enzyme variants with improved in-detergent stability are obtained by substituting certain specified amino acid residues in a parent lipolytic enzyme.
摘要翻译： 本发明提供具有改进的洗涤剂稳定性的脂肪分解酶变体和编码它的多核苷酸。 通过用母体脂肪分解酶中的某些特定的氨基酸残基取代具有改善的洗涤剂稳定性的脂肪分解酶变体。
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8.发明授权公开(公告)号：US08679813B2
公开(公告)日：2014-03-25
申请号：US12762586
申请日：2010-04-19
CPC分类号： C12N9/20
摘要： The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.
摘要翻译： 本发明涉及具有脂肪酶活性的多肽，并且在说明书中给出的测试条件下进一步具有至少0.8的RP和至少1.1的BR。
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公开(公告)号：US08288510B2
公开(公告)日：2012-10-16
申请号：US12433266
申请日：2009-04-30
申请人： Leonardo de Naria , Ming Li , Christian Isak Joergensen , Kim Borch , Tom Anton Busk Nielsen , Jesper Vind
发明人： Leonardo de Naria , Ming Li , Christian Isak Joergensen , Kim Borch , Tom Anton Busk Nielsen , Jesper Vind
CPC分类号： C07K14/37 , C07K2299/00 , C12N9/20
摘要： The invention provides for isolated peptides having phospholipase inhibitory activity, polypeptides comprising phospholipase inhibitory activity and lipases capable of being inhibited by the isolated peptides and/or polypeptides comprising phospholipase inhibitory activity. The invention also relates to nucleic acid constructs, recombinant expression vectors, and recombinant host cells comprising the polynucleotides as well as methods for producing and using the peptides and the polypeptides having lipase inhibitory activity.
摘要翻译： 本发明提供了具有磷脂酶抑制活性的分离肽，包含磷脂酶抑制活性的多肽和能够被包含磷脂酶抑制活性的分离的肽和/或多肽抑制的脂肪酶。 本发明还涉及核酸构建体，重组表达载体和包含多核苷酸的重组宿主细胞以及用于产生和使用具有脂肪酶抑制活性的肽和多肽的方法。
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公开(公告)号：US20120192316A1
公开(公告)日：2012-07-26
申请号：US13440626
申请日：2012-04-05
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
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