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公开(公告)号：US20100159486A1
公开(公告)日：2010-06-24
申请号：US12513032
申请日：2007-11-01
申请人： Lance A. Liotta , Wediong Zhou , Wolff Kirsch , Virginia Espina , Emanuel Petricoin, III , Mark Ross , Claudius Mueller , Shino Magaki
发明人： Lance A. Liotta , Wediong Zhou , Wolff Kirsch , Virginia Espina , Emanuel Petricoin, III , Mark Ross , Claudius Mueller , Shino Magaki
IPC分类号： G01N33/53 , C12Q1/02 , G01N33/566 , G01N33/00 , C07K16/18
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/2871
摘要： Low molecular weight (LMW) peptides have been discovered that are indicative of neurological conditions, such as Alzheimer's Disease (AD), cognitive impairment and brain microhemmorhages. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting neurological conditions and monitoring the progression of the disease. The LMW peptides are particularly useful in detecting neurological conditions during the early stages without invasive procedures.
摘要翻译： 已经发现了低分子量（LMW）肽，其指示诸如阿尔茨海默氏病（AD），认知障碍和脑微血管损伤之类的神经病学状况。 评估患者样本中存在这样的LMW肽是检测神经系统疾病和监测疾病进展的有效手段。 LMW肽特别可用于在早期阶段检测神经系统疾病而无侵入性手术。
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2.发明申请INHIBITION OF BRAIN ENZYMES INOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION 审中-公开脑损伤后脑组织中脑组织的抑制作用公开(公告)号：US20110250260A1
公开(公告)日：2011-10-13
申请号：US13035658
申请日：2011-02-25
IPC分类号： A61K31/713 , A61P25/28 , A61K9/127
CPC分类号： C12N15/1137 , A61K31/409 , C12N2310/14 , C12N2320/32 , C12Y114/99003
摘要： A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrinan in a manner that permits access to brain sites and/or the macula of the patient.
摘要翻译： 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括将含有siRNA的组合物给予血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂 ，胱天蛋白酶抑制剂或金属卟啉蛋白，其允许进入患者的脑部位和/或黄斑。
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3.发明申请INHIBITION OF BRAIN ENZYMES INVOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION 审中-公开参与谷氨酰胺转氨酶和谷氨酸降解的脑酶的抑制作用公开(公告)号：US20100047336A1
公开(公告)日：2010-02-25
申请号：US12542635
申请日：2009-08-17
IPC分类号： A61K9/127 , A61K31/7052 , A61K31/555 , A61P25/28
CPC分类号： C12N15/1137 , A61K31/409 , C12N2310/14 , C12N2320/32 , C12Y114/99003
摘要： A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.
摘要翻译： 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括将含有siRNA的组合物给予血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂 ，胱天蛋白酶抑制剂或金属卟啉以允许接近患者的脑部位和/或黄斑的方式。
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4.发明申请INHIBITION OF BRAIN ENZYMES INVOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION 审中-公开参与谷氨酰胺转氨酶和谷氨酸降解的脑酶的抑制作用公开(公告)号：US20090018094A1
公开(公告)日：2009-01-15
申请号：US11948856
申请日：2007-11-30
IPC分类号： A61K31/7105 , A61P25/28
CPC分类号： C12N15/1137 , A61K31/409 , C12N2310/14 , C12N2320/32 , C12Y114/99003
摘要： A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.
摘要翻译： 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括将含有siRNA的组合物给予血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂 ，胱天蛋白酶抑制剂或金属卟啉以允许接近患者的脑部位和/或黄斑的方式。
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5.发明授权公开(公告)号：US07316705B2
公开(公告)日：2008-01-08
申请号：US11064393
申请日：2005-02-22
申请人： Wolff Kirsch , Yong Hua Zhu , Cindy Dickson
发明人： Wolff Kirsch , Yong Hua Zhu , Cindy Dickson
CPC分类号： A61L24/0015 , A61B17/085 , A61B2017/081 , A61F13/023 , A61F13/0246 , A61L2/00 , A61L15/58 , A61L24/06 , C08L35/04
摘要： The present invention provides a device and method for safely applying cyanoacrylate or other adhesives to skin lacerations.
摘要翻译： 本发明提供了一种用于将氰基丙烯酸酯或其它粘合剂安全施用于皮肤撕裂的装置和方法。
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公开(公告)号：US20070123816A1
公开(公告)日：2007-05-31
申请号：US11544793
申请日：2006-10-05
申请人： Yong Zhu , Wolff Kirsch
发明人： Yong Zhu , Wolff Kirsch
IPC分类号： A61M31/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/0206 , A61B17/3439 , A61B2017/00243 , A61B2017/00292 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00862 , A61B2017/00884 , A61B2017/00942 , A61B2090/037 , A61M25/0668 , A61M2025/0681
摘要： A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. A blocking member distal of the hemostatic material functions as a barrier to prevent the hemostatic material from entering the wound. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.
摘要翻译： 用于闭合血管伤口的方法和装置包括可以在导线上或与伤口相邻就位的导线上穿过的装置。 该装置包括在其中封闭止血材料的腔室。 当根据需要将装置定位在伤口附近时，止血材料从腔室展开。 止血材料远端的阻塞构件用作防止止血材料进入伤口的屏障。 血液接触止血材料，血液凝固优选由材料内的止血剂促进。 因此，血管穿刺伤口被血块形成密封。
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公开(公告)号：US20060064124A1
公开(公告)日：2006-03-23
申请号：US11280029
申请日：2005-11-15
申请人： Yong Zhu , Wolff Kirsch
发明人： Yong Zhu , Wolff Kirsch
IPC分类号： A61B17/08
CPC分类号： A61B17/10 , A61B17/0057 , A61B17/02 , A61B17/0206 , A61B17/0682 , A61B17/08 , A61B17/122 , A61B17/128 , A61B17/3439 , A61B2017/306 , B29K2067/003
摘要： An apparatus is provided for facilitating the locating and closing of an opening in a blood vessel. The apparatus includes a catheter and retractor that are advanced over a guidewire until they are positioned at or adjacent the vascular wound. The retractor comprises a plurality of members that close upon and engage the catheter. A coupling member selectively maintains the retractor members in the closed position.
摘要翻译： 提供了一种便于定位和关闭血管中的开口的装置。 该装置包括一导管和牵开器，该导管和牵开器在引导线上前进，直到其定位在血管伤口处或其附近。 牵开器包括靠近并接合导管的多个构件。 联接构件选择性地将牵开器构件保持在关闭位置。
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8.发明申请Antibodies to iron regulating protein -2 (IRP-2) as a diagnostic for neurodegenerative disease 审中-公开铁调节蛋白-2（IRP-2）作为神经变性疾病诊断的抗体公开(公告)号：US20050260669A1
公开(公告)日：2005-11-24
申请号：US11174166
申请日：2005-07-01
申请人： Wolff Kirsch , Anton Lennart , Wayne Kelln , Dae-Kyung Kang , Rodney Levine , Tracey Rouault
发明人： Wolff Kirsch , Anton Lennart , Wayne Kelln , Dae-Kyung Kang , Rodney Levine , Tracey Rouault
IPC分类号： C12N15/09 , C07K14/00 , C07K14/47 , C07K16/18 , C12P21/08 , C12Q1/68 , C12Q1/6883 , G01N33/53 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： G01N33/6896 , C07K14/4702 , C07K16/18 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/04 , G01N2800/2821
摘要： The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's disease. Embodiments include nucleic acids that encode mutant IRP-2 proteins and fragments thereof, mutant IRP-2 proteins and fragments thereof, antibodies directed to epitopes present on mutant IRP-2 proteins and fragments thereof, methods of making these nucleic acids and polypeptides, as well as, approaches to diagnose neurodegenerative disease in animals, such as humans at risk of contracting Alzheimer's disease.
摘要翻译： 本发明涉及神经变性疾病标记物的发现。 更具体地，已经发现，不能在关键半胱氨酸残基处经历氧化的IRP-2蛋白的形式是神经变性疾病的诊断，包括但不限于阿尔茨海默病。 实施方案包括编码突变体IRP-2蛋白及其片段，突变体IRP-2蛋白及其片段的核酸，针对存在于突变体IRP-2蛋白及其片段上的表位的抗体，以及制备这些核酸和多肽的方法 作为诊断动物中的神经变性疾病的方法，例如患有阿尔茨海默病的风险的人。
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公开(公告)号：US20050240137A1
公开(公告)日：2005-10-27
申请号：US11061243
申请日：2005-02-18
申请人： Yong Zhu , Chang Yang , Wolff Kirsch
发明人： Yong Zhu , Chang Yang , Wolff Kirsch
CPC分类号： A61L15/28 , A61B17/0057 , A61B17/06166 , A61B2017/00526 , A61B2017/00623 , A61B2017/00884 , A61B2017/00898 , A61L26/0023 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers. The hemostatic materials are suitable for use in sealing or controlling active bleeding from artery and vein lacerations and punctures, and for controlling oozing from tissue.
摘要翻译： 本发明涉及包含壳聚糖纤维的可展开的止血材料。 止血材料适合用于密封或控制动脉和静脉撕裂和穿刺的活动性渗血，并用于控制从组织渗出。
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公开(公告)号：US20050123588A1
公开(公告)日：2005-06-09
申请号：US10868201
申请日：2004-06-14
申请人： Yong Zhu , Chang Yang , Wolff Kirsch , Qun-Dong Shen , Yong Hu , Cindy Dickson
发明人： Yong Zhu , Chang Yang , Wolff Kirsch , Qun-Dong Shen , Yong Hu , Cindy Dickson
CPC分类号： A61K9/70 , A61B17/0057 , A61B17/06166 , A61B2017/00884 , A61B2017/00898 , A61K47/36 , A61L15/225 , A61L26/0052 , A61L26/0066 , A61L2300/232 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/622 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers upon which hemostatic microporous polysaccharide microspheres and a medicament or biologically active substance are deposited. The hemostatic materials are suitable for use in controlling active bleeding from artery and vein lacerations, sealing femoral artery punctures, and controlling oozing from tissue.
摘要翻译： 本发明涉及包含壳聚糖纤维的可部署止血材料，其上沉积有止血微孔多糖微球和药物或生物活性物质。 止血材料适用于控制动脉和静脉撕裂的活动性出血，密封股动脉穿刺，以及控制组织渗出。
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