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公开(公告)号：US20050171163A1
公开(公告)日：2005-08-04
申请号：US10442917
申请日：2003-05-21
申请人： Larry Bratton , Alexander Bridges , David Connor , Steven Miller , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
发明人： Larry Bratton , Alexander Bridges , David Connor , Steven Miller , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
IPC分类号： C07D233/64 , A61K31/10 , A61K31/121 , A61K31/167 , A61K31/22 , A61K31/341 , A61K31/381 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/4402 , A61K31/4439 , A61P9/10 , A61P19/02 , A61P29/00 , A61P37/06 , A61P43/00 , C07C311/03 , C07C311/27 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C323/22 , C07D213/44 , C07D213/50 , C07D233/54 , C07D239/26 , C07D261/08 , C07D263/32 , C07D277/10 , C07D277/26 , C07D307/40 , C07D307/46 , C07D307/71 , C07D307/80 , C07D333/18 , C07D333/22 , C07D333/38 , C07D333/44 , C07D413/02 , C07D413/04
CPC分类号： C07C311/03 , C07C311/27 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07D213/50 , C07D233/64 , C07D239/26 , C07D261/08 , C07D263/32 , C07D277/10 , C07D277/26 , C07D307/46 , C07D307/71 , C07D307/80 , C07D333/22 , C07D333/38 , C07D333/44 , C07D413/04
摘要： The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists.
摘要翻译： 本发明涉及可用于治疗趋化因子介导的病症的砜。 在某些实施方案中，本发明涉及作为MCP-1受体拮抗剂的化合物。
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2.发明申请公开(公告)号：US20100261729A1
公开(公告)日：2010-10-14
申请号：US12795986
申请日：2010-06-08
IPC分类号： A61K31/497 , A61P15/10
CPC分类号： A61K31/085 , A61K9/00 , A61K31/075 , A61K31/135 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/53
摘要： A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.
摘要翻译： 治疗勃起功能障碍（ED）的方法包括以有效提高受试者睾酮水平的量给予有需要的受试者的fispemifene的步骤。 在与常规ED治疗没有足够反应的个体中，可以将fispemifene与PDE-5抑制剂组合使用。 还公开了通过与PDE-5抑制剂组合施用克洛米芬，enclomifene，ospemifene，托瑞米芬及其混合物来治疗ED的方法。
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3.发明申请4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 审中-公开4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US20050049429A1
公开(公告)日：2005-03-03
申请号：US10967427
申请日：2004-10-18
申请人： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
发明人： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
IPC分类号： C07C259/10 , C07D211/22 , C07D295/088 , C07D307/42 , C07D309/06 , C07D333/16 , C07C239/22
CPC分类号： C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
摘要： Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
摘要翻译： 下式的苯基氨基苯并肟酸衍生物其中R 1，R 2，R 3，R 4，R 5和R 6是氢或取代基如烷基，并且其中R 7是氢或有机基团是MEK的有效抑制剂，因此是 有效治疗癌症和其他增殖性疾病如牛皮癣和再狭窄。
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4.发明申请公开(公告)号：US20130217696A1
公开(公告)日：2013-08-22
申请号：US13848325
申请日：2013-03-21
IPC分类号： A61K31/085 , A61K31/519 , A61K31/4985
CPC分类号： A61K31/085 , A61K9/00 , A61K31/075 , A61K31/135 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/53
摘要： A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.
摘要翻译： 治疗勃起功能障碍（ED）的方法包括以有效提高受试者睾酮水平的量给予有需要的受试者的fispemifene的步骤。 在与常规ED治疗没有足够反应的个体中，可以将fispemifene与PDE-5抑制剂组合使用。 还公开了通过与PDE-5抑制剂组合施用克洛米芬，enclomifene，ospemifene，托瑞米芬及其混合物来治疗ED的方法。
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5.发明申请4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 失效4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US20060052608A1
公开(公告)日：2006-03-09
申请号：US11249543
申请日：2005-10-12
申请人： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
发明人： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
IPC分类号： C07D221/02 , C07C259/04
CPC分类号： C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
摘要： Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
摘要翻译： 苯基氨基苯肟酸衍生物
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6.发明申请Phosphorus containing compounds useful for the regulation of LDL and Lp(a) levels 审中-公开含磷化合物可用于调节LDL和Lp（a）水平公开(公告)号：US20050143349A1
公开(公告)日：2005-06-30
申请号：US11011965
申请日：2004-12-14
申请人： Alexander Bridges
发明人： Alexander Bridges
IPC分类号： A61K31/67 , A61K31/675 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/6558 , C07F9/6568 , C07F9/6571 , C07F9/6578 , C07F9/6584
CPC分类号： C07F9/65685 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/650905 , C07F9/65583 , C07F9/65586 , C07F9/657181 , C07F9/65719 , C07F9/65785 , C07F9/65842 , C07F9/65848
摘要： The invention provides phosphorus containing compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds to a subject, wherein the phosphorus containing compounds are of the Formula I: wherein B1, B2, B3, B4, Ar, F, E, G, Y1, Y2, Y3, X, U, V, R4, R5, Q, D, n, Het, Z1, and Z2, are as defined herein.
摘要翻译： 本发明提供含磷化合物，包含该化合物的药物组合物，以及向受试者施用化合物的方法，其中含磷化合物具有式I：其中B 1，B 2， B，S 4，B 4，Ar，F，E，G，Y 1，Y 2， X，U，V，R 4，R 5，Q，D，n，Het，Z 1 和Z <2>如本文所定义。
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7.发明申请公开(公告)号：US20080312239A1
公开(公告)日：2008-12-18
申请号：US12138560
申请日：2008-06-13
IPC分类号： A61K31/53 , A61K31/085 , A61K31/135 , A61P15/00 , A61K31/4985 , A61K31/496
CPC分类号： A61K31/085 , A61K9/00 , A61K31/075 , A61K31/135 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/53
摘要： A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.
摘要翻译： 治疗勃起功能障碍（ED）的方法包括以有效提高受试者睾酮水平的量给予有需要的受试者的fispemifene的步骤。 在与常规ED治疗没有足够反应的个体中，可以将fispemifene与PDE-5抑制剂组合使用。 还公开了通过与PDE-5抑制剂组合施用克洛米芬，enclomifene，ospemifene，托瑞米芬及其混合物来治疗ED的方法。
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公开(公告)号：US5340833A
公开(公告)日：1994-08-23
申请号：US877664
申请日：1992-05-01
IPC分类号： A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4436 , A61P9/00 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D333/58 , C07D333/62 , C07D333/66 , C07D333/68 , C07D333/74 , C07D409/04 , C07D409/06 , C07D409/14 , C07D495/04
CPC分类号： C07D409/04 , C07D333/74 , C07D409/06 , C07D409/14 , C07D495/04
摘要： Disclosed are benzothiophene and thienothiophene derivatives useful for inhibiting urokinase activity.
摘要翻译： 公开了可用于抑制尿激酶活性的苯并噻吩和噻吩并噻吩衍生物。
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