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公开(公告)号：US08420632B2
公开(公告)日：2013-04-16
申请号：US13381234
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlène Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlène Schuppli
IPC分类号： A61K31/551 , A61K31/4965 , A61K31/497 , C07D295/26 , C07D471/04 , C07D413/12 , C07D401/12 , C07D403/12
CPC分类号： C07D215/14 , A61K31/4965 , A61K31/497 , A61K31/551 , C07D209/10 , C07D209/12 , C07D209/20 , C07D209/24 , C07D209/26 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/68 , C07D261/20 , C07D295/15 , C07D295/26 , C07D471/04 , Y02A50/411
摘要： Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
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2.发明申请NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS 有权新型苯并噻二唑化合物，其合成方法及其在医药中的用途如同化妆品公开(公告)号：US20120323006A1
公开(公告)日：2012-12-20
申请号：US13381234
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlene Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlene Schuppli
IPC分类号： C07D295/26 , C07D471/04 , C07D413/12 , C07D401/12 , C07D403/12
CPC分类号： C07D215/14 , A61K31/4965 , A61K31/497 , A61K31/551 , C07D209/10 , C07D209/12 , C07D209/20 , C07D209/24 , C07D209/26 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/68 , C07D261/20 , C07D295/15 , C07D295/26 , C07D471/04 , Y02A50/411
摘要： Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
摘要翻译： 描述具有式（I）结构的苯磺酰胺化合物。 还描述了用于合成化合物的方法及其在人或兽医学药物组合物和化妆品组合物中的用途。
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3.发明授权3-phenyl acrylic acid compound activators of type PPAR receptors and pharmaceutical/cosmetic compositions comprised thereof 失效类型PPAR受体的3-苯基丙烯酸化合物活化剂和由其组成的药物/化妆品组合物公开(公告)号：US08404836B2
公开(公告)日：2013-03-26
申请号：US12632257
申请日：2009-12-07
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07C309/65 , A61K8/365 , A61K8/42 , A61K8/466 , A61Q5/02 , A61Q19/10 , C07C59/68 , C07C217/76 , C07C233/25 , C07C235/56 , C07C309/66 , C07C309/67 , C07C311/08 , C07C311/13
摘要： Novel 3-phenyl acrylic acid compounds have the following general formula (I): and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, as well as in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or into cosmetic compositions.
摘要翻译： 新型3-苯基丙烯酸化合物具有以下通式（I）：并配制成用于人或兽医药物（皮肤病学以及心血管疾病，免疫疾病和/或相关疾病）领域的药物组合物 与脂质代谢）或化妆品组合物。
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4.发明授权3-phenylpropanoic compound activators of receptors of PPAR type and pharmaceutical/cosmetic compositions comprised thereof 失效PPAR型受体的3-苯基丙酸化合物活化剂及其组成的药物/化妆品组合物公开(公告)号：US07879907B2
公开(公告)日：2011-02-01
申请号：US12632159
申请日：2009-12-07
IPC分类号： A61K31/235 , A61K31/185 , C07C317/14 , C07C69/76 , C07C229/00 , C07C59/00 , C07C65/01
CPC分类号： C07C309/66 , C07C59/68 , C07C69/017 , C07C69/734 , C07C233/54 , C07C233/55 , C07C309/65 , C07C309/71 , C07C311/32 , C07C311/35 , C07C2601/14
摘要： Novel 3-phenylpropanoic acid compounds have the general formula (I) below: and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or lipid metabolism-related diseases), or, alternatively, into cosmetic compositions.
摘要翻译： 新型3-苯基丙酸化合物具有以下通式（I）：并配制成用于人或兽医药物（皮肤病学以及心血管疾病，免疫疾病和/或脂质代谢相关的领域）的药物组合物 疾病），或者替代为化妆品组合物。
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5.发明授权4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases 有权4-烷氧基-N-（2-羟基氨基甲酰基-2-哌啶基 - 乙基） - 苯甲酰胺化合物作为治疗炎性疾病的选择性TACE-抑制剂公开(公告)号：US09266848B2
公开(公告)日：2016-02-23
申请号：US13496577
申请日：2010-09-16
申请人： Laurence Clary , Jean-Claude Pascal
发明人： Laurence Clary , Jean-Claude Pascal
IPC分类号： C07D295/15 , C07D213/30 , C07D213/61 , C07D215/14 , C07D267/22 , C07D401/12 , C07D403/12 , C07D471/04
CPC分类号： C07D295/15 , C07D213/30 , C07D213/61 , C07D215/14 , C07D267/22 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I) below: and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.
摘要翻译： 本发明涉及具有对应于下列通式（I）的结构的新型苯 - 甲酰胺化合物：以及它们的合成方法及其在预期用于人或兽医学的药物组合物中的用途， 用于化妆品组合物。
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6.发明申请4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权作为治疗炎症性疾病的选择性抑制剂的4-烷氧基-N-（2-羟基卡巴酰亚氨基-2-哌啶-1-基） - 苯甲酰胺化合物公开(公告)号：US20120226033A1
公开(公告)日：2012-09-06
申请号：US13496577
申请日：2010-09-16
申请人： Laurence Clary , Jean-Claude Pascal
发明人： Laurence Clary , Jean-Claude Pascal
IPC分类号： C07D401/12 , C07D267/22 , C07D417/12 , C07D471/04 , C07D295/15 , C07D413/12
CPC分类号： C07D295/15 , C07D213/30 , C07D213/61 , C07D215/14 , C07D267/22 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I) below: and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.
摘要翻译： 本发明涉及具有对应于下列通式（I）的结构的新型苯 - 甲酰胺化合物：以及它们的合成方法及其在预期用于人或兽医学的药物组合物中的用途， 用于化妆品组合物。
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7.发明申请NOVEL 3-PHENYLPROPANOIC COMPOUND ACTIVATORS OF RECEPTORS OF PPAR TYPE AND PHARMACEUTICAL/COSMETIC COMPOSITIONS COMPRISED THEREOF 失效PPAR类型及其包含的药物/化妆品组合物的新型3-苯基丙烯酸酯化合物活化剂公开(公告)号：US20100158843A1
公开(公告)日：2010-06-24
申请号：US12632159
申请日：2009-12-07
IPC分类号： A61K8/36 , C07C59/01 , C07C69/708 , A61K8/37 , A61Q19/00 , A61Q5/00 , A61K31/192 , A61P17/10 , A61K31/216 , A61P35/00 , A61P3/10 , A61P3/04 , A61P3/06 , A61P17/14 , A61P37/00
CPC分类号： C07C309/66 , C07C59/68 , C07C69/017 , C07C69/734 , C07C233/54 , C07C233/55 , C07C309/65 , C07C309/71 , C07C311/32 , C07C311/35 , C07C2601/14
摘要： Novel 3-phenylpropanoic acid compounds have the general formula (I) below: and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or lipid metabolism-related diseases), or, alternatively, into cosmetic compositions.
摘要翻译： 新型3-苯基丙酸化合物具有以下通式（I）：并配制成用于人或兽医药物（皮肤病学以及心血管疾病，免疫疾病和/或脂质代谢相关的领域）的药物组合物 疾病），或者替代为化妆品组合物。
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8.发明授权Oxoazetidine derivatives, process for the preparation thereof and use thereon in human medicine and in cosmetics 有权氧氮杂环丁啶衍生物，其制备方法及其在人类药物和化妆品中的用途公开(公告)号：US08871187B2
公开(公告)日：2014-10-28
申请号：US13127643
申请日：2009-11-04
IPC分类号： A61K31/4178 , C07D403/12 , C07D401/12 , A61Q5/10 , A61Q17/04 , A61Q19/00 , A61Q19/04 , A61Q19/02 , A61K8/49
CPC分类号： C07D403/12 , A61K8/4906 , A61K8/494 , A61K31/4178 , A61K2800/78 , A61Q5/10 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/008 , A61Q19/02 , A61Q19/04 , C07D401/12 , Y02A50/463
摘要： Compounds derived from oxoazetidine corresponding to general formula (I) compositions containing same, processes for their preparation and their use in pharmaceutical or cosmetic compositions are described.
摘要翻译： 描述了衍生自对应于通式（I）的含氮氮杂环丁烷的化合物，其含有它们的组合物，其制备方法及其在药物或化妆品组合物中的应用。
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![Preparation of 3-[5′-(3,4-bis(hydroxymethyl)benzyloxy)-2′-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol](/abs-image/US/2009/12/29/US07638657B2/abs.jpg.150x150.jpg)
9.发明授权Preparation of 3-[5′-(3,4-bis(hydroxymethyl)benzyloxy)-2′-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol 失效制备3- [5' - （3,4-双（羟甲基）苄氧基）-2'-乙基-2-丙基联苯-4-基]戊-3-醇公开(公告)号：US07638657B2
公开(公告)日：2009-12-29
申请号：US11802029
申请日：2007-05-18
CPC分类号： C07C41/26 , C07C37/20 , C07C39/12 , C07C45/673 , C07C45/71 , C07C49/83 , C07C49/84 , C07C43/23
摘要： 3-[5′-(3,4-bis(hydroxymethyl)benzyloxy)-2′-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol is prepared from the novel intermediate, 6-ethyl-4′-(1-ethyl-1-hydroxypropyl)-2′-propylbiphenyl-3-ol.
摘要翻译： 由新型中间体6-乙基-4'-氧代-3,4-二氢吡啶制备3- [5' - （3,4-双（羟甲基）苄氧基）-2'-乙基-2-丙基联苯-4-基]戊-3-醇， （1-乙基-1-羟丙基）-2'-丙基联苯-3-醇。
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10.发明授权Dibenzoyl peroxide derivatives, preparation method thereof and cosmetic or dermatological compositions containing same 有权二苯甲酰基过氧化物衍生物，其制备方法和含有它们的化妆品或皮肤病学组合物公开(公告)号：US08901357B2
公开(公告)日：2014-12-02
申请号：US13519871
申请日：2010-12-22
IPC分类号： C07C409/32 , A61K31/075 , C07C409/34
CPC分类号： C07C409/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74
摘要： The use of compounds in the treatment of skin disorders is described. In particular, compounds having the general formula (I): are described. A process for preparing such compounds and their cosmetic or dermatological use are also described.The described compounds can act as bactericides. As a result, they can be useful in the treatment of conditions associated with the presence of bacteria, more specifically of P. acnes.
摘要翻译： 描述了化合物在治疗皮肤病中的用途。 特别地，描述了具有通式（I）的化合物。 还描述了制备这些化合物及其化妆品或皮肤病学用途的方法。 所述的化合物可以作为杀菌剂。 因此，它们可用于治疗与细菌存在相关的病症，特别是痤疮丙酸杆菌。
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