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    Frequency domain analysis to detect T wave oversensing
    1.
    发明授权
    Frequency domain analysis to detect T wave oversensing 有权
    频域分析以检测T波超检测

    公开(公告)号：US08386033B2

    公开(公告)日：2013-02-26

    申请号：US12607847

    申请日：2009-10-28

    申请人： Laurence S. Sloman ,  Stuart Rosenberg

    发明人： Laurence S. Sloman ,  Stuart Rosenberg

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3702 ,  A61B5/0452 ,  A61B5/7257 ,  A61B5/726 ,  A61N1/37

    摘要： Detection of T wave oversensing in an ICD is accomplished in order to prevent improper application of treatment to a patient. The ICD device senses for electrical impulses representing the R waves of a beating heart. In some instances the ICD device will sense T waves that it will assume to be R waves, because the ICD device expects or assumes that such sensed signals are R waves. Time intervals between each detected, assumed R waves are measured and a list of intervals is generated. The list is transformed into its frequency domain equivalent and analyzed for peaks and randomness criteria to determine whether T wave oversensing has occurred.

    摘要翻译： 为了防止对患者的不适当的治疗应用，ICD中的T波超检测的检测是完成的。 ICD装置感测表示跳动心脏的R波的电脉冲。 在某些情况下，由于ICD设备预期或假设这些感测信号是R波，因此ICD设备将感测T波将被认为是R波。 测量每个检测到的假定R波之间的时间间隔，并产生间隔列表。 将该列表转换为其等效频域，并分析峰值和随机性标准，以确定是否发生了T波超检测。

    FREQUENCY DOMAIN ANALYSIS TO DETECT T WAVE OVERSENSING
    4.
    发明申请
    FREQUENCY DOMAIN ANALYSIS TO DETECT T WAVE OVERSENSING 有权
    频域分析，以检测T波浪监测

    公开(公告)号：US20110098764A1

    公开(公告)日：2011-04-28

    申请号：US12607847

    申请日：2009-10-28

    申请人： Laurence S. Sloman ,  Stuart Rosenberg

    发明人： Laurence S. Sloman ,  Stuart Rosenberg

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3702 ,  A61B5/0452 ,  A61B5/7257 ,  A61B5/726 ,  A61N1/37

    摘要： Detection of T wave oversensing in an ICD is accomplished in order to prevent improper application of treatment to a patient. The ICD device senses for electrical impulses representing the R waves of a beating heart. In some instances the ICD device will sense T waves that it will assume to be R waves, because the ICD device expects or assumes that such sensed signals are R waves. Time intervals between each detected, assumed R waves are measured and a list of intervals is generated. The list is transformed into its frequency domain equivalent and analyzed for peaks and randomness criteria to determine whether T wave oversensing has occurred.

    摘要翻译： 为了防止对患者的不适当的治疗应用，ICD中的T波超检测的检测是完成的。 ICD装置感测表示跳动心脏的R波的电脉冲。 在某些情况下，由于ICD设备预期或假设这些感测信号是R波，因此ICD设备将感测T波将被认为是R波。 测量每个检测到的假定R波之间的时间间隔，并产生间隔列表。 将该列表转换为其等效频域，并分析峰值和随机性标准，以确定是否发生了T波超检测。

    Systems and methods for determining pacing related parameters
    6.
    发明授权
    Systems and methods for determining pacing related parameters 有权
    用于确定起搏相关参数的系统和方法

    公开(公告)号：US09254391B2

    公开(公告)日：2016-02-09

    申请号：US13196580

    申请日：2011-08-02

    申请人： Kyungmoo Ryu ,  Tomas Svensson ,  Stuart Rosenberg

    发明人： Kyungmoo Ryu ,  Tomas Svensson ,  Stuart Rosenberg

    IPC分类号： A61N1/365 ,  A61N1/368 ,  A61N1/37

    CPC分类号： A61N1/3682 ,  A61N1/3684 ,  A61N1/371

    摘要： Pacing related timing is determined for an implantable medical device (IMD) by pacing at an RV pacing site, a first LV pacing site and a second LV pacing site in accordance with a first site, a second site and a third site pacing order, and further in accordance with a first inter-electrode pacing delay between pacing at the first site and pacing at the second site and a second inter-electrode pacing delay between pacing at the second site and pacing at the third site. At least one of a sensed event or a paced event is detected for at each of the second site and the third site. The first inter-electrode pacing delay and the second inter-electrode pacing delay are adjusted to avoid sensed events in favor of paced events at each of the second site and the third site. An atrio-ventricular delay may also be adjusted to avoid sensed events or lack of capture due to possible fusion at the first site, in favor of paced events at the first site.

    摘要翻译： 通过根据第一部位，第二部位和第三部位起搏顺序，在RV起搏部位，第一LV起搏部位和第二LV起搏部位进行起搏，确定可植入医疗装置（IMD）的起搏相关时间，以及 进一步根据在第一部位的起搏和第二部位的起搏之间的第一电极间起搏延迟和在第二部位起搏和第三部位起搏之间的第二电极间起搏延迟。 在第二站点和第三站点的每个处检测感测事件或起搏事件中的至少一个。 调整第一电极间起搏延迟和第二电极间起搏延迟以避免感测到的事件有利于在第二位置和第三位置的每一个处的起搏事件。 还可以调整心房延迟以避免感染事件或由于第一部位可能融合而导致的捕获不足，有利于在第一部位的起搏事件。

    Systems and methods for controlling spinal cord stimulation to improve stimulation efficacy for use by implantable medical devices
    7.
    发明授权
    Systems and methods for controlling spinal cord stimulation to improve stimulation efficacy for use by implantable medical devices 有权
    用于控制脊髓刺激以提高可植入医疗装置使用的刺激功效的系统和方法

    公开(公告)号：US09119965B2

    公开(公告)日：2015-09-01

    申请号：US13442749

    申请日：2012-04-09

    申请人： Cecilia Qin Xi ,  Stuart Rosenberg

    发明人： Cecilia Qin Xi ,  Stuart Rosenberg

    IPC分类号： A61N1/36 ,  A61N1/39 ,  A61N1/368

    CPC分类号： A61N1/36114 ,  A61N1/36139 ,  A61N1/3684 ,  A61N1/3962

    摘要： Techniques are provided for controlling spinal cord stimulation (SCS) or other forms of neurostimulation. In one example, SCS treatment is delivered to a patient and nerve impulse firing signals are sensed along the spinal cord following the SCS treatment. The nerve impulse signals are analyzed to determine whether the signals are associated with effective SCS and then the delivery of additional SCS is controlled to improve SCS efficacy. For example, the nerve impulse signals can be analyzed to determine whether the signals are consistent with a positive patient mood associated with pain mitigation and, if not, SCS control parameters are adjusted to improve the efficacy of the SCS in reducing pain. In other examples, heart rate variability (HRV) is also used to control SCS. Still further, adjustments may be made to SCS control parameters to improve antiarrhythmic or sympatholytic effects associated with SCS. Techniques employing baseline/target calibration procedures are also described.

    摘要翻译： 提供了用于控制脊髓刺激（SCS）或其他形式的神经刺激的技术。 在一个示例中，SCS治疗被递送给患者，并且在SCS治疗之后沿着脊髓感测神经脉冲激发信号。 分析神经脉冲信号以确定信号是否与有效的SCS相关联，然后控制附加SCS的递送以提高SCS功效。 例如，可以分析神经脉冲信号以确定信号是否与与疼痛缓解相关的阳性患者情绪一致，并且如果不是，则调整SCS控制参数以提高SCS在减轻疼痛中的功效。 在其他实例中，心率变异性（HRV）也用于控制SCS。 此外，可以调整SCS控制参数以改善与SCS相关的抗心律失常或交感神经效应。 还描述了使用基线/目标校准程序的技术。

    Determination of cardiac resynchronization therapy settings
    8.
    发明授权
    Determination of cardiac resynchronization therapy settings 有权
    心脏再同步治疗设置的测定

    公开(公告)号：US08798765B2

    公开(公告)日：2014-08-05

    申请号：US13471167

    申请日：2012-05-14

    申请人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

    发明人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

    IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N1/368

    CPC分类号： A61N1/36507 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/37252

    摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.

    摘要翻译： 用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。 基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。 从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。 该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

    SYSTEMS AND METHODS FOR CONTROLLING SPINAL CORD STIMULATION TO IMPROVE STIMULATION EFFICACY FOR USE BY IMPLANTABLE MEDICAL DEVICES
    9.
    发明申请
    SYSTEMS AND METHODS FOR CONTROLLING SPINAL CORD STIMULATION TO IMPROVE STIMULATION EFFICACY FOR USE BY IMPLANTABLE MEDICAL DEVICES 有权
    用于控制脊髓刺激的系统和方法，以提高通过可植入医疗器械使用的刺激效果

    公开(公告)号：US20130268016A1

    公开(公告)日：2013-10-10

    申请号：US13442749

    申请日：2012-04-09

    申请人： Cecilia Qin Xi ,  Stuart Rosenberg

    发明人： Cecilia Qin Xi ,  Stuart Rosenberg

    IPC分类号： A61N1/36 ,  A61N1/365

    CPC分类号： A61N1/36114 ,  A61N1/36139 ,  A61N1/3684 ,  A61N1/3962

    摘要： Techniques are provided for controlling spinal cord stimulation (SCS) or other forms of neurostimulation. In one example, SCS treatment is delivered to a patient and nerve impulse firing signals are sensed along the spinal cord following the SCS treatment. The nerve impulse signals are analyzed to determine whether the signals are associated with effective SCS and then the delivery of additional SCS is controlled to improve SCS efficacy. For example, the nerve impulse signals can be analyzed to determine whether the signals are consistent with a positive patient mood associated with pain mitigation and, if not, SCS control parameters are adjusted to improve the efficacy of the SCS in reducing pain. In other examples, heart rate variability (HPV) is also used to control SCS. Still further, adjustments may be made to SCS control parameters to improve antiarrhythmic or sympatholytic effects associated with SCS. Techniques employing baseline/target calibration procedures are also described.

    摘要翻译： 提供了用于控制脊髓刺激（SCS）或其他形式的神经刺激的技术。 在一个示例中，SCS治疗被递送给患者，并且在SCS治疗之后沿着脊髓感测神经脉冲激发信号。 分析神经脉冲信号以确定信号是否与有效的SCS相关联，然后控制附加SCS的递送以提高SCS功效。 例如，可以分析神经脉冲信号以确定信号是否与与疼痛缓解相关的阳性患者情绪一致，并且如果不是，则调整SCS控制参数以提高SCS在减轻疼痛中的功效。 在其他实例中，心率变异性（HPV）也用于控制SCS。 此外，可以调整SCS控制参数以改善与SCS相关的抗心律失常或交感神经效应。 还描述了使用基线/目标校准程序的技术。

    Methods and systems to monitor and identify transient ischemia
    10.
    发明授权
    Methods and systems to monitor and identify transient ischemia 有权
    监测和鉴别短暂性脑缺血的方法和系统

    公开(公告)号：US08447389B2

    公开(公告)日：2013-05-21

    申请号：US12861573

    申请日：2010-08-23

    申请人： Steve Koh ,  Michael Yang ,  Ryan Rooke ,  Stuart Rosenberg ,  Wenbo Hou

    发明人： Steve Koh ,  Michael Yang ,  Ryan Rooke ,  Stuart Rosenberg ,  Wenbo Hou

    IPC分类号： A61B5/0452

    CPC分类号： A61B5/0422 ,  A61B5/686 ,  A61B5/7282 ,  A61B2576/023 ,  A61N1/365 ,  A61N1/3702

    摘要： A system and method are provided for monitoring ischemic development. The system and method identify a non-physiologic event and obtain cardiac signals along multiple sensing vectors, wherein at least a portion of the sensing vectors extend to or from electrodes located proximate to the left ventricle. The system and method monitor a segment of interest in the cardiac signals obtained along the multiple sensing vectors to identify deviations in the segment of interest from a baseline. The system and method record at least one of timing or segment shift information associated with the deviations in the segments of interest; and identify at least one of size, direction of development or rate of progression of an ischemia region based on the at least one of timing or segment shift information.

    摘要翻译： 提供了一种用于监测缺血发育的系统和方法。 系统和方法识别非生理事件并且沿着多个感测向量获得心脏信号，其中至少一部分感测向量延伸到位于靠近左心室的电极。 系统和方法监测沿着多个感测向量获得的心脏信号中的感兴趣区段，以识别感兴趣区段中的偏离基线。 系统和方法记录与感兴趣的部分中的偏差相关联的定时或分段移位信息中的至少一个; 并且基于定时或段位移信息中的至少一个来识别缺血区域的大小，发育方向或进展速度中的至少一个。