-
公开(公告)号：US06964973B2
公开(公告)日：2005-11-15
申请号：US10299909
申请日：2002-11-18
申请人： Lin Zhi , Barbara Pio , Luc Farmer
发明人： Lin Zhi , Barbara Pio , Luc Farmer
IPC分类号： A61K31/37 , A61K31/4025 , A61K31/404 , A61K31/407 , A61K31/416 , A61K31/4178 , A61K31/428 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/55 , A61P5/26 , A61P5/28 , A61P5/34 , A61P5/36 , A61P7/04 , A61P7/06 , A61P13/08 , A61P15/00 , A61P15/04 , A61P15/08 , A61P15/10 , A61P15/16 , A61P15/18 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00 , C07D209/34 , C07D209/96 , C07D215/22 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/48 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D215/36 , C07D215/38 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
-
公开(公告)号：US08501446B2
公开(公告)日：2013-08-06
申请号：US13441287
申请日：2012-04-06
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： C12N9/99 , C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
公开(公告)号：US20100272681A1
公开(公告)日：2010-10-28
申请号：US12528952
申请日：2008-02-20
申请人： Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Robert B. Perni , John Maxwell , Kevin Cottrell , Summer Halas
发明人： Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Robert B. Perni , John Maxwell , Kevin Cottrell , Summer Halas
IPC分类号： A61K38/21 , C07D487/10 , C07D498/10 , A61K31/40 , A61K31/422 , A61K31/42 , A61K31/427 , A61P31/12 , A61K38/00
CPC分类号： C07D487/10 , C07D498/10
摘要： The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的化合物。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，也可用作抗病毒剂。 本发明还涉及包含这些化合物的组合物，用于离体使用或给予患有HCV感染的患者。 本发明还涉及通过施用包含本发明化合物的组合物来治疗患者HCV感染的方法。
-
公开(公告)号：US20090176763A1
公开(公告)日：2009-07-09
申请号：US12273799
申请日：2008-11-19
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： A61K31/55 , C07D401/14 , A61K31/506 , C07D243/08 , A61K31/551 , C07D403/14 , A61K31/496 , C07D471/02 , A61K31/437 , C07D413/14 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
公开(公告)号：US20070203142A1
公开(公告)日：2007-08-30
申请号：US11654375
申请日：2007-01-17
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： A61K31/53 , A61K31/513 , A61K31/506 , C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
-
公开(公告)号：US20060183761A1
公开(公告)日：2006-08-17
申请号：US11346048
申请日：2006-02-01
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
-
7.发明授权Non-steroid progesterone receptor agonist and antagonist and compounds and methods 失效非类固醇孕酮受体激动剂和拮抗剂及其化合物及方法
公开(公告)号：US5808139A
公开(公告)日：1998-09-15
申请号：US303138
申请日：1994-09-08
申请人： I. Charles Pathirana , Christina S. Berger , Robert B. Stein , William Fenical , Todd K. Jones , Lawrence G. Hamann , Michael G. Johnson , Luc Farmer
发明人： I. Charles Pathirana , Christina S. Berger , Robert B. Stein , William Fenical , Todd K. Jones , Lawrence G. Hamann , Michael G. Johnson , Luc Farmer
CPC分类号： C07C69/96
摘要： Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
摘要翻译： 公开了对于孕酮受体是高亲和性，高特异性配体的非甾体化合物。 这些化合物包括作为孕酮受体拮抗剂起作用的环胞膜及其非对映异构体的光谱和色谱纯的（3R） - 环戊砜单甲醚的合成衍生物，以及用作孕酮受体的光谱和色谱纯的（3S） - 环戊砜单甲醚 激动剂。 还公开了使用所公开的化合物调节由孕酮受体介导的过程和用于治疗需要孕酮受体激动剂或拮抗剂治疗的患者的方法。
-
公开(公告)号：US08686143B2
公开(公告)日：2014-04-01
申请号：US13280670
申请日：2011-10-25
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
-
公开(公告)号：US08188281B2
公开(公告)日：2012-05-29
申请号：US12273799
申请日：2008-11-19
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号：US20110136789A1
公开(公告)日：2011-06-09
申请号：US12751016
申请日：2010-03-31
申请人： David Lauffer , Pan Li , Nathan Waal , Kira Mcginty , Qing Tang , Steven Ronkin , Luc Farmer , Dean Shannon , Dylan Jacobs
发明人： David Lauffer , Pan Li , Nathan Waal , Kira Mcginty , Qing Tang , Steven Ronkin , Luc Farmer , Dean Shannon , Dylan Jacobs
IPC分类号： A61K31/55 , C07D401/04 , A61K31/4439 , C07D401/14 , A61K31/4545 , A61P9/00 , A61P37/08 , A61P19/00 , A61P1/16 , A61P31/12 , A61P7/00 , A61P3/10 , A61P35/00 , C12N9/99
CPC分类号： C07D401/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.
摘要翻译： 本发明涉及可用于抑制c-Met蛋白激酶的式I化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。
-
-
-
-
-
-
-
-
-
搜索结果
45 条记录 (耗时 0.047 秒)
