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公开(公告)号：US20140302076A1
公开(公告)日：2014-10-09
申请号：US14237698
申请日：2012-08-13
IPC分类号： C07K14/005 , C07K14/315
CPC分类号： C07K14/315 , A61K9/1075 , A61K9/5184 , A61K39/09 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/523 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/62 , C12N2710/22022 , C12N2710/22043 , C12N2760/16134 , C12N2760/18234 , Y02A50/467
摘要： The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunise an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.
摘要翻译： 本发明提供了涉及病毒壳聚糖的组合物，其包含用于药物组合物的外源免疫原性序列和生产此类组合物的方法，以及相关的分离或纯化的蛋白质和核酸分子，载体，宿主细胞，组合物和增加使用的方法 免疫应答，免疫动物并预防或治疗治疗疾病，病症或病症。 病毒性胶质瘤可以衍生自多瘤病毒，并且包含感兴趣的免疫原在N末端以及进一步在所述辣椒疫苗的C末端和/或一个或多个暴露的环上。
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公开(公告)号：US08512711B2
公开(公告)日：2013-08-20
申请号：US12444092
申请日：2007-10-04
IPC分类号： A61K39/12 , A61K39/145 , A61K39/295 , C12Q1/70
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2760/16122 , C12N2760/16134 , Y02A50/467
摘要： An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus.
摘要翻译： 提供了包含VP1氨基酸序列的分离的蛋白质，其中所述VP1内的一个或多个暴露的环从除了VP1以外的病毒蛋白插入氨基酸序列，并编码核酸。 通常，除VP1以外的病毒蛋白质来自流感病毒，特别是禽流感病毒。 分离的蛋白质可以具有来自单一蛋白质或多种蛋白质的氨基酸序列的插入。 还提供了可用于预防和/或治疗任何病毒来源疾病，特别是流感病毒的表达构建体，VLP，药物组合物，疫苗和治疗方法。
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公开(公告)号：US09580481B2
公开(公告)日：2017-02-28
申请号：US14237698
申请日：2012-08-13
IPC分类号： C07K14/315 , A61K39/09 , A61K39/145 , A61K39/155 , A61K39/21 , C12N15/62 , A61K9/107 , A61K9/51 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： C07K14/315 , A61K9/1075 , A61K9/5184 , A61K39/09 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/523 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/62 , C12N2710/22022 , C12N2710/22043 , C12N2760/16134 , C12N2760/18234 , Y02A50/467
摘要： The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunize an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.
摘要翻译： 本发明提供了涉及病毒壳聚糖的组合物，其包含用于药物组合物的外源免疫原性序列和生产此类组合物的方法，以及相关的分离或纯化的蛋白质和核酸分子，载体，宿主细胞，组合物和增加使用的方法 免疫应答，免疫动物并预防或治疗治疗疾病，病症或病症。 病毒性胶质瘤可以衍生自多瘤病毒，并且包含感兴趣的免疫原在N末端以及进一步在所述辣椒疫苗的C末端和/或一个或多个暴露的环上。
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公开(公告)号：US20100028375A1
公开(公告)日：2010-02-04
申请号：US12444092
申请日：2007-10-04
IPC分类号： A61K39/12 , C07K7/06 , C07K7/08 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/10 , C07H1/00 , C12P21/02 , A61K38/08
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2760/16122 , C12N2760/16134 , Y02A50/467
摘要： An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus.
摘要翻译： 提供了包含VP1氨基酸序列的分离的蛋白质，其中所述VP1内的一个或多个暴露的环从除了VP1以外的病毒蛋白插入氨基酸序列，并编码核酸。 通常，除VP1以外的病毒蛋白质来自流感病毒，特别是禽流感病毒。 分离的蛋白质可以具有来自单一蛋白质或多种蛋白质的氨基酸序列的插入。 还提供了可用于预防和/或治疗任何病毒来源疾病，特别是流感病毒的表达构建体，VLP，药物组合物，疫苗和治疗方法。
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