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公开(公告)号：US08603541B2
公开(公告)日：2013-12-10
申请号：US13331309
申请日：2011-12-20
申请人： Lior Weissman , Nina Raver-Shapira , Israel Nur , Oleg Belyaev
发明人： Lior Weissman , Nina Raver-Shapira , Israel Nur , Oleg Belyaev
IPC分类号： A61K38/01
CPC分类号： A61K35/19 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866
摘要： The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors.Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
摘要翻译： 本发明涉及一种病毒安全的血小板提取物，其制备和用途。 提取物包含生物活性血小板衍生因子的混合物。 有利地，提取物包括所述因素的平衡比例，并且是不可覆盖的。
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公开(公告)号：US20120156306A1
公开(公告)日：2012-06-21
申请号：US13331309
申请日：2011-12-20
申请人： Lior Weissman , Nina Raver-Shapira , Israel Nur , Oleg Belyaev
发明人： Lior Weissman , Nina Raver-Shapira , Israel Nur , Oleg Belyaev
CPC分类号： A61K35/19 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866
摘要： The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors.Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
摘要翻译： 本发明涉及一种病毒安全的血小板提取物，其制备和用途。 提取物包含生物活性血小板衍生因子的混合物。 有利地，提取物包括所述因素的平衡比例，并且是不可覆盖的。
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公开(公告)号：US09328338B2
公开(公告)日：2016-05-03
申请号：US13532997
申请日：2012-06-26
申请人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
发明人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译： 本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。 该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。
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公开(公告)号：US20130005947A1
公开(公告)日：2013-01-03
申请号：US13532997
申请日：2012-06-26
申请人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
发明人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译： 本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。 该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。
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5.发明申请公开(公告)号：US20120294847A1
公开(公告)日：2012-11-22
申请号：US13470788
申请日：2012-05-14
申请人： Roni MINTZ , Oleg Belyaev , Israel Nur , Liliana Bar , Roberto Meildler
发明人： Roni MINTZ , Oleg Belyaev , Israel Nur , Liliana Bar , Roberto Meildler
IPC分类号： A61K39/395 , A61P29/00 , A61P31/00 , C07K16/00
CPC分类号： C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
摘要： The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
摘要翻译： 本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。 一种方法包括在高于3.8至等于或低于5.3的pH范围内使含免疫球蛋白的溶液进行负阳离子交换层析。 该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。
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6.发明申请公开(公告)号：US20100076464A1
公开(公告)日：2010-03-25
申请号：US12563667
申请日：2009-09-21
申请人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
发明人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
CPC分类号： A61L31/143 , A61L31/10 , C08L89/00
摘要： The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
摘要翻译： 本发明涉及一种用于修复软组织中的开口或缺陷的假体，其制备和使用。 本发明的假体包括内部涂覆有稳定的和非完全干燥的纤维蛋白的底物。 假体显示器在植入后减少了术后并发症。
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公开(公告)号：US09023994B2
公开(公告)日：2015-05-05
申请号：US13470788
申请日：2012-05-14
申请人： Roni Mintz , Oleg Belyaev , Israel Nur , Liliana Bar , Roberto Meidler
发明人： Roni Mintz , Oleg Belyaev , Israel Nur , Liliana Bar , Roberto Meidler
CPC分类号： C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
摘要： The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
摘要翻译： 本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。 一种方法包括在高于3.8至等于或低于5.3的pH范围内使含免疫球蛋白的溶液进行负阳离子交换层析。 该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。
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公开(公告)号：US10039865B2
公开(公告)日：2018-08-07
申请号：US12563667
申请日：2009-09-21
申请人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
发明人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
摘要： The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
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9.发明授权公开(公告)号：US08981058B2
公开(公告)日：2015-03-17
申请号：US13847898
申请日：2013-03-20
申请人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
发明人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
摘要翻译： 本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中 足够量的液体即使在干燥后也保持海绵的柔韧性。 然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。
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10.发明授权公开(公告)号：US08968724B2
公开(公告)日：2015-03-03
申请号：US12675234
申请日：2008-08-29
申请人： Edna Bechor , Liliana Bar , Israel Nur
发明人： Edna Bechor , Liliana Bar , Israel Nur
CPC分类号： A61K35/16 , A61K35/545 , A61K38/1709 , A61K38/363 , A61L27/3616 , A61L27/3804 , A61L27/3856 , A61L27/3878 , A61L2430/38 , C12N5/0655 , C12N2500/84 , A61K2300/00
摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration.
摘要翻译： 本发明涉及包含适当的纤连蛋白/纤维蛋白原比例的病毒灭活血浆冷沉淀物浓缩物（VIPCC）用于治疗脊椎疾病，病症或病症如椎间盘退变的用途。
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