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    Method for treating symptoms of a neurodegenerative condition
    3.
    发明授权
    Method for treating symptoms of a neurodegenerative condition 失效
    治疗神经退行性疾病症状的方法

    公开(公告)号：US5756511A

    公开(公告)日：1998-05-26

    申请号：US416270

    申请日：1995-04-03

    申请人： James W. West ,  David W. Leung ,  J. Peter Klein ,  Gail E. Underiner ,  Anil M. Kumar

    发明人： James W. West ,  David W. Leung ,  J. Peter Klein ,  Gail E. Underiner ,  Anil M. Kumar

    IPC分类号： A61K31/522 ,  A01N43/90

    CPC分类号： A61K31/522

    摘要： A method for treating symptoms of Alzheimer's Disease by administering an effective amount of a compound, racemate, isolated R or S enantionmer, solvate, hydrate or salt having the formula: X--terminal heterocyclic moiety. In the above formula, the terminal heterocyclic moiety is a 3,7-dimethylxanthinyl, 3-methylxanthinyyl or xanthinyl moiety and X is: ##STR1## n is zero or an integer from one to four; and m is an integer from seven to fourteen. For compounds useful in the inventive method, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. w may be an integer from one to twenty and R.sub.5 is preferably an hydroxyl, halo C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. R.sub.3 in compounds useful in the inventive method may be either an hydroxyl group, an oxygen atom, the single bond represented being instead a double bond, or --O--R.sub.4, R.sub.4 being a C.sub.1-6 oxoalkyl.

    摘要翻译： 通过施用有效量的具有下式的化合物，外消旋物，分离的R或S对映体，溶剂合物，水合物或盐，来治疗阿尔茨海默病症状的方法：在上式中，末端杂环部分为 3,7-二甲基黄烷基，3-甲基黄嘌呤基或xanthinyl部分，X为：n为0或1至4的整数; m为7〜14的整数。 对于可用于本发明方法的化合物，R 1和R 2是氢，直链或支链烷基，链烯基或炔基，其长度为至多20个碳原子或 - （CH 2）w R 5。 w可以是从一到二十的整数，R 5优选为羟基，卤代C 1-8烷氧基或取代或未取代的碳环或杂环。 可用于本发明方法的化合物中的R 3可以是羟基，氧原子，所表示的单键代替双键，或-O-R4，R4是C1-6氧代烷基。

    Amine substituted xanthinyl compounds
    4.
    发明授权
    Amine substituted xanthinyl compounds 失效
    胺取代的黄原胶化合物

    公开(公告)号：US5807861A

    公开(公告)日：1998-09-15

    申请号：US476911

    申请日：1995-06-07

    申请人： J. Peter Klein ,  Gail E. Underiner ,  Anil M. Kumar ,  Lance H. Ridgers ,  Glenn C. Rice ,  David W. Leung

    发明人： J. Peter Klein ,  Gail E. Underiner ,  Anil M. Kumar ,  Lance H. Ridgers ,  Glenn C. Rice ,  David W. Leung

    IPC分类号： C07D239/54 ,  C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D513/04 ,  A61K31/52

    CPC分类号： C07D239/54 ,  C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D513/04

    摘要： A method for treating a disease caused by an undesirable cell response mediated by a proliferative intracellular signaling pathway is provided wherein an effective amount of a compound is administered. The compound, resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof, has the formula CORE MOIETY--(R).sub.j wherein j is an integer from one to three; the core moiety is xanthinyl; and R is independently selected from the group consisting of amine, hydrogen, halogen, hydroxyl, C.sub.(1-10) alkyl, C.sub.(2-10) alkenyl, 2-bromopropyl, 4-chloropentyl, cyclohexyl, cyclopentyl, 3-dimethylaminobutyl, 2-hydroxyethyl, 5-hydroxyhexyl, 3-hydroxy-n-butyl, 3-hydroxypropyl, 2-methoxyethyl, 4-methoxy-n-butyl, phenyl, and formula I, at least one R comprising formula I ##STR1## wherein (CH.sub.2).sub.n is optionally substituted; n is an integer from five to twenty; each R.sub.1 or R.sub.2 is independently hydrogen or an optionally substituted group that is herein defined; and wherein, when the (CH.sub.2).sub.n, R.sub.1 or R.sub.2 is substituted, a substituent is selected from the group consisting of carbamoyl, primary, secondary and tertiary amino, C.sub.(2-8) alkenyl, C.sub.(1-8) alkyl, C.sub.(1-8) alkoxyl, C.sub.(1-8) hydroxyalkyl, azido, carbonato, carbonyl, carboxyl, cyano, C.sub.(1-8) haloalkyl, isocyano, isomercaptocyano, phospho, phosphonato, sulfonato, alkylsulfonyl, alkylsulfoxidyl, mercaptocarbonyl, mercaptocarbonato, thioureido and ureido.

    摘要翻译： 提供了治疗由增殖性细胞内信号传导途径介导的不良细胞应答引起的疾病的方法，其中施用有效量的化合物。 化合物，拆分的对映体，非对映异构体，水合物，盐，溶剂合物及其混合物具有式CORE MOIETY-（R）j，其中j是1至3的整数; 核心部分是xanthinyl; 并且R独立地选自胺，氢，卤素，羟基，C（1-10）烷基，C（2-10）烯基，2-溴丙基，4-氯戊基，环己基，环戊基，3-二甲基氨基丁基， 2-羟基乙基，5-羟基己基，3-羟基 - 正丁基，3-羟基丙基，2-甲氧基乙基，4-甲氧基 - 正丁基，苯基和式I，至少一个R包括式I其中 （CH 2）n任选被取代; n是从5到20的整数; 每个R 1或R 2独立地为氢或本文定义的任选取代的基团; 并且其中当（CH 2）n，R 1或R 2被取代时，取代基选自氨基甲酰基，伯，仲和叔氨基，C（2-8）烯基，C（1-8）烷基， C（1-8）烷氧基，C（1-8）羟基烷基，叠氮基，碳酸根，羰基，羧基，氰基，C（1-8）卤代烷基，异氰基，异构体巯基，磷酸根，膦酸根，磺酸根，烷基磺酰基，烷基亚砜基，巯基羰基， 巯基羰基，硫脲基和脲基。

    Method and system for designing an impingement film floatwall panel system
    8.
    发明授权
    Method and system for designing an impingement film floatwall panel system 有权
    冲击膜浮法面板系统设计方法及系统

    公开(公告)号：US06973419B1

    公开(公告)日：2005-12-06

    申请号：US09517567

    申请日：2000-03-02

    申请人： Thomas B. Fortin ,  Gregory E. Chetta ,  David W. Leung ,  Duncan C. Meyers ,  Keith C. Belson ,  John V. Diaz ,  Thomas E. Holladay ,  Scott A. Ladd ,  Randall G. McKinney ,  Sergio Rinella ,  Andreas Sadil ,  George F. Titterton, III

    发明人： Thomas B. Fortin ,  Gregory E. Chetta ,  David W. Leung ,  Duncan C. Meyers ,  Keith C. Belson ,  John V. Diaz ,  Thomas E. Holladay ,  Scott A. Ladd ,  Randall G. McKinney ,  Sergio Rinella ,  Andreas Sadil ,  George F. Titterton, III

    IPC分类号： F23R3/00 ,  G06G7/48

    CPC分类号： F23R3/002 ,  F23R2900/00018 ,  F23R2900/03044 ,  Y02T50/675 ,  Y10T477/40

    摘要： A method and system for designing an impingement film floatwall panel system for a combustion chamber for a gas turbine engine comprising the steps of creating an impingement film floatwall panel knowledge base of information. The knowledge base has a plurality of design rule signals with respect to a corresponding plurality of parameter signals of associated elements of impingement film floatwall panels for a combustion chamber, wherein the knowledge base comprises at least one data value signal for each one of the plurality of design rule signals. The steps also include entering a desired data value signal for a selected one of the plurality of parameter signals of an associated element of the impingement film floatwall panels and comparing the entered desired data value signal for the selected one of the plurality of parameters with the corresponding at least one data value signal in the knowledge base for the corresponding one of the plurality of design rule signals. If the result of the step of comparing is such that the entered desired data value signal for the selected one of the plurality of parameter signals is determined to have a first predetermined relationship with respect to the corresponding at least one data value signal in the knowledge base for the selected one of the plurality of design rule signals, create signals representative of a geometric representation of the selected one of the plurality of parameter signals of the associated element of the impingement film floatwall panels.

    摘要翻译： 一种用于设计用于燃气涡轮发动机的燃烧室的冲击膜浮动面板系统的方法和系统，包括以下步骤：创建冲击膜浮体墙板信息的知识库。 知识库相对于燃烧室的冲击膜浮动面板的相关元件的相应多个参数信号具有多个设计规则信号，其中知识库包括至少一个数据值信号，用于多个 设计规则信号。 这些步骤还包括为冲击薄膜浮动面板的相关元件的多个参数信号中选定的一个参数信号输入期望的数据值信号，并将输入的多个参数中所选择的一个参数的期望数据值信号与相应的 所述知识库中的所述多个设计规则信号中的相应一个的至少一个数据值信号。 如果比较步骤的结果是使得所输入的多个参数信号中所选择的一个参数信号的期望数据值信号被确定为相对于知识库中相应的至少一个数据值信号具有第一预定关系 对于所选择的多个设计规则信号中的一个，创建表示冲击膜浮体面板的相关元件的多个参数信号中所选择的一个的几何表示的信号。