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    Lectin-derived progenitor cell preservation factors and methods of use
    1.
    发明申请
    Lectin-derived progenitor cell preservation factors and methods of use 审中-公开
    凝集素衍生的祖细胞保存因子及使用方法

    公开(公告)号：US20050060779A1

    公开(公告)日：2005-03-17

    申请号：US10929743

    申请日：2004-08-30

    申请人： M. Colucci ,  Maarten Chrispeels ,  Jeffrey Moore

    发明人： M. Colucci ,  Maarten Chrispeels ,  Jeffrey Moore

    IPC分类号： C12N15/09 ,  A61K35/12 ,  C07K14/42 ,  C12N5/0789 ,  C12N5/10 ,  C12N15/90 ,  A01H5/00 ,  C07H21/04 ,  C12N9/24 ,  C12N5/04

    CPC分类号： C12N15/90 ,  A61K38/00 ,  A61K2035/124 ,  C07K14/42 ,  C12N5/0647 ,  C12N2501/26 ,  C12N2501/59

    摘要： The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

    摘要翻译： 本发明涉及分离的核酸分子，其编码有效保留祖细胞的蛋白质，例如造血祖细胞。 核酸包含由SEQ ID NO：1定义的序列，其同系物或其片段。 编码的蛋白质具有包含由SEQ ID NO：2定义的序列的氨基酸序列，其含有氨基酸序列TNNVLQVT的同源物或其片段。 还描述了使用编码的蛋白质在体外，离体和体内保存祖细胞的方法。 因此，本发明包括诸如用于癌症治疗的骨髓消融治疗的方法，其中通过指定的蛋白质促进骨髓重建。 通过本发明也可实现其它治疗用途，例如，离体扩增祖细胞群以增加移植的机会，改善运输和储存祖细胞的条件，以及促进基因治疗以治疗和治愈广泛的危及生命的血液学 疾病

    Lectin-derived progenitor cell preservation factors and methods of use
    2.
    发明申请
    Lectin-derived progenitor cell preservation factors and methods of use 审中-公开
    凝集素衍生的祖细胞保存因子及使用方法

    公开(公告)号：US20070280904A1

    公开(公告)日：2007-12-06

    申请号：US11715811

    申请日：2007-03-08

    申请人： M. Colucci ,  Maarten Chrispeels ,  Jeffrey Moore

    发明人： M. Colucci ,  Maarten Chrispeels ,  Jeffrey Moore

    IPC分类号： A61K38/20 ,  A61K35/12 ,  C07H21/00 ,  C12N5/00 ,  A61K38/16

    CPC分类号： C12N15/90 ,  A61K38/00 ,  A61K2035/124 ,  C07K14/42 ,  C12N5/0647 ,  C12N2501/26 ,  C12N2501/59

    摘要： The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof, or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

    摘要翻译： 本发明涉及分离的核酸分子，其编码有效保留祖细胞的蛋白质，例如造血祖细胞。 核酸包含由SEQ ID NO：1定义的序列，其同系物或其片段。 编码的蛋白质具有包含SEQ ID NO：2定义的序列的氨基酸序列，其同源物或其含有氨基酸序列TNNVLQVT的片段。 还描述了使用编码的蛋白质在体外，离体和体内保存祖细胞的方法。 因此，本发明包括诸如用于癌症治疗的骨髓消融治疗的方法，其中通过指定的蛋白质促进骨髓重建。 通过本发明也可实现其它治疗用途，例如，离体扩增祖细胞群以增加移植的机会，改善运输和储存祖细胞的条件，以及促进基因治疗以治疗和治愈广泛的危及生命的血液学 疾病

    SECRETED FXYD PROTEINS EXPRESSED IN RESPONSE TO EPITHELIAL TISSUE DAMAGE, AND USES THEREFOR
    6.
    发明申请
    SECRETED FXYD PROTEINS EXPRESSED IN RESPONSE TO EPITHELIAL TISSUE DAMAGE, AND USES THEREFOR 审中-公开
    分泌的FXYD蛋白质对上皮组织损伤的反应及其用途

    公开(公告)号：US20120183562A1

    公开(公告)日：2012-07-19

    申请号：US13203193

    申请日：2010-02-24

    申请人： Gerard Brady ,  Shaun Ainsworth ,  Patricia Hurley ,  Christopher Potten ,  Jeffrey Moore

    发明人： Gerard Brady ,  Shaun Ainsworth ,  Patricia Hurley ,  Christopher Potten ,  Jeffrey Moore

    IPC分类号： A61K39/395 ,  C07K17/00 ,  C07K14/435 ,  G01N33/53 ,  A61K39/00 ,  C07H21/04 ,  A61P17/00 ,  C07K16/28 ,  A61K38/17

    CPC分类号： G01N33/6893

    摘要： Secreted FXYD family proteins are expressed by intestinal mucosa and/or associated tissues to regulate cell production in intestinal crypts in response to tissue damage. Such tissue damage may arise from disease, exposure to injurious chemicals (e.g., due to poisoning, chemotherapy, chemical weapons), or exposure to injurious radiation (e.g., due to nuclear power accidents, radiological weapons, radiation therapy). Because these proteins are secreted in response to epithelial tissue damage, some of them are implicated in tissue repair response or an inflammatory response which prolongs or exacerbates the tissue damage. Examples of these proteins include FXYD 3, FXYD 4, and FXYD 5. Diagnostic methods based upon the role of the FXYD proteins in epithelial tissue damage are disclosed. Also provided are antibodies raised against the FXYD family proteins, a kit for detecting at least an epitope of a polypeptide, a method of producing an antibody raised against an epitope of a polypeptide, and a method of diagnosing damage to an epithelial tissue.

    摘要翻译： 分泌的FXYD家族蛋白质由肠粘膜和/或相关组织表达，以调节肠道隐窝中的细胞产生以响应组织损伤。 这种组织损伤可能由疾病，暴露于有害化学物质（例如由于中毒，化疗，化学武器）或暴露于有害辐射（例如由于核电事故，放射性武器，放射治疗）而产生。 因为这些蛋白质是响应于上皮组织损伤而分泌的，其中一些蛋白质涉及组织修复反应或延长或加剧组织损伤的炎症反应。 这些蛋白质的实例包括FXYD 3，FXYD 4和FXYD 5.基于FXYD蛋白在上皮组织损伤中的作用的诊断方法被公开。 还提供了针对FXYD家族蛋白产生的抗体，用于检测多肽的至少一个表位的试剂盒，产生针对多肽的表位产生的抗体的方法，以及诊断对上皮组织的损伤的方法。

    Flourescent organic nanofibrils as sensory materials for explosives detection
    7.
    发明申请
    Flourescent organic nanofibrils as sensory materials for explosives detection 有权
    荧光有机纳米纤维作为爆炸物检测的感觉材料

    公开(公告)号：US20090233374A1

    公开(公告)日：2009-09-17

    申请号：US12110869

    申请日：2008-04-28

    申请人： Ling Zang ,  Jeffrey Moore ,  Tammene Naddo ,  Wei Zhang

    发明人： Ling Zang ,  Jeffrey Moore ,  Tammene Naddo ,  Wei Zhang

    IPC分类号： G01N33/00 ,  B29C39/00 ,  G01N21/75

    CPC分类号： G01N33/0047 ,  G01N21/6428 ,  G01N27/4141 ,  G01N33/0057 ,  Y10T436/17

    摘要： The present invention relates to a class of fluorescent, organic nanofibrils, and particularly the films comprising entangled piling of these nanofibrils exhibiting effective quenching of their fluorescence upon exposure the vapor of explosives. The invention also relates to a sensor and a method for sensing the explosives vapor and other volatile organic compounds, including the explosives taggants through the modulation of the fluorescence of the nanofibril film and the electrical conductivity of the nanofibrils. The invention also relates to a development of synthetic methods, protocols and techniques that leads to production of various arylene-ethynylene macrocycle (AEM) molecules, which consist of a shape-persistent, toroidal scaffold in planar conformation, with minimal ring strain and highly tunable ring sizes (from 0.5 nm to above 10 nm). The invention also relates to an approach to optimization of the one-dimensional molecular arrangement along the long axis of the nanofibril, which provides increased exciton (excited state) migration (via cofacial intermolecular electronic coupling) and charge transport (via pi-electronic delocalization). A combination of long-range exciton migration and efficient charge transport makes the nanofibrils ideal as sensory materials for detecting explosives and other volatile organic compounds through both optical and electrical sensing mechanisms.

    摘要翻译： 本发明涉及一类荧光，有机纳米原纤维，特别是涉及这些纳米纤维缠结的薄膜，这些纳米纤维在暴露爆炸物的蒸气时表现出有效的淬灭荧光。 本发明还涉及一种用于通过调节纳米纤维膜的荧光和纳米原纤维的电导率来感测爆炸物蒸汽和其它挥发性有机化合物（包括爆炸物标记物）的传感器和方法。 本发明还涉及导致生产各种亚芳基 - 亚乙炔大环（AEM）分子的合成方法，方案和技术的开发，所述亚芳基 - 亚乙炔大环（AEM）分子由平面构象中的形状持久的环形支架构成，具有最小的环应变和高度可调的 环尺寸（从0.5nm到10nm以上）。 本发明还涉及一种优化沿着纳米纤丝长轴的一维分子排列的方法，该方法提供增加的激子（激发态）迁移（通过共面分子间电子耦合）和电荷传输（通过π电子离域） 。 长距离激子迁移和高效电荷传输的组合使得纳米原纤维理想成为用于通过光学和电学感测机制检测爆炸物和其它挥发性有机化合物的感觉材料。

    Battery box assembly
    8.
    发明申请
    Battery box assembly 失效

    公开(公告)号：US20060201558A1

    公开(公告)日：2006-09-14

    申请号：US11324901

    申请日：2006-01-04

    申请人： Garry Marty ,  Timothy Sailors ,  Jeffrey Moore

    发明人： Garry Marty ,  Timothy Sailors ,  Jeffrey Moore

    IPC分类号： G05D16/06

    CPC分类号： H01M2/1022 ,  E03C1/055 ,  H01M2/105 ,  H01M2/1055 ,  Y10T137/87917

    摘要： A battery compartment assembly includes a housing and a lid configured to be removably attached to the housing. The lid includes a pair of hinges that engage a corresponding pair of openings in the housing, and a latch that engages a ridge on the housing when the lid is in the closed position. The lid also includes a pair of contacts that extend from the lid to mate with connectors of a control unit to be powered by the batteries in the assembly. A spring is included in the housing for connecting to a positive terminal of a first battery and a negative terminal of a second battery.

    Method and system for automated control of audio and video sources and a final composite output thereof through a video switcher
    9.
    发明申请
    Method and system for automated control of audio and video sources and a final composite output thereof through a video switcher 有权
    通过视频切换器自动控制音频和视频源的方法和系统及其最终的复合输出

    公开(公告)号：US20050223106A1

    公开(公告)日：2005-10-06

    申请号：US11087629

    申请日：2005-03-24

    申请人： David Ross ,  Jeffrey Moore ,  Troy English ,  Gerald Kuch ,  Charles Pepper ,  Christopher Rude ,  Jonathan Pile ,  Alun Fryer

    发明人： David Ross ,  Jeffrey Moore ,  Troy English ,  Gerald Kuch ,  Charles Pepper ,  Christopher Rude ,  Jonathan Pile ,  Alun Fryer

    IPC分类号： G06F15/16 ,  G11B27/034 ,  G11B27/036 ,  H04N7/173

    CPC分类号： G11B27/034 ,  G11B27/036

    摘要： An audio and video production system and method, including a video production control switcher; and one or more computers connected through a network and configured for controlling the video production control switcher. The system is further configured for at least one of defining looks, including shot templates, that correspond to particular settings on the production control switcher or settings of parts of the production control switcher; defining sequences of the looks or assigning individual looks to control elements on a computer of the computers; transmitting the looks across the network; and translating of a single look into one or more standard editor commands, and transmitting the commands to the production control switcher.

    摘要翻译： 一种影音制作系统及方法，包括视频制作控制切换器; 以及通过网络连接并被配置为用于控制视频制作控制切换器的一个或多个计算机。 所述系统进一步被配置用于对与所述生产控制切换器上的特定设置或生产控制切换器的部件的设置相对应的定义外观，包括镜头模板中的至少一个; 定义外观的序列或分配单独外观以控制计算机的计算机上的元件; 通过网络传输外观; 并且将单个外观转换为一个或多个标准编辑器命令，以及将命令传送到生产控制切换器。

    Current sensor
    10.
    发明申请
    Current sensor 审中-公开
    电流传感器

    公开(公告)号：US20050134253A1

    公开(公告)日：2005-06-23

    申请号：US10813979

    申请日：2004-03-29

    申请人： Thomas Kovanko ,  Michael Ennis ,  Jeffrey Moore ,  Debashis Satpathi

    发明人： Thomas Kovanko ,  Michael Ennis ,  Jeffrey Moore ,  Debashis Satpathi

    IPC分类号： G01R15/20 ,  G01R15/24 ,  G01R31/00

    CPC分类号： G01R15/245

    摘要： A magneto-striction based, passive optical current sensor is provided that is located at high voltage and communicates to ground level via an optical fiber. The optical current sensor includes a ferromagnetic core, a modulator of magnetostrictive material, e.g. Terfenol-D in a preferred embodiment, that responds to the magnetic field, and two or more matched fiber Bragg gratings that convert this response into a wavelength modulated optical signal that is transmitted via an optical fiber to ground level electronics. To linearize the output of the optical current sensor, the optical sensor includes arrangements to provide both mechanical and magnetic bias to the modulator.

    摘要翻译： 提供了一种基于磁致伸缩的无源光电流传感器，其位于高电压处，并通过光纤与地平面通信。 光电流传感器包括铁磁芯，例如磁致伸缩材料的调制器。 在优选实施例中的Terfenol-D，其响应于磁场，以及两个或更多个匹配的光纤布拉格光栅，其将该响应转换成经由光纤传输到地面电平的波长调制的光信号。 为了线性化光电流传感器的输出，光学传感器包括为调制器提供机械和磁偏置两者的布置。