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    Efficient Ion Trapping
    2.
    发明申请
    Efficient Ion Trapping 审中-公开

    公开(公告)号：US20170345637A1

    公开(公告)日：2017-11-30

    申请号：US15603593

    申请日：2017-05-24

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond GREEN ,  Kevin GILES ,  David J. LANGRIDGE

    IPC: H01J49/42

    CPC classification number: H01J49/4225 ,  H01J49/4265

    Abstract: An ion trapping system is disclosed comprising an ion urging system for urging ions to spread out within an ion trapping region. Alternatively, the ion trapping system may deflect ions such that ions enter the ion trapping region at different locations. Alternatively, an ion deflector may be arranged upstream of, or at the entrance to, the ion trapping region, for deflecting ions such that ions enter the ion trapping region with different speeds so that the ions spread out within the ion trapping region.

    Ion Mobility Spectrometry Data Directed Acquisition
    3.
    发明申请
    Ion Mobility Spectrometry Data Directed Acquisition 审中-公开

    公开(公告)号：US20170140908A1

    公开(公告)日：2017-05-18

    申请号：US15317045

    申请日：2015-06-11

    Applicant: Micromass UK Limited

    Inventor： Kevin GILES ,  Martin Raymond GREEN ,  Steven Derek PRINGLE ,  Keith RICHARDSON ,  Jason Lee WILDGOOSE

    IPC: H01J49/00 ,  G01N27/62

    CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0045

    Abstract: A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion species of interest and determining a mode of operation of a mass spectrometer for said target ion species of interest using data relating to said target ion species of interest in said two-dimensional data set, wherein said mode of operation comprises the location of fragmentation of said target ions of interest.

    Accurate Mobility Chromatograms
    4.
    发明申请
    Accurate Mobility Chromatograms 审中-公开

    公开(公告)号：US20170276645A1

    公开(公告)日：2017-09-28

    申请号：US15514029

    申请日：2015-09-25

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond GREEN

    IPC: G01N27/62 ,  G01N30/86 ,  G01N30/72

    CPC classification number: G01N27/622 ,  G01N30/7233 ,  G01N30/8631 ,  H01J49/0036 ,  H01J49/004 ,  H01J49/4215

    Abstract: A method of mass spectrometry is disclosed comprising: a) separating first ions or components of an analyte sample according to a physicochemical property other than ion mobility; b) separating said first ions or second ions formed from said components according to ion mobility; c) detecting the intensities of said first ions, or detecting the intensities of second ions formed from said components, or detecting the intensities of ions derived from said first or second ions; wherein the intensity of the ions detected at any given time is recorded together with an associated value of said physicochemical property and an associated value of said ion mobility so as to obtain spectral data; d) examining the intensities of the spectral data as a function of said ion mobility so as to detect an intensity peak in said spectral data, determining a discrete value of ion mobility for said peak, and defining a window of values of ion mobility that encompasses said discrete value; and e) filtering said spectral data so as to include only spectral data that has been associated with values of ion mobility that are within said window of ion mobility values.

    Multipath Duty Cycle Enhancement
    5.
    发明申请
    Multipath Duty Cycle Enhancement 审中-公开

    公开(公告)号：US20170213713A1

    公开(公告)日：2017-07-27

    申请号：US15315185

    申请日：2015-06-05

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond GREEN ,  David J. LANGRIDGE ,  Keith RICHARDSON ,  Jason Lee WILDGOOSE

    IPC: H01J49/00 ,  G01N27/62 ,  H01J49/06

    CPC classification number: H01J49/0045 ,  G01N27/624 ,  H01J49/0031 ,  H01J49/06

    Abstract: A mass spectrometer is disclosed comprising a first device, a second device and a switch arranged and adapted: (i) to direct ions at a first time T1 to the first device and to substantially prevent ions from entering the second device; and (ii) to direct ions at a second later time T2 to the second device and to substantially prevent ions from entering the first device. At the first time T1 the second device may not be in an operational state to potentially optimally fragment, react, mass filter or otherwise process ions since the second device may be in a process of equilibration, changing state, re-filling, recharging, transition, replenishing, switching voltage or altering an operational parameter. Likewise, at the second time T2 the first device may not be in an operational state to potentially optimally fragment, react, mass filter or otherwise process ions since the first device may be in a process of equilibration, changing state, re-filling, recharging, transition, replenishing, switching voltage or altering an operational parameter.

    Mobility Selective Attenuation
    6.
    发明申请
    Mobility Selective Attenuation 审中-公开

    公开(公告)号：US20170212081A1

    公开(公告)日：2017-07-27

    申请号：US15315148

    申请日：2015-06-05

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond GREEN ,  Jason Lee WILDGOOSE

    IPC: G01N27/62 ,  H01J49/00

    CPC classification number: G01N27/622 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/004

    Abstract: A method of mass spectrometry is disclosed comprising separating a first population of ions according to their ion mobility and selectively attenuating ions in the first population of ions in one or more ion mobility and/or drift time ranges so as to form a second population of ions. The step of selectively attenuating ions comprises applying a varying, increasing or decreasing attenuation factor to ions in different ion mobility and/or drift time ranges. The method further comprises separating the second population of ions according to their ion mobility.

    Dynamic Post Column Addition
    10.
    发明申请
    Dynamic Post Column Addition 审中-公开

    公开(公告)号：US20170315101A1

    公开(公告)日：2017-11-02

    申请号：US15524835

    申请日：2015-11-05

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond GREEN

    IPC: G01N30/06 ,  G01N30/72

    CPC classification number: G01N30/06 ,  G01N30/7206 ,  G01N30/724 ,  G01N2030/067 ,  G01N2030/8809

    Abstract: A method of ionising a sample is disclosed comprising performing an initial experiment comprising: (i) adding one or more reagents to an analyte sample; (ii) varying the composition and/or concentration of the one or more reagents; (iii) ionising the analyte sample including the one or more reagents; (iv) determining the composition and/or concentration of the one or more reagents which results in a desired, improved or optimised ionisation or other condition or parameter for one or more analytes of interest; and (v) determining one or more first retention times or one or more first retention time windows for the one or more analytes of interest. The method then further comprises separating an analyte sample using a first separation device and during the course of a single experimental run or acquisition varying the composition and/or concentration of one or more reagents which are added to an eluent which emerges from the first separation device. The composition and/or concentration of the one or more reagents which are added to the eluent is varied at the one or more the first retention times or during the one or more the first retention time windows so that an ionisation or other condition or parameter for the one or more analytes of interest is as desired or is improved or optimised.

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