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    Data Directed Acquisition of Imaging Mass
    2.
    发明申请
    Data Directed Acquisition of Imaging Mass 有权
    数据定向采集成像质量

    公开(公告)号：US20160049282A1

    公开(公告)日：2016-02-18

    申请号：US14776175

    申请日：2014-03-14

    Applicant: MICROMASS UK LIMITED

    Inventor： Jeffery Mark BROWN ,  Richard CHAPMAN ,  Paul MURRAY ,  Keith RICHARDSON ,  Emmy Maria HOYES

    IPC: H01J49/00 ,  H01J49/16

    CPC classification number: H01J49/0004 ,  H01J49/164

    Abstract: A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location. A determination is then made as to whether or not the first mass spectral data satisfies a condition, wherein if it is determined that the first mass spectral data does satisfy the condition then the method further comprises: (i) switching to acquire second mass spectral data related to a second pixel location which is substantially adjacent to the first pixel location so that the second mass spectral data is acquired at a second resolution which is higher than the first resolution; and (ii) determining whether or not the second mass spectral data satisfies the condition, wherein if it is determined that the second mass spectral data does satisfy the condition then the method further comprises acquiring third mass spectral data related to a third pixel location which is substantially adjacent to the first or second pixel locations so that the third mass spectral is acquired at the second resolution and wherein if it is determined that the second or third mass spectral data does not satisfy the condition then the method further comprises switching back to scanning the sample at the first resolution.

    Abstract translation: 公开了一种离子成像方法，包括以第一分辨率扫描样品并获取与第一像素位置相关的第一质谱数据。 然后确定第一质谱数据是否满足条件，其中如果确定第一质谱数据确实满足条件，则该方法还包括：（i）切换以获取第二质谱数据 涉及与第一像素位置基本相邻的第二像素位置，使得以高于第一分辨率的第二分辨率获取第二质谱数据; 以及（ii）确定所述第二质谱数据是否满足所述条件，其中如果确定所述第二质谱数据确实满足所述条件，则所述方法还包括获取与第三像素位置有关的第三质谱数据，所述第三质谱数据是 基本上与第一或第二像素位置相邻，使得以第二分辨率获取第三质谱，并且其中如果确定第二或第三质谱数据不满足条件，则该方法还包括切换回扫描 以第一分辨率进行抽样。

    Ion Mobility Spectrometry Data Directed Acquisition
    7.
    发明申请
    Ion Mobility Spectrometry Data Directed Acquisition 审中-公开

    公开(公告)号：US20170140908A1

    公开(公告)日：2017-05-18

    申请号：US15317045

    申请日：2015-06-11

    Applicant: Micromass UK Limited

    Inventor： Kevin GILES ,  Martin Raymond GREEN ,  Steven Derek PRINGLE ,  Keith RICHARDSON ,  Jason Lee WILDGOOSE

    IPC: H01J49/00 ,  G01N27/62

    CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0045

    Abstract: A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion species of interest and determining a mode of operation of a mass spectrometer for said target ion species of interest using data relating to said target ion species of interest in said two-dimensional data set, wherein said mode of operation comprises the location of fragmentation of said target ions of interest.

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