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公开(公告)号：US11304991B2
公开(公告)日：2022-04-19
申请号：US16947808
申请日：2020-08-18
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali , Martin N. Shelton
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US20190337993A1
公开(公告)日：2019-11-07
申请号：US16519963
申请日：2019-07-23
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/005 , A61K39/39 , C07K14/16 , A61K38/16 , G01N33/543 , A61K9/127 , A61K45/06 , G01N33/566 , C12P21/02
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20190337991A1
公开(公告)日：2019-11-07
申请号：US16458218
申请日：2019-07-01
发明人： Vincent C. BOND , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/005 , G01N33/566 , C07K14/16 , A61K45/06 , A61K9/127 , C12P21/02 , A61K38/16 , A61K39/39 , G01N33/543
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20190167759A1
公开(公告)日：2019-06-06
申请号：US16241316
申请日：2019-01-07
发明人： Vincent C. BOND , Michael Powell , Ming Bo Huang , Syed Ali , Martin N. Shelton
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US10206974B2
公开(公告)日：2019-02-19
申请号：US15397359
申请日：2017-01-03
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US20140004181A1
公开(公告)日：2014-01-02
申请号：US14019601
申请日：2013-09-06
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/005 , G01N33/566 , A61K39/39 , A61K45/06 , A61K9/127 , A61K38/16
CPC分类号： C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/00 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
摘要翻译： 本申请涉及生产外来体的方法。 本申请还提供了一种制备蛋白质组合物的方法，包括培养表达融合蛋白质的Nef-融合蛋白的外来体产生细胞，所述Nef-融合蛋白包含与目的蛋白融合的Nef衍生肽; 从外来体产生细胞培养物中分离外来体; 并从分离的外来体纯化目的蛋白质。 本申请还公开了包含含有Nef-融合蛋白的外来体的组合物，以及使用Nef-融合蛋白和含有Nef-融合蛋白的外来体的方法。
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7.发明授权公开(公告)号：US08563506B2
公开(公告)日：2013-10-22
申请号：US13693507
申请日：2012-12-04
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
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公开(公告)号：US20210355172A1
公开(公告)日：2021-11-18
申请号：US17305749
申请日：2021-07-14
发明人： Vincent C. BOND , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , C12P21/02 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/005 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20170209533A1
公开(公告)日：2017-07-27
申请号：US15397359
申请日：2017-01-03
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/49
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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10.发明申请COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 有权通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法公开(公告)号：US20140005117A1
公开(公告)日：2014-01-02
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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