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公开(公告)号：US20220389063A1
公开(公告)日：2022-12-08
申请号：US17806210
申请日：2022-06-09
摘要： The present application relates to methods and compositions and methods for treating viral infections, especially those caused by SARS-CoV-2. In one aspect, a method of treatment comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising a multipartite SARS-CoV-2-inhibiting peptide comprising a secretion modulating region (VI-SMR) peptide from HIV-1 Nef in combination with a cell-penetrating peptide (CPP) domain, a Clusterin (Clu)-binding peptide (Clu-BP) domain, a mitochondrial targeting (Mito-T) peptide domain, an anti-fusogenic (AF) peptide domain, a viral attachment inhibitor (VAI) domain or combination thereof, optionally where the SARS-CoV-2-inhibiting peptide is pegylated and/or modified with one or more hydrophobic domains.
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公开(公告)号：US11472846B2
公开(公告)日：2022-10-18
申请号：US17068061
申请日：2020-10-12
IPC分类号： A61K38/10 , A61K47/64 , C07K14/00 , C07K19/00 , C07K14/005 , A61K47/60 , C12N7/00 , A61K38/16 , A61K45/06 , A61K38/08
摘要： A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
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公开(公告)号：US20210355172A1
公开(公告)日：2021-11-18
申请号：US17305749
申请日：2021-07-14
发明人： Vincent C. BOND , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , C12P21/02 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/005 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US10800817B2
公开(公告)日：2020-10-13
申请号：US16226283
申请日：2018-12-19
IPC分类号： A61K38/08 , A61K35/10 , A61K47/64 , C07K14/005 , A61K47/60 , C12N7/00 , A61K38/16 , A61K45/06 , A61K38/10
摘要： A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
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公开(公告)号：US20170209533A1
公开(公告)日：2017-07-27
申请号：US15397359
申请日：2017-01-03
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/49
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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6.发明申请COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 有权通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法公开(公告)号：US20140005117A1
公开(公告)日：2014-01-02
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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公开(公告)号：US12083159B2
公开(公告)日：2024-09-10
申请号：US16811754
申请日：2020-03-06
IPC分类号： A61K38/16 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/64 , C07K7/06 , C07K14/005 , C12N7/00
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/6455 , C07K7/06 , C07K14/005 , C12N7/00 , C07K2319/10 , C12N2740/16032 , C12N2740/16322 , Y02A50/30
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US12077564B2
公开(公告)日：2024-09-03
申请号：US17305749
申请日：2021-07-14
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , A61K9/127 , A61K38/16 , C07K14/005 , A61K38/00 , A61K39/00 , A61K39/39 , A61K45/06 , C12N15/00 , C12P21/02 , G01N33/543 , G01N33/566
CPC分类号： C07K14/163 , A61K9/127 , A61K38/162 , C07K14/005 , A61K38/00 , A61K39/39 , A61K2039/55555 , A61K45/06 , C07K2319/00 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16311 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US11414462B1
公开(公告)日：2022-08-16
申请号：US17380786
申请日：2021-07-20
摘要： The present application relates to methods and compositions and methods for treating viral infections, especially those caused by SARS-CoV-2. In one aspect, a method of treatment comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising a multipartite SARS-CoV-2-inhibiting peptide comprising a secretion modulating region (VI-SMR) peptide from HIV-1 Nef in combination with a cell-penetrating peptide (CPP) domain, a Clusterin (Clu)-binding peptide (Clu-BP) domain, a mitochondrial targeting (Mito-T) peptide domain, an anti-fusogenic (AF) peptide domain, a viral attachment inhibitor (VAI) domain or combination thereof, optionally where the SARS-CoV-2-inhibiting peptide is pegylated and/or modified with one or more hydrophobic domains.
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公开(公告)号：US20180305412A1
公开(公告)日：2018-10-25
申请号：US16030430
申请日：2018-07-09
IPC分类号： C07K14/005 , C12N7/00 , A61K45/06 , A61K47/64 , A61K38/16
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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