摘要:
The present invention relates to a compound that is useful for treatment of, for example, hypertension, arteriosclerosis, bulimia and obesity because of having an antagonistic action to a neuropeptide Y receptor and is represented by formula (I) [wherein R1 represents hydrogen, cyano, or the like; R represents a group represented by formula (II); X1 represents C1-4 lower alkylene or the like; X2 represents lower alkylene or the like; and Het represents a 5-membered heteroaromatic ring that has at least one nitrogen atom and, in addition, one or two hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms] or to a pharmaceutically acceptable salt thereof.
摘要:
The present invention relates to a compound represented by a formula (I): wherein X is a group represented by or the like; Y is a group represented by or the like; and Ar1 is a group represented by or a pharmaceutically acceptable salt thereof.
摘要:
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]
摘要翻译:公开了由下式(I)表示的芳基取代的含氮杂环化合物或其药学上可接受的盐。 该化合物用作伤害感受肽受体拮抗剂,可用作治疗与伤害感受肽受体相关疾病的药剂。 (I)[式中,A1,A2和A3独立地表示碳原子或氮原子,A1,A2和A3中的一个或二个表示碳原子; R1表示低级烷基等; R 2表示可以被卤素原子等取代的苯基; R3表示氢原子,低级烷基等; R4表示低级烷基等。]
摘要:
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]
摘要翻译:公开了由下式(I)表示的芳基取代的含氮杂环化合物或其药学上可接受的盐。 该化合物用作伤害感受肽受体拮抗剂,可用作治疗与伤害感受肽受体相关疾病的药剂。 (I)[式中,A1,A2和A3独立地表示碳原子或氮原子,A1,A2和A3中的一个或二个表示碳原子; R1表示低级烷基等; R 2表示可以被卤素原子等取代的苯基; R3表示氢原子,低级烷基等; R4表示低级烷基等。]
摘要:
This invention provides compounds which are represented by a general formula [I] [in which X stands for hydrogen or halogen; B stands for halogen, cyano or optionally fluorine-substituted lower alkyl; D stands for a 3–10 membered aliphatic nitrogen-containing heterocyclic group; R3, R4 and R5 may be same or different, and each stands for hydrogen, lower alkyl optionally having substituent group(s) and the like; and a is 0 or 1]. These compounds exhibit high affinity to nociceptin receptors and whereby inhibit actions of nociceptin, and are useful as an analgesic, antiobestic, agent for ameliorating brain function, treating agents for Alzheimer's disease and dementia, and therapeutic agents for schizophrenia, neurodegenerative diseases, depression, diabetes insipidus, polyuria, hypotension and the like.
摘要:
This invention relates to the compounds represented by a general formula [I]: [in which A1 and A2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C3-C20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.
摘要:
A novel element capable of simply controlling an in-plane rotational motion of a core (a rising spot of a magnetization) generated in the center of a ferromagnetic dot made by forming a ferromagnetic material into a nanosized disk shape is provided. In addition, a binary information memory element using a core, including a ferromagnetic dot, made of a disk-shaped ferromagnetic material, with a magnetic structure of a magnetic vortex structure, and a current supplier for supplying an alternating current with a predetermined alternating current in the radial direction of the ferromagnetic dot is provided. In the case where the frequency of the current resonates with the intrinsic frequency of the ferromagnetic dot, it is possible to rotate the core in the plane of the dot. Since the core leaks a magnetic field, a microscopic actuator such as a motor can be obtained by using this element. Furthermore, supplying a current having a density not less than a predetermined value reverses the core. This allows the expression of binary information.
摘要:
A method and apparatus for correcting for deterministic jitter in a sequential sampling timebase. The value of a fine analog delay is held at a substantially constant nominal rate during a duration of a counting of a digital clock. A time difference between a trigger at which a fine analog delay starts measuring time and the occurrence of a digital pulse of a stable clock used to count a coarse delay is measured. An input waveform is sampled at a sample time having a nominal delay time. After sampling, a desired compensation time is provided for the sample of the input waveform in accordance with combinations of three independent variables defining a calibration table. The waveform is reconstructed by shifting a delay time of a sampled value of the input waveform from its nominal delay time in accordance with a value defined by the calibration table.
摘要:
In a sampling gate circuit, a broadband and high-precision sampling gate circuit is realized by further employing first and second equivalent sampling networks which are equal to a sampling operation by a first sampling gate circuit. The first and second equivalent sampling networks compensate for distortions in the signal output by the first sampling gate circuit and allow an input waveform to be reproduced at high precision. The output from the first sampling gate circuit is input to a positive terminal of a differential amplifier. The outputs from the first and second equivalent sampling networks are input into two respective negative inputs of a differential amplifier, to cancel the distortions of the signal output from the first sampling gate circuit and input to the positive terminal of the differential amplifier. This device may find particular application in sampling type oscilloscopes or the like.
摘要:
An X-ray imaging apparatus includes: an X-ray sensor configured to convert an X-ray to an image signal; a battery configured to supply electric power for driving the X-ray sensor; a battery holder configured to detachably hold the battery; a lock mechanism configured to lock the battery in a state in which it is attached to the battery holder; and a lock releasing mechanism configured to release the lock effected by the lock mechanism, wherein the lock releasing mechanism is configured to release the lock by the lock mechanism through at least two operations performed by the operator.