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    Mycoplanecin derivatives and their preparation
    1.
    发明授权
    Mycoplanecin derivatives and their preparation 失效
    髓鞘衍生物及其制备方法

    公开(公告)号：US4370266A

    公开(公告)日：1983-01-25

    申请号：US250709

    申请日：1981-04-03

    申请人： Mamoru Arai ,  Tatsuo Haneishi ,  Mutsuo Nakajima ,  Akio Torikata ,  Ryuzo Enokita

    发明人： Mamoru Arai ,  Tatsuo Haneishi ,  Mutsuo Nakajima ,  Akio Torikata ,  Ryuzo Enokita

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C12P21/04 ,  C07C103/52

    CPC分类号： C12R1/045 ,  C07K7/06 ,  A61K38/00 ,  Y10S930/19 ,  Y10S930/27

    摘要： Mycoplanecin derivatives of formula (I): ##STR1## [wherein: R represents a hydrogen atom, an N-(.alpha.-ketobutyryl)-N-methylvalyl group or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group;R.sup.1 represents a methyl group or an ethyl group; andwhen R.sup.1 represents a methyl group, R.sup.2 represents an isobutyl group and, when R.sup.1 represents an ethyl group, R.sup.2 represents a pentyl group] have antibacterial activity which is particularly pronounced against bacteria of the genus Mycobacterium. The compounds in which R represents and N-(.alpha.-ketobutyryl)-N-methylvalyl group, named Mycoplanecin B (R.sup.1 represents a methyl group) and Mycoplanecin C (R.sup.1 represents an ethyl group), may be prepared by cultivation of a microorganism of the genus Actinoplanes, while the compounds where R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group or a hydrogen atom can be prepared by reducing the corresponding compound where R represents an N-(.alpha.-ketobutyryl)-N-methylvalyl group or by hydrolyzing the corresponding compound where R represents an N-(.alpha.-ketobutyryl)-N-methylvalyl or N-(.alpha.-hydroxybutyryl)-N-methylvalyl group, respectively.

    摘要翻译： 式（I）的肌钙蛋白聚糖衍生物：其中：R表示氢原子，N-（α-酮丁酰基）-N-甲基缬氨酰基或N-（α-羟基丁酰基）-N-甲基缬氨酰基 ; R1表示甲基或乙基; 当R1表示甲基时，R2表示异丁基，当R1表示乙基时，R2表示戊基]具有对分枝杆菌属细菌特别显着的抗菌活性。 其中R表示的化合物和N-（α-酮丁酰基）-N-甲基缬氨酰基，命名为Mycoplanecin B（R1表示甲基）和Mycoplanecin C（R1表示乙基））可以通过培养 其中R代表N-（α-羟基丁酰基）-N-甲基缬氨酰基或氢原子的化合物可以通过还原相应的化合物来制备，其中R代表N-（α-酮丁酰基）-N-甲基缬氨酰基 或通过水解相应的化合物，其中R表示N-（α-酮丁酰基）-N-甲基缬氨酰基或N-（α-羟基丁酰基）-N-甲基缬氨酰基。

    Macrolide antibiotic
    4.
    发明授权
    Macrolide antibiotic 失效
    大环内酯类抗生素

    公开(公告)号：US4374764A

    公开(公告)日：1983-02-22

    申请号：US199238

    申请日：1980-10-21

    申请人： Mamoru Arai ,  Tatsuo Haneishi ,  Mutsuo Nakajima

    发明人： Mamoru Arai ,  Tatsuo Haneishi ,  Mutsuo Nakajima

    IPC分类号： A61K38/00 ,  A61P31/04 ,  A61P31/06 ,  C07K1/02 ,  C07K1/113 ,  C07K7/06 ,  C07K14/195 ,  C07K14/41 ,  C12P21/02 ,  C12R1/045 ,  C07C103/52

    CPC分类号： C12R1/045 ,  C07K7/06 ,  A61K38/00 ,  Y10S930/17 ,  Y10S930/19

    摘要： Macrolide antibiotics are derivatives of the compound Mycoplanecin and have the formula: ##STR1## (in which R represents a hydrogen atom or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group). The compound in which R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group can be prepared by reducing Mycoplanecin and the compound in which R represents a hydrogen atom can be prepared by the hydrolysis of Mycoplanecin or of the compound of formula (I) in which R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group.

    摘要翻译： 大环内酯类抗生素是化合物Mycoplanecin的衍生物，具有下式：其中R表示氢原子或N-（α-羟基丁酰）-N-甲基缬氨酰基）。 其中R表示N-（α-羟基丁酰基）-N-甲基缬氨酰基的化合物可以通过降低Mycoplanecin来制备，其中R表示氢原子的化合物可以通过水解平均支原体或式 I），其中R表示N-（α-羟基丁酰基）-N-甲基缬氨酰基。

    Apparatus for cutting a moving object into a predetermined length
    7.
    发明授权
    Apparatus for cutting a moving object into a predetermined length 失效
    用于将移动物体切割成预定长度的装置

    公开(公告)号：US3958481A

    公开(公告)日：1976-05-25

    申请号：US594650

    申请日：1975-07-10

    申请人： Mamoru Arai

    发明人： Mamoru Arai

    IPC分类号： B26D1/58 ,  B65B61/06 ,  B26D1/56

    CPC分类号： B26D1/585 ,  B65B61/06 ,  Y10T83/4737 ,  Y10T83/4749 ,  Y10T83/4766

    摘要： An apparatus for cutting a moving object into pieces of a fixed length, wherein an upper cutter base disposed at a specified distance from a lower cutter base is installed on the upper portion of rods supported to be vertically movable through vertical holes formed in the lower cutter base which is supported transversely on the frame in a rotatable fashion, said upper and lower cutter bases are respectively equipped with the upper and lower cutters confronting each other, the lower ends of said rods are pivotally connected to eccentric positions on the crank discs which are supported vertically on the frame in a rotatable fashion, and said crank discs are rotated by a driving mechanism.

    摘要翻译： 一种用于将移动物体切割成固定长度的装置，其中设置在距离下切割器底座特定距离处的上刀具底座安装在杆的上部，杆的上部可通过形成在下刀具中的竖直孔垂直移动 底座，其以可旋转的方式横向支撑在框架上，所述上下切割器基座分别配备有彼此面对的上切割器和下切割器，所述杆的下端枢转地连接到曲柄盘上的偏心位置， 以可旋转的方式垂直地支撑在框架上，并且所述曲柄盘由驱动机构旋转。

    Plasmid pSAN 181
    8.
    发明授权
    Plasmid pSAN 181 失效
    质粒pSAN 181

    公开(公告)号：US4517300A

    公开(公告)日：1985-05-14

    申请号：US475245

    申请日：1983-03-14

    申请人： Taichi Manome ,  Toshinori Ohmine ,  Takao Okazaki ,  Mamoru Arai

    发明人： Taichi Manome ,  Toshinori Ohmine ,  Takao Okazaki ,  Mamoru Arai

    IPC分类号： C12N15/09 ,  C07H21/04 ,  C12N15/76 ,  C12P19/34 ,  C12R1/465 ,  C12N1/00 ,  C12N15/00

    CPC分类号： C12N15/76

    摘要： A novel plasmid, named pSAN 181, has a molecular weight of 5.+-.0.2 megadaltons and single cleavage sites for each of the restriction endonucleases BamHI, PstI, XhoI and BglII, the positions of said sites being 0, about 0.85, about 1.15 and about 3.95 megadaltons from the cleavage site of BamHI. The plasmid is extracted from mycelia of microorganisms of the species Streptomyces fulvoviridis, especially the strain Streptomyces fulvoviridis FERM P-6279, and is useful as a vector for genetic engineering.

    摘要翻译： 命名为pSAN 181的新型质粒具有5 +/- 0.2兆道尔顿的分子量和每个限制性内切核酸酶BamHI，PstI，XhoI和BglII的单个切割位点，所述位点的位置为0，约0.85，约1.15 和约3.95兆巴斯从BamHI的切割位点。 该质粒是从链霉菌链霉菌（Streptomyces fulvoviridis）的微生物的菌丝体中提取的，特别是菌丝霉菌菌丝霉F-P-6279菌株，可用作基因工程载体。