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公开(公告)号：US08198456B2
公开(公告)日：2012-06-12
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译： 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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公开(公告)号：US20080176833A1
公开(公告)日：2008-07-24
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： A61K31/55 , C07D213/02 , A61K31/4427 , C07D455/02 , A61K31/4375 , C07D295/00 , A61K31/5377 , A61P35/00 , C07D239/24 , A61K31/506 , C07D221/00 , A61K31/496 , C07D223/02
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译： 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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公开(公告)号：US20150284337A1
公开(公告)日：2015-10-08
申请号：US14122199
申请日：2012-05-21
申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Nietz , Gary Probst
发明人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Nietz , Gary Probst
IPC分类号： C07D237/28 , C07D405/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D417/04 , C07D401/12 , C07D401/04
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式I结构的化合物：（I）或其盐或溶剂合物，其中R1，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US20110212942A1
公开(公告)日：2011-09-01
申请号：US12974401
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/55 , C07D475/00 , C07D471/14 , C07D487/14 , C07D498/14 , A61K31/4985 , A61K31/5383 , A61P35/00 , A61P25/28 , A61P25/16 , A61P35/02 , A61P35/04
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US08541418B2
公开(公告)日：2013-09-24
申请号：US12974622
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/4965 , C07D475/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，E1，E2，R 1，R 2，R 3和R 4在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US08445503B2
公开(公告)日：2013-05-21
申请号：US12974401
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A01N43/54 , A61K31/505 , C07D491/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US20120115848A1
公开(公告)日：2012-05-10
申请号：US13267834
申请日：2011-10-06
申请人： Robert A. Galemmo, JR. , Dean Richard Artis, I , Xiaocong Michael Ye , Danielle L. Aubele , Anh P. Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo, JR. , Dean Richard Artis, I , Xiaocong Michael Ye , Danielle L. Aubele , Anh P. Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/55 , C07D471/22 , C07D487/22 , C07D498/22 , A61K31/519 , A61P35/02 , A61K31/5377 , A61P25/00 , A61P25/16 , A61P25/28 , A61P35/00 , A61P35/04 , C07D487/14 , A61K31/5383
CPC分类号： C07D487/14 , C07D487/22 , C07D498/22
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，U1，U2，U3，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US20110207716A1
公开(公告)日：2011-08-25
申请号：US12974622
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/519 , C07D475/00 , C07D475/12 , A61K31/5377 , A61K31/55 , A61K31/5383 , A61P25/28 , A61P25/16 , A61P35/00 , A61P35/04 , A61P35/02
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，E1，E2，R 1，R 2，R 3和R 4在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US09884828B2
公开(公告)日：2018-02-06
申请号：US14122199
申请日：2012-05-21
申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
发明人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
IPC分类号： A61K31/502 , C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D417/04 , C07D413/10
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
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