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公开(公告)号：US08367670B2
公开(公告)日：2013-02-05
申请号：US12632194
申请日：2009-12-07
申请人： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
发明人： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC分类号： C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/519 , A61P31/12 , A61P35/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US20080176833A1
公开(公告)日：2008-07-24
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： A61K31/55 , C07D213/02 , A61K31/4427 , C07D455/02 , A61K31/4375 , C07D295/00 , A61K31/5377 , A61P35/00 , C07D239/24 , A61K31/506 , C07D221/00 , A61K31/496 , C07D223/02
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译： 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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公开(公告)号：US09102614B2
公开(公告)日：2015-08-11
申请号：US13806067
申请日：2011-07-01
申请人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan Mcfadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan Mcfadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
IPC分类号： C07D295/073 , C07D295/155 , C07D493/04 , C07D311/20 , C07D311/58 , C07D239/34 , C07D239/36 , C07D231/12 , C07D213/64 , C07D213/73 , C07D213/65 , C07D205/04 , C07D215/14 , C07C59/64 , C07D211/48 , C07D215/04 , C07D233/58 , C07D241/12 , C07D309/10 , C07D491/06 , C07C229/34 , C07C233/47 , C07C255/57 , C07C271/22 , C07C311/16 , C07D239/26 , C07D239/42 , C07D487/04
CPC分类号： C07C59/64 , C07C229/34 , C07C233/47 , C07C255/57 , C07C271/22 , C07C311/16 , C07D205/04 , C07D211/48 , C07D213/64 , C07D213/65 , C07D213/73 , C07D215/04 , C07D215/14 , C07D231/12 , C07D233/58 , C07D239/26 , C07D239/34 , C07D239/36 , C07D239/42 , C07D241/12 , C07D295/073 , C07D295/155 , C07D309/10 , C07D311/20 , C07D311/58 , C07D487/04 , C07D491/06 , C07D493/04
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供了包含式I化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物的哺乳动物中的AIDS或ARC症状。
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4.发明申请Indolinone derivatives and their use in treating disease-states such as cancer 失效吲哚酮衍生物及其在治疗疾病状态如癌症中的应用公开(公告)号：US20050090541A1
公开(公告)日：2005-04-28
申请号：US10972023
申请日：2004-10-22
申请人： Damian Arnaiz , Judi Bryant , Yuo-Ling Chou , Richard Feldman , Paul Hrvatin , Imadul Islam , Monica Kochanny , Wheeseong Lee , Mark Polokoff , Hongyi Yu , Shendong Yuan
发明人： Damian Arnaiz , Judi Bryant , Yuo-Ling Chou , Richard Feldman , Paul Hrvatin , Imadul Islam , Monica Kochanny , Wheeseong Lee , Mark Polokoff , Hongyi Yu , Shendong Yuan
IPC分类号： A61K31/405 , C07D209/34 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D407/14 , C07D409/06 , C07D413/14 , C07D43/02
CPC分类号： C07D209/34 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06
摘要： Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
摘要翻译： 吲哚啉酮衍生物，例如式（I）的化合物：其中A，m，n，R 1，R 2，R 3， 本文所述的本文所述的R 5和R 6 6可用于治疗通过抑制PDK-1活性而减轻疾病的哺乳动物。
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5.发明授权Indolinone derivatives and their use in treating disease-states such as cancer 失效吲哚酮衍生物及其在治疗疾病状态如癌症中的应用公开(公告)号：US07105563B2
公开(公告)日：2006-09-12
申请号：US10972023
申请日：2004-10-22
申请人： Damian Arnaiz , Judi Bryant , Yuo-Ling Chou , Richard Feldman , Paul Hrvatin , Imadul Islam , Monica Kochanny , Wheeseong Lee , Mark Polokoff , Hongyi Yu , Shendong Yuan
发明人： Damian Arnaiz , Judi Bryant , Yuo-Ling Chou , Richard Feldman , Paul Hrvatin , Imadul Islam , Monica Kochanny , Wheeseong Lee , Mark Polokoff , Hongyi Yu , Shendong Yuan
IPC分类号： A61K31/404 , C07D209/34
CPC分类号： C07D209/34 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06
摘要： Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
摘要翻译： 吲哚啉酮衍生物，例如式（I）的化合物：其中A，m，n，R 1，R 2，R 3， 本文所述的本文所述的R 5和R 6 6可用于治疗通过抑制PDK-1活性而减轻疾病的哺乳动物。
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公开(公告)号：US20130203727A1
公开(公告)日：2013-08-08
申请号：US13806067
申请日：2011-07-01
申请人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
IPC分类号： C07C59/64 , C07D491/06 , C07D205/04 , C07D239/34 , C07D295/155 , C07C311/16 , C07C255/57 , C07C229/34 , C07D213/65 , C07D239/26 , C07D231/12 , C07D487/04 , C07D211/48 , C07D309/10 , C07D311/58 , C07C233/47 , C07C271/22 , C07D239/42 , C07D239/36 , C07D215/14
CPC分类号： C07C59/64 , C07C229/34 , C07C233/47 , C07C255/57 , C07C271/22 , C07C311/16 , C07D205/04 , C07D211/48 , C07D213/64 , C07D213/65 , C07D213/73 , C07D215/04 , C07D215/14 , C07D231/12 , C07D233/58 , C07D239/26 , C07D239/34 , C07D239/36 , C07D239/42 , C07D241/12 , C07D295/073 , C07D295/155 , C07D309/10 , C07D311/20 , C07D311/58 , C07D487/04 , C07D491/06 , C07D493/04
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供了包含式I化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物的哺乳动物中的AIDS或ARC症状。
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公开(公告)号：US08198456B2
公开(公告)日：2012-06-12
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译： 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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公开(公告)号：US20100143301A1
公开(公告)日：2010-06-10
申请号：US12632194
申请日：2009-12-07
申请人： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan Mc Fadden , Paul A. Roethle , Hong Yang
发明人： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan Mc Fadden , Paul A. Roethle , Hong Yang
IPC分类号： A61K31/519 , C07D475/06 , C07D487/04 , A61K31/5377 , A61K31/551 , A61K38/21 , A61K31/7056 , A61K31/675 , A61K31/56 , A61P31/12
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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