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    Adipose-derived stem cells and lattices
    1.
    发明授权
    Adipose-derived stem cells and lattices 有权
    脂肪来源的干细胞和晶格

    公开(公告)号：US07470537B2

    公开(公告)日：2008-12-30

    申请号：US10740315

    申请日：2003-12-17

    申请人： Marc H. Hedrick ,  Adam J. Katz ,  Ramón Llull ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

    发明人： Marc H. Hedrick ,  Adam J. Katz ,  Ramón Llull ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90

    摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides an adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

    摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

    Adipose-derived stem cells and lattices
    10.
    发明申请
    Adipose-derived stem cells and lattices 审中-公开
    脂肪来源的干细胞和晶格

    公开(公告)号：US20090181456A1

    公开(公告)日：2009-07-16

    申请号：US12315967

    申请日：2008-12-08

    申请人： Marc H. Hedrick ,  Adam J. Katz ,  Ramon Lluil ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

    发明人： Marc H. Hedrick ,  Adam J. Katz ,  Ramon Lluil ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90

    摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

    摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 在另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。