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    COMPOSITIONS AND METHODS FOR MODULAR SOFT TISSUE REPAIR
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULAR SOFT TISSUE REPAIR 审中-公开
    组合物和方法用于模块化软组织修复

    公开(公告)号：US20100098739A1

    公开(公告)日：2010-04-22

    申请号：US12580419

    申请日：2009-10-16

    申请人： Adam J. KATZ ,  Hulan SHANG

    发明人： Adam J. KATZ ,  Hulan SHANG

    IPC分类号： A61F2/00 ,  C12N11/00 ,  A61K35/12

    CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K35/28 ,  A61K35/35

    摘要： Adipose tissue-derived stromal cells induced to form multicellular aggregates can be formed reliably and consistently, they can be maintained for prolonged periods in adherent or suspension culture, and they are able to survive, grow, and/or differentiate in serum-free media conditions. The present invention provides compositions and methods for the use of such aggregates in tissue repair. This culture platform provides a controlled and defined system in which to study and standardize adult stem cell biology, and begets an instinctive “modular” approach to the predictable replacement and regeneration of adipose tissue.

    摘要翻译： 诱导形成多细胞聚集体的脂肪组织衍生的基质细胞可以可靠和一致地形成，它们可以在粘附或悬浮培养中保持长时间，并且它们能够在无血清培养基条件下存活，生长和/或分化 。 本发明提供了在组织修复中使用这种聚集体的组合物和方法。 这种培养平台提供了一个受控和定义的系统，用于研究和规范成体干细胞生物学，并产生本能的“模块化”方法来预测脂肪组织的替代和再生。

    Adipose-derived stem cells and lattices
    4.
    发明授权
    Adipose-derived stem cells and lattices 有权
    脂肪来源的干细胞和晶格

    公开(公告)号：US07470537B2

    公开(公告)日：2008-12-30

    申请号：US10740315

    申请日：2003-12-17

    申请人： Marc H. Hedrick ,  Adam J. Katz ,  Ramón Llull ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

    发明人： Marc H. Hedrick ,  Adam J. Katz ,  Ramón Llull ,  J. William Futrell ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90

    摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides an adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

    摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

    Adipose Tissue Stem Cells, Perivascular Cells and Pericytes
    5.
    发明申请
    Adipose Tissue Stem Cells, Perivascular Cells and Pericytes 审中-公开
    脂肪组织干细胞，血管周围细胞和周细胞

    公开(公告)号：US20080213235A1

    公开(公告)日：2008-09-04

    申请号：US11995408

    申请日：2006-07-28

    申请人： Adam J. Katz ,  Shayn Peirce Cottler

    发明人： Adam J. Katz ,  Shayn Peirce Cottler

    IPC分类号： A61K35/12 ,  C12N5/06 ,  A61P9/00

    CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00

    摘要： The present invention provides methods for growing and inducing perivascular cell differentiation of adipose tissue-derived stromal cells. The invention further provides methods for administering such adipose tissue-derived cells to a subject. The cells of the invention are useful for treating diseases, disorders, conditions, and injuries requiring new or enhanced angiogenesis, vascular remodeling, drug delivery, and tissue engineering.

    摘要翻译： 本发明提供了用于生长和诱导脂肪组织来源的基质细胞的血管周围细胞分化的方法。 本发明还提供了将这种脂肪组织衍生的细胞施用于受试者的方法。 本发明的细胞可用于治疗需要新的或增强的血管发生，血管重塑，药物递送和组织工程的疾病，病症，病症和损伤。

    High-throughput culture and transfer device and method
    6.
    发明授权
    High-throughput culture and transfer device and method 有权
    高通量培养和转移装置及方法

    公开(公告)号：US08980631B2

    公开(公告)日：2015-03-17

    申请号：US13381772

    申请日：2010-06-30

    申请人： Blair Taylor Stocks ,  Shayn Peirce Cottler ,  Adam J. Katz

    发明人： Blair Taylor Stocks ,  Shayn Peirce Cottler ,  Adam J. Katz

    IPC分类号： C12N5/02 ,  C12M1/12 ,  C12M1/32

    CPC分类号： C12M25/01 ,  C12M21/08 ,  C12M23/12 ,  C12M25/00 ,  C12M41/00

    摘要： A method and device for creating hanging drop cell aggregates. The method and device includes a plurality of pegs that allow for high throughput culture of aggregates. Also disclosed are means of transferring formed aggregates to various destinations, such as well plates, scaffolding, tissues, or wounds. Use of the device permits aggregates to be prepared or created in larger quantities than current methods, and allows for them to be transferred more efficiently.

    摘要翻译： 一种用于产生悬滴滴细胞聚集体的方法和装置。 该方法和装置包括允许聚集体的高通量培养的多个栓钉。 还公开了将形成的聚集体转移到各种目的地如孔板，脚手架，组织或伤口的手段。 使用该设备可以使聚合体以比当前方法更大的量来制备或创建，并且允许其更有效地转移。

    Methods and compositions useful for diabetic wound healing
    7.
    发明授权
    Methods and compositions useful for diabetic wound healing 有权
    用于糖尿病伤口愈合的方法和组合物

    公开(公告)号：US08835170B2

    公开(公告)日：2014-09-16

    申请号：US12444412

    申请日：2007-10-05

    申请人： Adam J. Katz ,  Anna M. Parker

    发明人： Adam J. Katz ,  Anna M. Parker

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/08 ,  C07K1/00 ,  C07K14/00 ,  A01N63/00 ,  A61K35/28 ,  A61K38/18 ,  A61K38/19

    CPC分类号： A61K35/28 ,  A61K38/18 ,  A61K38/19 ,  A61K2300/00

    摘要： The invention provides compositions and methods useful for treating wounds and enhancing wound healing, particularly for diabetic wound healing. One embodiment provides a method of treating a wound comprising administering to a subject in need thereof a therapeutically effective amount of adipose tissue derived stem cells to treat said wound, wherein the cells are cultured in the absence of serum prior to the administration to said subject. Another embodiment provides a method of treating a wound comprising administering to a subject in need thereof a therapeutically effective amount of adipose tissue derived stem cells to treat said wound, wherein the cells are cultured to induce the formation of at least one self-organizing mesenchymal blastema (SOMB) prior to the administration to said subject, wherein said SOMB is formed by culturing adipose tissue derived stem cells in hanging droplets.

    摘要翻译： 本发明提供了用于治疗伤口并增强伤口愈合的组合物和方法，特别是对于糖尿病伤口愈合。 一个实施方案提供了治疗伤口的方法，其包括向有需要的受试者施用治疗有效量的脂肪组织来源的干细胞以治疗所述伤口，其中在给予所述受试者之前，在不存在血清的情况下培养细胞。 另一个实施方案提供了一种治疗伤口的方法，其包括向有需要的受试者施用治疗有效量的脂肪组织来源的干细胞来治疗所述伤口，其中培养细胞以诱导形成至少一个自组织间充质胚乳 （SOMB），其中所述SOMB通过以悬浮液滴培养脂肪组织来源的干细胞形成。

    APPARATUS AND METHODS RELATING TO COLLECTING AND PROCESSING HUMAN BIOLOGICAL MATERIAL CONTAINING ADIPOSE
    8.
    发明申请
    APPARATUS AND METHODS RELATING TO COLLECTING AND PROCESSING HUMAN BIOLOGICAL MATERIAL CONTAINING ADIPOSE 有权
    与收集和处理含有ADIPOSE的人体生物材料相关的装置和方法

    公开(公告)号：US20130164731A1

    公开(公告)日：2013-06-27

    申请号：US13808550

    申请日：2011-07-08

    申请人： William W. Cimino ,  Adam J. Katz ,  Ramon Llull

    发明人： William W. Cimino ,  Adam J. Katz ,  Ramon Llull

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0653 ,  A61M1/0001 ,  A61M1/0094 ,  A61M1/0204 ,  A61M2202/08 ,  A61M2205/103 ,  C12M47/04

    摘要： A portable apparatus for collection and processing of human biological material containing adipose, such as extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material or fat graft material, which access may be via a lumen through a rotatable mixer shaft. Access ports may be configured for access only from above the container. The apparatus is incorporatable into a variety of assemblies, systems, kits, methods and uses.

    摘要翻译： 用于收集和加工含有脂肪的人体生物材料的便携式装置，例如在脂肪成形术过程中提取的，可用于多步骤加工以制备浓缩产物（例如基质血管部分）或脂肪移植组合物。 该装置具有容器，其具有容纳体积，具有组织保持体积，滤液体积由过滤器分离，并具有锥形部分，用于收集浓缩物产品的收集容积。 入口和吸入口分别提供对组织保持体积和滤液体积的访问，并且提取端口提供用于去除目标处理的浓缩物质或脂肪移植材料的通用途径，其可通过可旋转的混合器轴通过管腔进入。 访问端口可以被配置为仅从容器上方访问。 该装置可并入各种组件，系统，套件，方法和用途中。