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公开(公告)号：US20110015248A1
公开(公告)日：2011-01-20
申请号：US12350696
申请日：2009-01-08
申请人： Marc STADLER , Stephan Seip , Hartwig Müller , Anke Mayer-Bartschmid , Michael-Alexander Brüning , Jordi Benet-Buchholz , Hiroko Togame , Reiko Dodo , Peter Reinemer , Kevin Bacon , Kinji Fuchikami , Satoko Matsukawa , Klaus Urbahns
发明人： Marc STADLER , Stephan Seip , Hartwig Müller , Anke Mayer-Bartschmid , Michael-Alexander Brüning , Jordi Benet-Buchholz , Hiroko Togame , Reiko Dodo , Peter Reinemer , Kevin Bacon , Kinji Fuchikami , Satoko Matsukawa , Klaus Urbahns
IPC分类号： A61K31/407 , C07D491/044 , C07D207/277 , C07D207/28 , C12P17/18 , C12N1/20 , C12P17/10 , A61K31/4015 , A61P35/00 , A61P29/00
CPC分类号： C12P17/10 , C07D207/277 , C07D491/04 , C12P17/188 , C12R1/465
摘要： The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
摘要翻译： 本发明涉及取代的杂环，其制备方法及其在药物中的用途，特别是用于治疗炎性疾病，即哮喘或癌症。
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公开(公告)号：US20060229353A1
公开(公告)日：2006-10-12
申请号：US10545449
申请日：2004-02-06
申请人： Marc Stadler , Stephan Seip , Hartwig Müller , Anke Mayer-Bartschmid , Michael-Alexander Brüning , Jordi Benet-Buchholz , Hiroko Togame , Reiko Dodo , Peter Reinemer , Kevin Bacon , Kinji Fuchikami , Satoko Matsukawa , Klaus Urbahns
发明人： Marc Stadler , Stephan Seip , Hartwig Müller , Anke Mayer-Bartschmid , Michael-Alexander Brüning , Jordi Benet-Buchholz , Hiroko Togame , Reiko Dodo , Peter Reinemer , Kevin Bacon , Kinji Fuchikami , Satoko Matsukawa , Klaus Urbahns
IPC分类号： A61K31/407 , A61K31/4015 , C07D491/02
CPC分类号： C12P17/10 , C07D207/277 , C07D491/04 , C12P17/188 , C12R1/465
摘要： The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
摘要翻译： 本发明涉及取代的杂环，其制备方法及其在药物中的用途，特别是用于治疗炎性疾病，即哮喘或癌症。
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3.发明申请公开(公告)号：US20080064736A1
公开(公告)日：2008-03-13
申请号：US11572086
申请日：2005-07-09
申请人： Stefan Hillebrand , Oliver Guth , Welf-Burkhard Wiese , Klaus Kunz , Astrid Ullmann-Koppold , Amos Mattes , Peter Schreier , Ulrike Wachnedorff-Neumann , Karl-Heinz Kuck , Peter Losel , Olga Malsam , Peter Reinemer , Marc Stadler , Stefan Seip , Anke Mayer-Bartschmid , Hartwig Muller , Kevin Bacon , Mark Drewes , Kerstin Ilg
发明人： Stefan Hillebrand , Oliver Guth , Welf-Burkhard Wiese , Klaus Kunz , Astrid Ullmann-Koppold , Amos Mattes , Peter Schreier , Ulrike Wachnedorff-Neumann , Karl-Heinz Kuck , Peter Losel , Olga Malsam , Peter Reinemer , Marc Stadler , Stefan Seip , Anke Mayer-Bartschmid , Hartwig Muller , Kevin Bacon , Mark Drewes , Kerstin Ilg
IPC分类号： A01N43/36 , A01P3/00 , A01P7/04 , C07D207/28 , C07D491/044
CPC分类号： C07D207/416 , C07D207/28 , C07D491/04
摘要： The use of a compound of formula (I) or a salt thereof, where the symbols have the meanings given in the description, for the control of phytopathogenic mircroorganisms of harmful animals.
摘要翻译： 使用式（I）化合物或其盐，其中符号具有说明书中给出的含义，用于控制有害动物的植物病原性微生物。
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公开(公告)号：US20140050743A1
公开(公告)日：2014-02-20
申请号：US13980431
申请日：2012-01-17
申请人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
发明人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , A61K2039/505 , A61K2300/00 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本发明涉及抗原结合区，抗体，抗原结合抗体片段和抗体模拟物的鉴定和用途，其中和抗凝血剂在体外和/或体内的抗凝血作用。 本发明的抗体和功能片段和抗体模拟物可用于特异性地逆转抗凝血剂的药理学作用。 用于治疗（解毒剂）和/或诊断目的的FXa抑制剂。 本发明还提供了编码前述分子的核酸序列，含有该分子的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：US20090253848A1
公开(公告)日：2009-10-08
申请号：US12419536
申请日：2009-06-22
IPC分类号： C08K3/08
CPC分类号： A61L27/54 , A01N59/16 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/624 , C08G18/12 , C08G18/283 , C08G18/44 , C08G18/4854 , C08G18/664 , C08G18/6674 , C08G18/755 , C08G18/758 , C09D175/04 , A01N25/04 , A01N25/10 , A01N2300/00 , C08L75/04 , C08G18/3228
摘要： The present invention relates to an aqueous dispersion comprising at least one nonionically stabilized polyurethaneurea and at least one silver-containing constituent.
摘要翻译： 本发明涉及包含至少一种非离子稳定的聚氨酯脲和至少一种含银组分的水分散体。
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公开(公告)号：US20120321619A1
公开(公告)日：2012-12-20
申请号：US13514789
申请日：2010-12-08
申请人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
发明人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
IPC分类号： C07K16/30 , C12N15/85 , A61P35/04 , C12P21/08 , A61K39/395 , C12N1/21 , C12N15/13 , C12N5/10
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本发明提供重组抗原结合区和抗体以及含有对多个肿瘤中过表达的膜锚定的29kDa C4,4a多肽具有特异性的此类抗原结合区的功能片段。 肺，结肠直肠，胰腺，前列腺，肾和乳腺癌。 因此，这些抗体可用于治疗这些和其他病症和病症。 本发明的抗体也可用于诊断领域，以及用于进一步研究C4.4a在与癌症相关疾病进展中的作用。 本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：US20090252804A1
公开(公告)日：2009-10-08
申请号：US12419597
申请日：2009-04-07
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , C08L75/04
摘要： The present invention relates to a medical device which has at least one coating which is obtained starting from an aqueous dispersion, the aqueous dispersion comprising at least one nonionically stabilized polyurethaneurea and at least one silver-containing constituent.
摘要翻译： 本发明涉及一种具有至少一种从水分散体开始获得的涂层的医疗装置，所述水性分散体包含至少一种非离子稳定的聚氨酯脲和至少一种含银组分。
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