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    MULTICOLUMN SEQUENTIAL SEPARATION PROCESS
    1.
    发明申请
    MULTICOLUMN SEQUENTIAL SEPARATION PROCESS 有权
    多元顺序分离方法

    公开(公告)号：US20090209736A1

    公开(公告)日：2009-08-20

    申请号：US12304840

    申请日：2007-06-18

    申请人： Marc-André Theoleyre ,  Stanislas Baudouin ,  Annick Merrien ,  Eric Valery ,  Olivier Ludemann-Hombourger ,  Laurent David ,  Margit Holzer

    发明人： Marc-André Theoleyre ,  Stanislas Baudouin ,  Annick Merrien ,  Eric Valery ,  Olivier Ludemann-Hombourger ,  Laurent David ,  Margit Holzer

    IPC分类号： C07K1/22 ,  C07K1/18

    CPC分类号： B01D15/1871 ,  B01D15/1828 ,  B01D15/361 ,  B01D15/3804

    摘要： The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow means being placed between adjacent zones and between the last zone and the first zone, this process comprising several sequences, each sequence comprising at least one step chosen from an absorption step, a rinsing step and a desorption step, carried out either simultaneously or not, each following sequence is carried out by the displacement of the fronts in the zones towards the downstream end substantially of the same increment before the periodic displacement of the points of introduction and of withdrawal, characterized in that the process includes a sub-sequence without injection of the charge.

    摘要翻译： 本发明的主题是通过多柱顺序选择性保留在固体支持物上进行分离，以便通过将该溶液通过固定的色谱树脂床分离感兴趣的产物与含有目的产物的溶液，所述固定支架包含至少三个 区域，液体流动装置被放置在相邻区域之间以及最后区域和第一区域之间，该方法包括几个序列，每个序列包括至少一个选自吸收步骤，漂洗步骤和解吸步骤的步骤， 通过在引入点和撤出点的周期性位移之前，通过在区域中的前端向下游端基本上相同增量的位移来执行每个后续顺序，其特征在于， 序列而不注入电荷。

    Juicer having an articulated arm carrying a pressing element
    2.
    发明授权
    Juicer having an articulated arm carrying a pressing element 失效
    榨汁机具有携带按压元件的铰接臂

    公开(公告)号：US07267050B2

    公开(公告)日：2007-09-11

    申请号：US11373124

    申请日：2006-03-13

    申请人： Cyril Durris ,  Laurent David ,  Marc Suberbie

    发明人： Cyril Durris ,  Laurent David ,  Marc Suberbie

    IPC分类号： B30B9/08 ,  A23N1/00

    CPC分类号： A47J19/027

    摘要： A juicer composed of: a housing provided to receive a rotatable element for extraction of juice; an arm that is mounted to the housing to pivot about an axis with respect to the housing; a pressing element for pressing a fruit half against the rotatable element; and a pivot element mounting the pressing element to the arm to pivot about a pivot axis with respect to the arm.

    摘要翻译： 一种榨汁机，由以下部件组成：一个壳体，用于接收用于提取果汁的可转动元件; 臂，其安装到壳体以相对于壳体绕轴线枢转; 用于将果半部压在可旋转元件上的按压元件; 以及枢轴元件，其将所述按压元件安装到所述臂以相对于所述臂绕枢转轴线枢转。

    Method and device for restoring a light signal
    4.
    发明授权
    Method and device for restoring a light signal 失效
    恢复光信号的方法和装置

    公开(公告)号：US06911977B2

    公开(公告)日：2005-06-28

    申请号：US10181675

    申请日：2001-01-15

    申请人： Laurent David ,  Samuel Carre

    发明人： Laurent David ,  Samuel Carre

    IPC分类号： G03B21/60 ,  G03B21/00 ,  H04N5/74 ,  H04N9/31 ,  G06T15/60

    CPC分类号： H04N9/3185

    摘要： A method for restoring a light signal from digital data defining a colorimetric coordinate of the light signal in a specific colorimetric system, comprises the step of generating a first light signal using a first light restoration unit, the step of generating a second light signal using a second light restoration unit, and the step of generating a third light signal obtained by superimposing the first and second light signals. The second light restoration unit covers a brightness dynamics less than the brightness dynamics covered by the first restoration light unit. The second light restoration unit has a brightness resolution finer than the first light restoration unit.

    摘要翻译： 一种用于在特定比色系统中定义光信号的比色坐标的数字数据中恢复光信号的方法包括使用第一光恢复单元生成第一光信号的步骤，使用第 第二光恢复单元，以及产生通过叠加第一和第二光信号而获得的第三光信号的步骤。 第二光恢复单元覆盖比由第一恢复光单元覆盖的亮度动态小的亮度动态。 第二光恢复单元具有比第一光恢复单元更精细的亮度分辨率。

    Chitosan yarn having a crystal structure corresponding to the anhydrous allomorph and a tensile strength, after immersion in demineralized water for fifteen hours, of at least 150 MPA
    5.
    发明授权
    Chitosan yarn having a crystal structure corresponding to the anhydrous allomorph and a tensile strength, after immersion in demineralized water for fifteen hours, of at least 150 MPA 有权
    具有对应于无水异构体的晶体结构的壳聚糖纱线和在软化水中浸泡15小时后的拉伸强度为至少150MPA

    公开(公告)号：US09238880B2

    公开(公告)日：2016-01-19

    申请号：US13201489

    申请日：2010-02-15

    申请人： Alain Domard ,  Laurent David ,  Alexandra Montembault ,  Mylène Desorme

    发明人： Alain Domard ,  Laurent David ,  Alexandra Montembault ,  Mylène Desorme

    IPC分类号： D01F2/08 ,  D01F9/00 ,  D01D5/06 ,  D01F2/24

    CPC分类号： D01F9/00 ,  B29C47/0014 ,  B29C47/8805 ,  B29C47/8895 ,  D01D5/06 ,  D01F2/24

    摘要： The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element. The chitosan thread has a crystalline structure corresponding to the anhydrous allomorph and a rupture stress of at least 150 MPa after being immersed in demineralized water for fifteen hours. The apparatus (1) for the wet extrusion of polysaccharide thread (10) includes an extruder (2) with at least one extrusion die (3), an evaporation enclosure (4) placed immediately after the output (3a) of the extrusion die (3) and supplied with a hot air flow, a neutralization unit (5), a washing unit (6), a drying unit (8) and a winding unit (9).

    摘要翻译： 本发明涉及一种用于生产细长多糖元件，特别是壳聚糖螺纹的方法，其包括通过挤出模挤出所述多糖的可渗透溶液的操作和使挤出溶液凝结的操作。 可膨胀溶液是含有在大气压下不与水形成共沸物并且沸点大于150℃的醇的水醇溶液。 凝结操作包括蒸发水，优选在醇上的步骤，产生主要为醇凝胶形式的凝胶化挤出细长元件，特别是通过将挤出的溶液经受热空气流。 消除所述凝胶中所含的醇的至少一种操作使得可以获得细长多糖元件。 壳聚糖螺纹具有对应于无水异构体的晶体结构，并且在浸入软化水​​中15小时后的破裂应力至少为150MPa。 用于多糖螺纹（10）的湿挤压的装置（1）包括具有至少一个挤出模头（3）的挤出机（2），紧紧在挤出模头的输出（3a）之后放置的蒸发外壳（4） 供给热风流，中和单元（5），清洗单元（6），干燥单元（8）和卷绕单元（9）。

    METHOD FOR OBTAINING AN ELONGATE POLYSACCHARIDE ELEMENT, IN PARTICULAR A CHITOSAN THREAD
    6.
    发明申请
    METHOD FOR OBTAINING AN ELONGATE POLYSACCHARIDE ELEMENT, IN PARTICULAR A CHITOSAN THREAD 有权
    用于获得优质多糖元件的方法，特别是木质螺纹

    公开(公告)号：US20130252498A1

    公开(公告)日：2013-09-26

    申请号：US13582537

    申请日：2011-03-04

    申请人： Laurent David ,  Alexandra Montembault ,  Mylène Desorme

    发明人： Laurent David ,  Alexandra Montembault ,  Mylène Desorme

    IPC分类号： C08B37/00 ,  B32B27/02

    CPC分类号： C08B37/0024 ,  B32B27/02 ,  D01D5/06 ,  D01F9/00 ,  D01F9/04 ,  Y10T428/2975 ,  Y10T442/431

    摘要： A method for obtaining an elongate polysaccharide element, in particular a chitosan thread, includes extruding a hydroalcoholic extrusible solution containing a polyalcohol of said polysaccharide through an extrusion die, coagulating the extruded solution by neutralisation, and at least one operation of removing the polyalcohol. The ratio of water to polyalcohol in the extrusible solution is determined such as to obtain in the elongate element a polysaccharide with the crystalline structure thereof mainly in the form of an anhydrous allomorph. Since the polysaccharide used to prepare the extrusible solution has a weight-average molar mass Mw0, the polysaccharide in the elongate element obtained preferably has a weight-average molar mass Mw1 comprised between Mw0 and 0.7 Mw0. Since the purpose is to obtain a chitosan thread, the latter has properties of mechanical strength and flexibility that allow the thread to be tied into overhand knots and to be woven without breaking.

    摘要翻译： 用于获得细长多糖元件，特别是壳聚糖丝线的方法包括通过挤出模头挤出含有所述多糖的多元醇的水醇可渗溶溶液，通过中和凝结挤出的溶液，以及至少一种除去多元醇的操作。 确定可挤出溶液中的水与多元醇的比例，以便在细长元件中获得其结晶结构的多糖主要是无水异构体形式的多糖。 由于用于制备可膨胀溶液的多糖具有重均摩尔质量Mw0，所获得的细长元件中的多糖优选具有Mw0至0.7Mw0之间的重均摩尔质量Mw1。 由于目的是获得一种壳聚糖螺纹，后者具有机械强度和柔韧性的特性，允许将螺纹捆扎成过度的结，并且不会断裂。

    Azaindole compounds as kinase inhibitors
    7.
    发明申请
    Azaindole compounds as kinase inhibitors 审中-公开
    Azaindole化合物作为激酶抑制剂

    公开(公告)号：US20060287354A1

    公开(公告)日：2006-12-21

    申请号：US10556227

    申请日：2004-05-06

    申请人： Laurent David ,  Peter Hansen

    发明人： Laurent David ,  Peter Hansen

    IPC分类号： A61K31/4745 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present invention relates to novel azaindole compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them.

    摘要翻译： 本发明涉及作为激酶抑制剂的新型氮杂吲哚化合物，其制备中间体的方法和包含它们的药物组合物。

    Juicer having an articulated arm carrying a pressing element
    8.
    发明申请
    Juicer having an articulated arm carrying a pressing element 失效
    榨汁机具有携带按压元件的铰接臂

    公开(公告)号：US20060207445A1

    公开(公告)日：2006-09-21

    申请号：US11373124

    申请日：2006-03-13

    申请人： Cyril Durris ,  Laurent David ,  Marc Suberbie

    发明人： Cyril Durris ,  Laurent David ,  Marc Suberbie

    IPC分类号： B30B9/02

    CPC分类号： A47J19/027

    摘要： A juicer composed of: a housing provided to receive a rotatable element for extraction of juice; an arm that is mounted to the housing to pivot about an axis with respect to the housing; a pressing element for pressing a fruit half against the rotatable element; and a pivot element mounting the pressing element to the arm to pivot about a pivot axis with respect to the arm.

    摘要翻译： 一种榨汁机，由以下部件组成：一个壳体，用于接收用于提取果汁的可转动元件; 臂，其安装到壳体以相对于壳体绕轴线枢转; 用于将果半部压在可旋转元件上的按压元件; 以及枢轴元件，其将所述按压元件安装到所述臂以相对于所述臂绕枢转轴线枢转。

    METHOD FOR PRODUCING AN ELONGATE POLYSACCHARIDE ELEMENT, IN PARTICULAR A CHITOSAN THREAD, AND POLYSACCCHARIDE THREAD OBTAINED
    9.
    发明申请
    METHOD FOR PRODUCING AN ELONGATE POLYSACCHARIDE ELEMENT, IN PARTICULAR A CHITOSAN THREAD, AND POLYSACCCHARIDE THREAD OBTAINED 有权
    生产优质多糖元素的方法，特别是芝士螺纹和多晶硅螺纹获得

    公开(公告)号：US20120022242A1

    公开(公告)日：2012-01-26

    申请号：US13201489

    申请日：2010-02-15

    申请人： Alain Domard ,  Laurent David ,  Alexandra Montembault ,  Mylène Desorme

    发明人： Alain Domard ,  Laurent David ,  Alexandra Montembault ,  Mylène Desorme

    IPC分类号： C08B37/08 ,  B29C47/88 ,  D01F2/08 ,  B29C47/78 ,  D01D5/06

    CPC分类号： D01F9/00 ,  B29C47/0014 ,  B29C47/8805 ,  B29C47/8895 ,  D01D5/06 ,  D01F2/24

    摘要： The invention relates to a method for producing an elongate polysaccharide element, in particular a chitosan thread, comprising an operation of extruding an extrusible solution of said polysaccharide through an extrusion die and an operation of coagulating the extruded solution. The extrusible solution is a hydroalcoholic solution containing an alcohol that does not form an azeotrope with water and which has a boiling point of more than 150° C. at atmospheric pressure. The coagulation operation includes a step of evaporating the water, preferably over the alcohol, producing a gelled extruded elongate element in the form of a mainly alcoholic gel, in particular by subjecting the extruded solution to a hot air flow. At least one operation of eliminating the alcohol contained in said gel makes it possible to obtain the elongate polysaccharide element. The chitosan thread has a crystalline structure corresponding to the anhydrous allomorph and a rupture stress of at least 150 MPa after being immersed in demineralised water for fifteen hours. The apparatus (1) for the wet extrusion of polysaccharide thread (10) includes an extruder (2) with at least one extrusion die (3), an evaporation enclosure (4) placed immediately after the output (3a) of the extrusion die (3) and supplied with a hot air flow, a neutralisation unit (5), a washing unit (6), a drying unit (8) and a winding unit (9).

    摘要翻译： 本发明涉及一种用于生产细长多糖元件，特别是壳聚糖螺纹的方法，其包括通过挤出模挤出所述多糖的可渗透溶液的操作和使挤出溶液凝结的操作。 可膨胀溶液是含有在大气压下不与水形成共沸物并且沸点大于150℃的醇的水醇溶液。 凝结操作包括蒸发水，优选在醇上的步骤，产生主要为醇凝胶形式的凝胶化挤出细长元件，特别是通过将挤出的溶液经受热空气流。 消除所述凝胶中所含的醇的至少一种操作使得可以获得细长多糖元件。 壳聚糖螺纹具有对应于无水异构体的晶体结构，并且在浸入软化水​​中15小时后的破裂应力至少为150MPa。 用于多糖螺纹（10）的湿挤压的装置（1）包括具有至少一个挤出模头（3）的挤出机（2），紧紧在挤出模头的输出（3a）之后放置的蒸发外壳（4） 供给热风流，中和单元（5），清洗单元（6），干燥单元（8）和卷绕单元（9）。