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公开(公告)号:US20130066320A1
公开(公告)日:2013-03-14
申请号:US13637345
申请日:2011-03-23
CPC分类号: A61B17/72 , A61B17/88 , A61L31/022 , A61L31/06 , C08L71/00
摘要: A titanium body (2) of a femoral nail incorporates an opening (3) leading into a hollow region (4) which defines a cavity in which electronics may be incorporated. A potting compound overlays the electronics, within the region (4). A 100 to 150 μm thick cover (18) made from polyetheretherketone is arranged to overlay the opening (3) and close the hollow region (4). The cover (18) is made from flat polyetheretherketone film of suitable thickness which is heat shrunk onto a former and then machined to define the desired shape.
摘要翻译: 股骨钉的钛体(2)包括通向中空区域(4)的开口(3),所述中空区域(4)限定可以并入电子器件的空腔。 灌封组合物覆盖在区域内的电子部件(4)。 设置由聚醚醚酮制成的厚度为100〜150μm的盖(18),覆盖开口(3)并封闭中空区域(4)。 盖(18)由适当厚度的平坦聚醚醚酮薄膜制成,该薄膜热收缩到前者上,然后加工以确定所需的形状。
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公开(公告)号:US20120203317A1
公开(公告)日:2012-08-09
申请号:US13382071
申请日:2010-07-02
CPC分类号: A61N1/375 , A61N1/3787 , C08G2650/40 , C08L71/00 , C08L81/06 , Y10T29/49826
摘要: An enclosure of an active implantable device comprises a composite material which comprises a first layer of a polyetheretherketone film, a second layer of polyetheretherketone film (8) and, sandwiched between, a third layer comprising titanium. The arrangement may be provided in various embodiments such as comprising housing halves (70,72) and a lid (74), each being made of the three layers described. In one embodiment, a communications window may be provided which has a thinner layer of titanium, to facilitate communications between the outside and electrical components positioned within the enclosure.
摘要翻译: 活性可植入装置的外壳包括复合材料,该复合材料包括第一层聚醚醚酮膜,第二层聚醚醚酮膜(8),夹在第三层钛之间。 该布置可以在各种实施例中提供,例如包括壳体半部(70,72)和盖(74),每个由所述三层制成。 在一个实施例中,可以提供通信窗口,其具有较薄的钛层,以便于位于外壳内的外部和电气部件之间的通信。
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公开(公告)号:US20140200466A1
公开(公告)日:2014-07-17
申请号:US14128686
申请日:2012-06-21
CPC分类号: A61L31/06 , A61B5/6869 , A61L27/18 , A61N1/36 , C08G2650/40 , C08L71/00 , C08L81/06 , Y10T428/24479
摘要: Topographical features, such as projections or recesses, having a maximum dimension which is less than 3 μm, with the features being separated by a distance which is less than 10 μm are transferred to polyetheretherketone, on an industrial scale, by injection moulding relatively low viscosity PEEK, using a mould in which is arranged a master structure which carries the desired topography. The topographical features increase the water contact angle of a surface which includes them and such a modified surface has been shown to influence cell attachment and differentiation. Parts which incorporate the topographical features may be used in medical devices such as implantable medical devices for cardiology or for neuromodulation.
摘要翻译: 具有小于3μm的最大尺寸的形状特征,例如具有小于10μm的距离的特征被放置在工业规模上,通过注塑相对低的粘度转移到聚醚醚酮 PEEK,使用其中布置有携带所需形貌的主结构的模具。 形貌特征增加包括它们的表面的水接触角,并且已经显示这种改性表面影响细胞附着和分化。 结合地形特征的部件可以用于诸如用于心脏病学的植入式医疗装置或用于神经调节的医疗装置中。
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公开(公告)号:US20110151259A1
公开(公告)日:2011-06-23
申请号:US13054227
申请日:2009-07-14
CPC分类号: C08J9/26 , C08J3/203 , C08J2201/044 , C08J2201/0442 , C08J2201/0444 , C08J2371/10 , Y10T428/2982
摘要: Pellets or granules comprise polymeric material, for example polyetheretherketone and a fugitive material, for example sodium chloride. The granules may be used in injection moulding to produce shapes for use in medical implants and may conveniently be used to form parts which are partially porous, or to prepare porous films.
摘要翻译: 颗粒或颗粒包括聚合物材料,例如聚醚醚酮和短效材料,例如氯化钠。 颗粒可以用于注射成型以产生用于医用植入物的形状,并且可以方便地用于形成部分多孔的部件或制备多孔膜。
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公开(公告)号:US20140035201A1
公开(公告)日:2014-02-06
申请号:US13985457
申请日:2012-02-14
申请人: Marcus Jarman-Smith , Mark Brady , John Devine , Keith Cartwright
发明人: Marcus Jarman-Smith , Mark Brady , John Devine , Keith Cartwright
IPC分类号: B29C45/00
CPC分类号: B29C45/0001 , A61L27/46 , C08J3/201 , C08J3/203 , C08J9/0066 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2371/12 , C08K3/32 , C08K2003/325 , C08L71/00
摘要: There are provided methods of producing a component incorporating a bioactive material. In one embodiment the method comprises: (a) using a screw extruder to mix a polymeric material (I) with a bioactive material (II) and melt the polymeric material (I); and (b) making a component by moulding; and wherein the polymeric material (I) is of a type which includes: (i) phenyl moieties; (ii) ketone moieties; and (iii) ether moieties. Also provided are components comprising a polymeric material and a bioactive material.
摘要翻译: 提供了生产包含生物活性材料的组分的方法。 在一个实施方案中,该方法包括:(a)使用螺杆挤出机将聚合材料(I)与生物活性材料(II)混合并熔化聚合材料(I); 和(b)通过模塑制成组分; 并且其中所述聚合物材料(I)是一种类型,其包括:(i)苯基部分; (ii)酮部分; 和(iii)醚部分。 还提供了包含聚合物材料和生物活性材料的组分。
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公开(公告)号:US20110287508A1
公开(公告)日:2011-11-24
申请号:US12678849
申请日:2008-09-19
摘要: Bioreactors and methods of using them to produce tissue engineered products or culture cells are disclosed, and more particularly on the development of a tissue and cell culture method based upon an expanded bed bioreactor in which an initial resting bed of particles on which or in which cells are attached, encapsulated or immobilised have a fluid passed upwards through the bed to form an expanded bed in which the fluid acts to separate the particles, i.e. under plug flow conditions to enable the relative positions of the particles to be maintained during the step of culturing the cells to form tissue and helps to reduce collisions between particles and turbulent flow or convective mixing.
摘要翻译: 公开了使用它们来生产组织工程化产物或培养细胞的生物反应器和方法,更具体地说,涉及基于扩张床生物反应器的组织和细胞培养方法的开发,其中在其上或其中的细胞的初始沉积床 附着,包封或固定的流体通过床向上通过以形成膨胀床,其中流体用于分离颗粒,即在活塞流动条件下,使得在培养步骤期间保持颗粒的相对位置 细胞形成组织并有助于减少颗粒之间的碰撞和湍流或对流混合。
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公开(公告)号:US20110230590A1
公开(公告)日:2011-09-22
申请号:US13124300
申请日:2009-10-14
CPC分类号: A61L27/446 , C08K3/40
摘要: Granules or pellets comprising polymeric materials such as polyaryletherketones and ceramic materials may be prepared and used to make a variety of different parts of components for use in medical applications, by melt-processing. The ceramic material may be a bioactive glass and/or a controlled-release glass, and may include less than 20 mole % sodium oxide and/or be water soluble.
摘要翻译: 可以制备包含聚合物材料如聚芳醚酮和陶瓷材料的颗粒或丸粒,并用于通过熔融加工制备用于医疗应用的各种不同部件组分。 陶瓷材料可以是生物活性玻璃和/或控释玻璃,并且可以包括小于20摩尔%的氧化钠和/或水溶性。
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公开(公告)号:US08729150B2
公开(公告)日:2014-05-20
申请号:US13124300
申请日:2009-10-14
IPC分类号: A61F2/28
CPC分类号: A61L27/446 , C08K3/40
摘要: Granules or pellets comprising polymeric materials such as polyaryletherketones and ceramic materials may be prepared and used to make a variety of different parts of components for use in medical applications, by melt-processing. The ceramic material may be a bioactive glass and/or a controlled-release glass, and may include less than 20 mole % sodium oxide and/or be water soluble.
摘要翻译: 可以制备包含聚合物材料如聚芳醚酮和陶瓷材料的颗粒或丸粒,并用于通过熔融加工制备用于医疗应用的各种不同部件组分。 陶瓷材料可以是生物活性玻璃和/或控释玻璃,并且可以包括小于20摩尔%的氧化钠和/或水溶性。
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