-
公开(公告)号：US20060058236A1
公开(公告)日：2006-03-16
申请号：US11217536
申请日：2005-08-31
申请人： Maria Hutchins , Radwan Kiwan , Samuel Zalipsky
发明人： Maria Hutchins , Radwan Kiwan , Samuel Zalipsky
IPC分类号： A61K38/38
CPC分类号： A61K47/643 , A61K47/60
摘要： A conjugate formed in vivo and comprised of endogenous albumin and an amine-containing compound, such as a protein or a drug, is described. The conjugate is formed by in vivo cleavage of a polymer-dithiobenzyl-therapeutic agent conjugate to form an albumin-dithiobenzyl-therapeutic agent conjugate. The dithiol moiety of the albumin-therapeutic agent conjugate is cleaved in vivo to yield the free therapeutic agent in native form.
摘要翻译： 描述了在体内形成的由内源白蛋白和含胺化合物如蛋白质或药物组成的缀合物。 通过体内裂解聚合物 - 二硫代苄基治疗剂缀合物形成白蛋白 - 二硫代苄基治疗剂缀合物来形成缀合物。 白蛋白治疗剂缀合物的二硫醇部分在体内裂解以产生天然形式的游离治疗剂。
-
公开(公告)号：US07592307B2
公开(公告)日：2009-09-22
申请号：US11810931
申请日：2007-06-06
申请人： Samuel Zalipsky , Radwan Kiwan
发明人： Samuel Zalipsky , Radwan Kiwan
CPC分类号： A61K47/554 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/60
摘要： A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
摘要翻译： 描述了由共价但可逆地连接到含胺，羟基或羧基的配体的亲水性聚合物组成的缀合物。 所得的缀合物能够通过硫醇介导的切割释放母体胺，羟基或含羧基的化合物。 该系统允许以其可硫裂解的大分子缀合物的形式递送各种氨基，羟基或羧基的药物。
-
公开(公告)号：US20080279922A1
公开(公告)日：2008-11-13
申请号：US11810931
申请日：2007-06-06
申请人： Samuel Zalipsky , Radwan Kiwan
发明人： Samuel Zalipsky , Radwan Kiwan
CPC分类号： A61K47/554 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/60
摘要： A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
摘要翻译： 描述了由共价但可逆地连接到含胺，羟基或羧基的配体的亲水性聚合物组成的缀合物。 所得的缀合物能够通过硫醇介导的切割释放母体胺，羟基或含羧基的化合物。 该系统允许以其可硫裂解的大分子缀合物的形式递送各种氨基，羟基或羧基的药物。
-
公开(公告)号：US20070015701A1
公开(公告)日：2007-01-18
申请号：US11444598
申请日：2006-05-31
申请人： Samuel Zalipsky , Francis Farrell , Beth Hill , Radwan Kiwan
发明人： Samuel Zalipsky , Francis Farrell , Beth Hill , Radwan Kiwan
IPC分类号： A61K38/18
CPC分类号： A61K38/1875 , A61K47/60
摘要： A modified bone morphogenetic protein (BMP, also referred to as bone morphogenic protein) composition is described. The bone morphogenetic protein, in one embodiment, is BMP-7 which is chemically modified with a hydrophilic polymer, such as poly(ethylene glycol).
摘要翻译： 描述了修饰的骨形态发生蛋白（BMP，也称为骨形态发生蛋白）组合物。 在一个实施方案中，骨形态发生蛋白是BMP-7，其用亲水性聚合物如聚（乙二醇）化学改性。
-
公开(公告)号：US07238368B2
公开(公告)日：2007-07-03
申请号：US10723473
申请日：2003-11-26
申请人： Samuel Zalipsky , Radwan Kiwan
发明人： Samuel Zalipsky , Radwan Kiwan
CPC分类号： A61K47/554 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/60
摘要： A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
摘要翻译： 描述了由共价但可逆地连接到含胺，羟基或羧基的配体的亲水性聚合物组成的缀合物。 所得的缀合物能够通过硫醇介导的切割释放母体胺，羟基或含羧基的化合物。 该系统允许以其可硫裂解的大分子缀合物的形式递送各种氨基，羟基或羧基的药物。
-
6.发明申请公开(公告)号：US20060286657A1
公开(公告)日：2006-12-21
申请号：US11445833
申请日：2006-06-01
申请人： Samuel Zalipsky , Radwan Kiwan
发明人： Samuel Zalipsky , Radwan Kiwan
IPC分类号： C12N9/36 , C07K14/505 , C07K14/475
CPC分类号： A61K47/60
摘要： A method for conjugation of PEG to a protein in an aqueous solution at a pH less than or equal to about 7.0 or neutral pH comprising combining an activated PEG reagent and a protein in the presence of an activating agent at a pH of less than about 7.0 or neutral pH. In one embodiment, the method produces mixed populations of moderately PEGylated proteins, including 1:1, 2:1, and 3:1 PEGylated proteins.
摘要翻译： 一种用于在pH小于或等于约7.0或中性pH的水溶液中将PEG与蛋白质缀合的方法，包括在活性剂存在下，在小于约7.0的pH下组合活化的PEG试剂和蛋白质 或中性pH。 在一个实施方案中，该方法产生中等聚乙二醇化蛋白质的混合群体，包括1:2,2:1和3:1聚乙二醇化蛋白质。
-
公开(公告)号：US07303760B2
公开(公告)日：2007-12-04
申请号：US10714085
申请日：2003-11-14
申请人： Samuel Zalipsky , Alberto Gabizon
发明人： Samuel Zalipsky , Alberto Gabizon
IPC分类号： A61K9/127 , C07F9/02 , C07F53/00 , C07F321/00
CPC分类号： A61K31/407 , A61K47/543 , A61K47/6911
摘要： Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.
摘要翻译： 描述了向多药耐药细胞施用丝裂霉素C并降低化合物的毒性的方法。 在该方法中，丝裂蛋白C以前体药物缀合物的形式提供，其中药物通过可裂解的二硫代苄基键连接到疏水部分，例如脂质。 二硫代苄基键易受到轻度硫解的裂解，导致丝裂霉素C以其原始形式释放。 在非还原条件下，连接是稳定的。 可以将前体药物缀合物掺入用于体内施用的体内脂质体中，并响应内源性体内还原条件或响应外源性还原剂的施用而释放丝裂霉素C.
-
公开(公告)号：US07276248B2
公开(公告)日：2007-10-02
申请号：US11202913
申请日：2005-08-12
IPC分类号： A61K9/127 , C07F9/02 , C07F53/00 , C07C321/00
CPC分类号： A61K9/1271 , A61K9/0019 , A61K31/196 , A61K31/407 , A61K31/519 , A61K31/56 , A61K38/14 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/554 , A61K47/60 , A61K47/6911 , C07C323/19 , C07D239/553 , C07D487/14 , C07H17/08 , C07H19/12 , C07H19/16 , Y10T428/2984
摘要： Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.
摘要翻译： 描述了通过可切割二硫代苄基键连接到治疗剂的疏水部分（例如脂质）的缀合物。 二硫代苄基键易受到轻度硫解的裂解，导致治疗剂以其原始形式释放。 在非还原条件下，连接是稳定的。 缀合物可以并入脂质体中，用于体内施用和响应于体内还原条件或响应于外源性还原剂的施用释放治疗剂。
-
公开(公告)号：US07160554B2
公开(公告)日：2007-01-09
申请号：US10438502
申请日：2003-05-14
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
摘要翻译： 公开了包含小的表面结合效应分子的脂质体组合物。 脂质体具有亲水性聚合物链的表面层，用于增强血流中的循环时间。 效应分子连接到聚合物链的末端。 在一个实施方案中，效应物是多粘菌素B，用于治疗败血性休克。
-
公开(公告)号：US07150882B2
公开(公告)日：2006-12-19
申请号：US10832636
申请日：2004-04-26
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
-
-
-
-
-
-
-
-
-
搜索结果
65 条记录 (耗时 0.03 秒)
