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1.发明申请Adenoviral vector-mediated delivery of modified steroid hormone receptors and related products and methods 审中-公开腺病毒载体介导的修饰类固醇激素受体的递送及相关产品及方法公开(公告)号：US20050196751A1
公开(公告)日：2005-09-08
申请号：US09861181
申请日：2001-05-18
申请人： Mark Burcin , Bert O'Malley , Gudrun Schiedner , Sophia Tsai , Stefan Kochanek
发明人： Mark Burcin , Bert O'Malley , Gudrun Schiedner , Sophia Tsai , Stefan Kochanek
IPC分类号： A61K48/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/72 , C12N15/63 , C12N15/861 , C12Q1/68
CPC分类号： C12N15/86 , A01K2217/05 , A61K48/00 , C07K14/721 , C12N15/63 , C12N2710/10343 , C12N2830/008 , C12N2830/40
摘要： The present invention relates to adenoviral delivery of modified steroid hormone receptor proteins. The adenoviral vector preferably contains no viral coding sequence and is capable of accepting a large insert. Such vectors preferably are capable of achieving high levels and durations of delivery and expression. The modified protein preferably is capable of distinguishing a hormone agonist from an antagonist and may be modified in the ligand binding domain, the DNA binding domain, and/or the transregulatory domain.
摘要翻译： 本发明涉及修饰的类固醇激素受体蛋白的腺病毒递送。 腺病毒载体优选不含病毒编码序列，并且能够接受大的插入片段。 这样的载体优选能够实现递送和表达的高水平和持续时间。 修饰的蛋白质优选能够区分激素激动剂和拮抗剂，并且可以在配体结合结构域，DNA结合结构域和/或跨调节结构域中进行修饰。
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2.发明授权公开(公告)号：US07579326B2
公开(公告)日：2009-08-25
申请号：US10400053
申请日：2003-03-25
申请人： Ronald V Abruzzese , Vidya Mehta , Jeffrey L Nordstrom , Jason Fewell , Bert O'Malley , Sophia Tsai
发明人： Ronald V Abruzzese , Vidya Mehta , Jeffrey L Nordstrom , Jason Fewell , Bert O'Malley , Sophia Tsai
IPC分类号： A01N43/04 , A61K31/70 , A01N63/00 , A01N65/00 , C12N15/00 , C07H19/00 , C07H21/00 , C07H21/04
CPC分类号： C12N15/63 , A61K38/1816 , A61K48/00 , A61K48/0066 , C12N15/85 , C12N2830/002 , C12N2830/008 , C12N2830/42 , C12N2830/55 , C12N2830/702 , C12N2830/85 , C12N2830/90 , C12N2840/20 , C12N2840/44
摘要： Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
摘要翻译： 公开了一种新颖的诱导型表达系统，其特征在于在不存在诱导物的情况下不可检测的生物学效应，但在诱导物存在下表现出有效的诱导性。
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公开(公告)号：US20060211114A1
公开(公告)日：2006-09-21
申请号：US11438933
申请日：2006-05-22
IPC分类号： A61K38/17 , A61K48/00 , A61K31/335 , C12N15/87
CPC分类号： C07K14/43577 , C07K14/46 , C07K14/47 , C07K14/4702 , G01N33/573 , G01N33/6872 , G01N2500/00
摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
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4.发明授权公开(公告)号：US06733971B2
公开(公告)日：2004-05-11
申请号：US09934035
申请日：2001-08-21
IPC分类号： C12Q168
CPC分类号： C07K14/43577 , C07K14/46 , C07K14/47 , C07K14/4702 , G01N33/573 , G01N33/6872 , G01N2500/00
摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。
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公开(公告)号：US07049090B2
公开(公告)日：2006-05-23
申请号：US10677982
申请日：2003-10-01
CPC分类号： C07K14/43577 , C07K14/46 , C07K14/47 , C07K14/4702 , G01N33/573 , G01N33/6872 , G01N2500/00
摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。
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公开(公告)号：US07829333B2
公开(公告)日：2010-11-09
申请号：US11438933
申请日：2006-05-22
CPC分类号： C07K14/43577 , C07K14/46 , C07K14/47 , C07K14/4702 , G01N33/573 , G01N33/6872 , G01N2500/00
摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。
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