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    Acyclovir diester derivatives
    5.
    发明授权
    Acyclovir diester derivatives 失效
    阿昔洛韦二酯衍生物

    公开(公告)号：US06214811B1

    公开(公告)日：2001-04-10

    申请号：US09514552

    申请日：2000-02-28

    申请人： Arnold Glazier ,  Milka Yanachkova ,  Ivan Yanachkov

    发明人： Arnold Glazier ,  Milka Yanachkova ,  Ivan Yanachkov

    IPC分类号： A61K31675

    CPC分类号： C07F9/65616

    摘要： Disclosed are novel prodrugs represented by the following structural formula; Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

    摘要翻译： 公开了由以下结构式表示的新型前药：Z是氧或硫; Y与羟基，阿昔洛韦或阿昔洛韦的类似物一起; A是相对于磷酸酯在邻位或对位具有一个或多个保护的羟基或被保护的胺基的取代苄基，其可在体内转化为羟基或氨基。 还公开了一种治疗个体或动物中的病毒感染的方法。 该方法包括向个体或动物施用治疗有效量的由上述结构式表示的前药。

    Methods of preparing acyclovir prodrugs
    6.
    发明授权
    Methods of preparing acyclovir prodrugs 失效
    制备阿昔洛韦前药的方法

    公开(公告)号：US06180790B2

    公开(公告)日：2001-01-30

    申请号：US09459178

    申请日：1999-12-10

    申请人： Arnold Glazier ,  Milka Yanachkova ,  Ivan Yanachkov

    发明人： Arnold Glazier ,  Milka Yanachkova ,  Ivan Yanachkov

    IPC分类号： C07F96512

    CPC分类号： C07F9/65616

    摘要： Disclosed are novel prodrugs represented by the following structural formula: Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

    摘要翻译： 公开了由以下结构式表示的新型前药：Z是氧或硫; Y与羟基，阿昔洛韦或阿昔洛韦的类似物一起; A是相对于磷酸酯在邻位或对位具有一个或多个保护的羟基或被保护的胺基的取代苄基，其可在体内转化为羟基或氨基。 还公开了一种治疗个体或动物中的病毒感染的方法。 该方法包括向个体或动物施用治疗有效量的由上述结构式表示的前药。

    Acyclovir diester derivatives
    8.
    发明授权
    Acyclovir diester derivatives 失效
    阿昔洛韦二酯衍生物

    公开(公告)号：US6031096A

    公开(公告)日：2000-02-29

    申请号：US80064

    申请日：1998-05-15

    申请人： Arnold Glazier ,  Milka Yanachkova ,  Ivan Yanachkov

    发明人： Arnold Glazier ,  Milka Yanachkova ,  Ivan Yanachkov

    IPC分类号： A61K31/685 ,  A61K31/688 ,  A61P31/12 ,  A61P31/22 ,  C07F9/6561 ,  C07D473/18

    CPC分类号： C07F9/65616

    摘要： Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

    摘要翻译： 公开了由以下结构式表示的新型前药：Z是氧或硫; Y与羟基，阿昔洛韦或阿昔洛韦的类似物一起; A是相对于磷酸酯在邻位或对位具有一个或多个保护的羟基或被保护的胺基的取代苄基，其可在体内转化为羟基或氨基。 还公开了一种治疗个体或动物中的病毒感染的方法。 该方法包括向个体或动物施用治疗有效量的由上述结构式表示的前药。