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公开(公告)号：US20050026875A1
公开(公告)日：2005-02-03
申请号：US10737361
申请日：2003-12-15
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
IPC分类号： C07D295/14 , A61K31/65 , A61P1/02 , A61P1/04 , A61P1/12 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/02 , A61P13/10 , A61P15/00 , A61P15/14 , A61P17/00 , A61P17/02 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/06 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C237/26 , C07C275/34 , C07C323/60 , C07D207/06 , C07D207/16 , C07D207/20 , C07D207/327 , C07D207/335 , C07D207/40 , C07D207/404 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/56 , C07D213/74 , C07D213/82 , C07D213/89 , C07D231/12 , C07D233/36 , C07D261/10 , C07D261/14 , C07D261/18 , C07D263/22 , C07D277/14 , C07D277/20 , C07D277/42 , C07D277/56 , C07D295/18 , C07D295/20 , C07D307/54 , C07D317/66 , C07D211/06 , C07D265/30
CPC分类号： C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要： Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译： 讨论了氨基甲基取代的四环素化合物，药物组合物及其使用方法。
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公开(公告)号：US20080015169A1
公开(公告)日：2008-01-17
申请号：US11810336
申请日：2007-06-05
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
IPC分类号： A61K31/65 , A61K31/40 , A61K31/426 , A61P25/00 , A61P29/00 , A61P35/00 , C07D237/26 , C07D295/00 , C07D277/02 , C07D227/00 , A61P31/04 , A61P27/02 , A61P11/00 , A61K31/435
CPC分类号： C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要： Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
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公开(公告)号：US07326696B2
公开(公告)日：2008-02-05
申请号：US10737361
申请日：2003-12-15
申请人： Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人： Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
CPC分类号： C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要： Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译： 讨论了氨基甲基取代的四环素化合物，药物组合物及其使用方法。
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公开(公告)号：US20050038002A1
公开(公告)日：2005-02-17
申请号：US10740961
申请日：2003-12-18
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
IPC分类号： C07D295/20 , A61K31/65 , A61P31/04 , A61P43/00 , C07C237/26 , C07C239/18 , C07C245/20 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/06 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/52 , C07D307/54 , C07D307/68 , C07D317/54 , C07D317/60 , C07D401/04 , C07F7/10
CPC分类号： C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20050143352A1
公开(公告)日：2005-06-30
申请号：US10877928
申请日：2004-06-25
申请人： Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
发明人： Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
IPC分类号： C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , A61K31/65 , C07D221/18
CPC分类号： C07C237/48 , A61K31/65 , C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2603/46 , Y02A50/411 , Y02A50/473
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗许多四环素化合物反应状态，例如细菌感染和肿瘤，以及四环素化合物的其它已知应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20110086822A1
公开(公告)日：2011-04-14
申请号：US12901196
申请日：2010-10-08
申请人： Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Y. Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Reddy Nagavelli , Paul Sheahan , Atul K. Verma , Peter Viski , Tadeusz Warchol
发明人： Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Y. Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Reddy Nagavelli , Paul Sheahan , Atul K. Verma , Peter Viski , Tadeusz Warchol
IPC分类号： A61K31/65 , C07C237/26 , C07D307/02 , C07D493/00 , C07D211/00 , C07D405/06 , C07D265/30 , A61P31/04
CPC分类号： C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20060166945A1
公开(公告)日：2006-07-27
申请号：US11258622
申请日：2005-10-25
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号：US08466132B2
公开(公告)日：2013-06-18
申请号：US11258622
申请日：2005-10-25
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Y. Ismail , Mark L. Nelson , Kwasi Ohemeng , Jingwen Pan
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Y. Ismail , Mark L. Nelson , Kwasi Ohemeng , Jingwen Pan
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗许多四环素化合物反应状态，例如细菌感染和肿瘤，以及四环素化合物的其它已知应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20140155357A1
公开(公告)日：2014-06-05
申请号：US13918197
申请日：2013-06-14
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Y. Ismail , Mark L. Nelson , Kwasi Ohemeng , Jingwen Pan
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Y. Ismail , Mark L. Nelson , Kwasi Ohemeng , Jingwen Pan
IPC分类号： C07D471/04 , C07C237/26 , C07D277/30 , C07D207/337 , C07D213/73 , C07D231/12 , C07D211/70 , C07D307/54
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗许多四环素化合物反应状态，例如细菌感染和肿瘤，以及四环素化合物的其他已知应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20070093455A1
公开(公告)日：2007-04-26
申请号：US11490867
申请日：2006-07-21
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07D295/155 , C07C237/26 , C07C309/65 , C07D207/06 , C07D211/14 , C07D239/26 , C07D263/58 , C07D265/12 , C07D307/77 , C07D307/81
摘要： 10-Substituted tetracycline compounds are described.
摘要翻译： 描述了10-取代的四环素化合物。
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