摘要:
An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
摘要:
An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
摘要:
The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
摘要:
A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.
摘要:
A method for detecting one or more target bacteria in a raw sample where: 1) bacteriophage(s) specific to each target bacterium are added to the raw sample, 2) the test sample is incubated, and 3) the test sample is tested for the presence of each phage in sufficient numbers to indicate the presence of the associated target bacteria in the raw sample. In one embodiment, each phage is initially added to the raw sample in concentrations below the detection limit of the final phage detection process. In another embodiment, the parent phages are tagged in such a way that they can be separated from the progeny phage prior to the detection process. Preferred phage detection processes are immunoassay methods utilizing antibodies that bind specifically to each phage. Antibodies can be used that bind to the protein capsid of the phage. Alternatively, the phage can by dissociated after the incubation process and the sample tested for the presence of individual capsid proteins or phage nucleic acids. The invention can be used to test target bacteria for antibiotic resistance.
摘要:
A method and apparatus for improving the successful transmission of facsimile data over a wireless communication channel is provided comprising a facsimile machine, a wireless transceiver and a connector interfacing therebetween. The facsimile machine detects an interface with the wireless transceiver and notifies the facsimile machine of a wireless communication channel through which facsimile data will traverse. The facsimile machine, in conjunction with the wireless transceiver, establishes a wireless communication channel according to an initial data transfer rate corresponding with the capability of the wireless transceiver or known communication channel conditions. The facsimile machine then exchanges facsimile data over the wireless communication channel and a receiving facsimile machine evaluates the facsimile data to detect errors injected through the wireless communication channel. When such errors are detected, the facsimile machine may institute retransmission of the previous facsimile data relying upon an anticipated improved condition of the wireless communication channel. When the conditions of this wireless communication channel have not improved, the facsimile machine renegotiates a data transfer rate more conducive with the present capability of the wireless communication channel. A facsimile machine further determines when the wireless transceiver is removed and reverts back to traditional wired communication channel data rates.
摘要:
The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
摘要:
The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.
摘要:
A compact material marking system and method uses a laser to mark materials such as fabrics in environments such as stores with safety and ease of use being addressed. The system includes a housing containing the laser, gas filters, and other equipment such as fans. Material to be marked is placed into a cassette box having an opening exposing the material. The cassette is engaged with an enclosure that is coupled to the housing to allow the laser beam from the laser to enter the enclosure and to strike the material found in the engaged cassette. Fumes caused by interaction of the laser beam with the material are contained by the enclosure and drawn away to be filtered. Sensors are employed so that the laser can be activated only when the cassette is fully engaged with the enclosure.
摘要:
Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.