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    Two component dispenser system
    1.
    发明授权
    Two component dispenser system 失效
    双组分分配器系统

    公开(公告)号：US06527749B1

    公开(公告)日：2003-03-04

    申请号：US09595961

    申请日：2000-06-19

    申请人： Mark S. Roby ,  Ernie Aranyi ,  Richard Yagami ,  H. Jonathan Tovey

    发明人： Mark S. Roby ,  Ernie Aranyi ,  Richard Yagami ,  H. Jonathan Tovey

    IPC分类号： A61M500

    CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61B2017/2837

    摘要： An applicator is provided for dispensing a first and a second protein solution to form a biological adhesive where the solutions can be deflected by a deflection assembly during dispensing for the adhesive to cover a broad or limited area. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing a first component, and a second reservoir containing a second component. The first and second components are preferably fibrinogen and thrombin which intermix with water to form the first and second protein solutions, respectively. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. The solutions intermix on an application site to form a fibrin sealant. In an alternate embodiment, the applicator includes two valves. A first valve opens and closes the proximal ends of two conduit assemblies for introducing water or other substance to the reservoirs. A second valve opens and closes the distal ends of the two conduit assemblies to permit and prevent the dispensing of the protein solutions.

    摘要翻译： 提供施用器用于分配第一和第二蛋白质溶液以形成生物粘合剂，其中在分配粘合剂以覆盖宽的或有限的区域期间，溶液可被偏转组件偏转。 施加器包括壳体，该壳体具有壳体头部，用于在其中封装包含第一部件的第一储存器和包含第二部件的第二储存器。 第一和第二组分优选分别与水混合以形成第一和第二蛋白质溶液的纤维蛋白原和凝血酶。 壳体还包括限定纵向轴线的细长主体部分，用于在其中封闭具有分别与第一和第二储存器连通的第一和第二导管的导管组件。 溶液在应用场所混合形成纤维蛋白密封胶。 在替代实施例中，施加器包括两个阀。 第一阀打开和关闭两个导管组件的近端，用于将水或其他物质引入储存器。 第二阀打开和关闭两个导管组件的远端以允许和防止蛋白质溶液的分配。

    Fibrin mixture and dispenser assembly
    2.
    发明授权
    Fibrin mixture and dispenser assembly 失效
    纤维蛋白混合物和分配器组件

    公开(公告)号：US06764467B1

    公开(公告)日：2004-07-20

    申请号：US09595962

    申请日：2000-06-19

    申请人： Mark S. Roby ,  Ernie Aranyi ,  Richard Yagami ,  H. Jonathan Tovey

    发明人： Mark S. Roby ,  Ernie Aranyi ,  Richard Yagami ,  H. Jonathan Tovey

    IPC分类号： A61M500

    CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61J1/16 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2058 ,  A61J1/2089

    摘要： A fibrin mixture and dispenser assembly is provided for mixing a first protein component with sterile water to form a first protein solution and for dispensing the first protein solution. The first protein solution forms a biological adhesive when intermixed with a second protein solution. The second protein solution is preferably mixed and dispensed by a similar fibrin mixture and dispenser assembly. The two fibrin mixture and dispenser assemblies can be housed within a single housing. The assembly includes a piercer and a first tubular extension having grooves for providing fluid communication between a reservoir and a mixing chamber or a vial. The reservoir is also in fluid communication with a dispensing needle through a second tubular extension. The reservoir is configured to contain water which is introduced to the mixing chamber. The mixing chamber is configured to contain the first protein component. The water mixes with the first protein component within the mixing chamber to form the first protein solution. The solution is transferred to the reservoir and is dispensed via the dispensing needle. The first and second components are preferably fibrinogen and thrombin which intermix either prior to or on the application site to form a fibrin sealant.

    摘要翻译： 提供纤维蛋白混合物和分配器组件用于将第一蛋白质组分与无菌水混合以形成第一蛋白质溶液并用于分配第一蛋白质溶液。 当与第二蛋白质溶液混合时，第一种蛋白质溶液形成生物粘合剂。 第二蛋白质溶液优选地通过类似的纤维蛋白混合物和分配器组件混合和分配。 两个纤维蛋白混合物和分配器组件可以容纳在单个壳体内。 组件包括穿孔器和第一管状延伸部，其具有用于在贮存器和混合室或小瓶之间提供流体连通的凹槽。 储存器还通过第二管状延伸部与分配针流体连通。 储存器构造成包含被引入混合室的水。 混合室配置成容纳第一蛋白质组分。 水与混合室内的第一蛋白质组分混合以形成第一蛋白质溶液。 将溶液转移到储存器中并通过分配针分配。 第一和第二组分优选纤维蛋白原和凝血酶，其在施用部位之前或之上混合以形成纤维蛋白密封剂。

    Bioabsorbable Adhesive Compounds And Compositions
    3.
    发明申请
    Bioabsorbable Adhesive Compounds And Compositions 有权
    生物可吸收粘合剂和组合物

    公开(公告)号：US20100021414A1

    公开(公告)日：2010-01-28

    申请号：US12563653

    申请日：2009-09-21

    申请人： Mark S. Roby

    发明人： Mark S. Roby

    IPC分类号： A61L24/04

    CPC分类号： C08G18/10 ,  A61K31/785 ,  A61L24/0042 ,  A61L24/043 ,  A61L24/046 ,  C08G18/3225 ,  C08G18/48 ,  C08G18/5024 ,  C08G18/73 ,  C08G18/735 ,  C08G18/771 ,  C08G2190/00 ,  C08G2230/00 ,  C09J175/02 ,  C09J175/04 ,  C09J175/08 ,  C08L71/02 ,  C08G18/50 ,  C08G18/3821

    摘要： Bioabsorbable compounds which include a polyalkylene oxide backbone with two or more isocyanate substituents are useful as one component adhesives. Absorbable compositions useful as a two component adhesive contain a) a polyethylene oxide having two or more amine substituents with b) a bioabsorbable diisocyanate compound, or alternatively contain a) a polyethylene oxide having two or more isocyanate substituents with b) a bioabsorbable diamine compound, or, alternatively contain a) a bioabsorbable diisocyanate compound and b) a bioabsorbable diamine compound.

    摘要翻译： 包含具有两个或更多个异氰酸酯取代基的聚环氧烷主链的生物可吸收化合物可用作单组分粘合剂。 可用作双组分粘合剂的可吸收组合物包含a）具有两个或多个胺取代基的聚环氧乙烷，b）生物可吸收二异氰酸酯化合物，或者备选地包含a）具有两个或多个异氰酸酯取代基的聚环氧乙烷，b）生物可吸收二胺化合物， 或者可选地含有a）生物可吸收二异氰酸酯化合物和b）生物可吸收二胺化合物。

    Synthetic copolymer surgical articles and method of manufacturing the same
    8.
    发明授权
    Synthetic copolymer surgical articles and method of manufacturing the same 失效
    合成共聚物外科用品及其制造方法

    公开(公告)号：US4429080A

    公开(公告)日：1984-01-31

    申请号：US394347

    申请日：1982-07-01

    申请人： Donald J. Casey ,  Mark S. Roby

    发明人： Donald J. Casey ,  Mark S. Roby

    IPC分类号： A61L17/00 ,  A61K9/20 ,  A61L17/12 ,  C08G63/08 ,  C08G63/64 ,  C08G63/76 ,  C08L67/00

    CPC分类号： C08G63/64 ,  A61K9/204 ,  A61L17/12 ,  C08G63/08

    摘要： A triblock copolymer having a proportion of units having the formula: ##STR1## as the end blocks, and the formula (I) randomly combined with a proportion of units having the formula: ##STR2## as the middle block finds particular advantageous use in manufacturing absorbable monofilament sutures and other surgical articles. A surgical article is manufactured from a synthetic absorbable copolymer formed by copolymerizing glycolide with 1,3-dioxan-2-one (trimethylene carbonate) wherein a combination of the monomers is substantially completely polymerized before the addition of the other monomer in the presence of a difunctional initiator at or below about 180.degree. C.; glycolide is added and the temperature increased up to about the melting point of poly glycolide to form a triblock copolymer with a proportion of units having the formula: ##STR3## as the end blocks, and the formula (I) randomly combined with a proportion of units having the formula: ##STR4## as the middle block.

    摘要翻译： 具有下列结构式的单元比例的三嵌段共聚物作为末端嵌段，式（I）与下式的单元比例随机组合：作为中间嵌段 在制造可吸收的单丝缝合线和其它外科用品时发现特别有利的用途。 手术用品由由乙交酯与1,3-二恶烷-2-酮（三亚甲基碳酸酯）共聚形成的合成可吸收共聚物制成，其中单体的组合在加入其它单体之前基本上完全聚合， 双官能引发剂在约180℃或低于约180℃。 加入乙交酯并将温度升高至约聚乙交酯的熔点，形成具有下式的单元比例的三嵌段共聚物作为末端嵌段，式（I）随机与 一部分具有以下公式的单位：（II）作为中间块。

    Composite materials and surgical articles made therefrom
    10.
    发明授权
    Composite materials and surgical articles made therefrom 失效
    由其制成的复合材料和外科用品

    公开(公告)号：US06315788B1

    公开(公告)日：2001-11-13

    申请号：US09032694

    申请日：1998-02-28

    申请人： Mark S. Roby

    发明人： Mark S. Roby

    IPC分类号： A61B1700

    CPC分类号： A61L15/26 ,  A61L17/04 ,  A61L17/12 ,  A61L17/145 ,  A61L27/48 ,  A61L31/129 ,  C08L67/04

    摘要： Composite materials have a core portion formed from a polyalkylene oxide initiated block copolymer having one of the blocks made from hard phase forming monomers and another of the blocks made from random copolymers of soft phase forming monomers and at least one shell portion formed from a block copolymer having one of the blocks made from hard phase forming monomers and another of the blocks made from random copolymers of soft phase forming monomers joined to the core portion. Hard phase forming monomers include glycolide and lactide while soft phase forming monomers include 1,4 dioxane-2-one, 1,3 dioxane-2-one and caprolactone. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The composite materials may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.

    摘要翻译： 复合材料具有由聚环氧烷引发的嵌段共聚物形成的核心部分，其具有由硬相形成单体制成的嵌段之一和由软相形成单体的无规共聚物制成的嵌段和由嵌段共聚物形成的至少一个壳部分 具有由硬相形成单体制成的块中的一个和由与形成芯部的结合的软相形成单体的无规共聚物制成的另一嵌段。 硬相形成单体包括乙交酯和丙交酯，而软相形成单体包括1,4-二恶烷-2-酮，1,3-二恶烷-2-酮和己内酯。 在优选实施例中，芯部与外壳部分共挤出以形成复合丝或片。 复合材料可以用作缝线或形成用于植入生物体内的医疗装置或外科用品。