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    Clustering of recorded patient neurological activity to determine length of a neurological event
    1.
    发明授权
    Clustering of recorded patient neurological activity to determine length of a neurological event 有权
    记录患者神经活动的聚类，以确定神经系统事件的长度

    公开(公告)号：US07933646B2

    公开(公告)日：2011-04-26

    申请号：US11837987

    申请日：2007-08-13

    申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC分类号： A61B5/04

    CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

    摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

    Clustering of recorded patient neurological activity to determine length of a neurological event
    2.
    发明授权
    Clustering of recorded patient neurological activity to determine length of a neurological event 有权
    记录患者神经活动的聚类，以确定神经系统事件的长度

    公开(公告)号：US07280867B2

    公开(公告)日：2007-10-09

    申请号：US10687571

    申请日：2003-10-15

    申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04012 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/7217 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  Y10S128/92

    摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

    Therapy target selection for psychiatric disorder therapy
    3.
    发明授权
    Therapy target selection for psychiatric disorder therapy 有权

    公开(公告)号：US10688303B2

    公开(公告)日：2020-06-23

    申请号：US12425758

    申请日：2009-04-17

    申请人： Mark T. Rise ,  Jonathon E. Giftakis

    发明人： Mark T. Rise ,  Jonathon E. Giftakis

    IPC分类号： A61N1/36

    摘要： Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.

    Clustering of recorded patient neurological activity to determine length of a neurological event
    5.
    发明授权
    Clustering of recorded patient neurological activity to determine length of a neurological event 有权
    记录患者神经活动的聚类，以确定神经系统事件的长度

    公开(公告)号：US08738136B2

    公开(公告)日：2014-05-27

    申请号：US11837994

    申请日：2007-08-13

    申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC分类号： A61N1/36

    CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

    摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件如癫痫发作相关联的检测簇，以及与治疗疗法相关联的更新治疗参数。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

    Screening techniques for management of a nervous system disorder
    6.
    发明授权
    Screening techniques for management of a nervous system disorder 有权
    用于管理神经系统疾病的筛查技术

    公开(公告)号：US08579786B2

    公开(公告)日：2013-11-12

    申请号：US10687344

    申请日：2003-10-15

    申请人： Ivan Osorio ,  Mark G. Frei ,  Naresh C. Bhavaraju ,  Thomas E. Peters ,  Nina M. Graves ,  Scott F. Schaffner ,  Jonathon E. Giftakis ,  Mark T. Rise ,  Jonathan C. Werder

    发明人： Ivan Osorio ,  Mark G. Frei ,  Naresh C. Bhavaraju ,  Thomas E. Peters ,  Nina M. Graves ,  Scott F. Schaffner ,  Jonathon E. Giftakis ,  Mark T. Rise ,  Jonathan C. Werder

    IPC分类号： A61N2/00

    CPC分类号： A61N1/08 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/7275 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/37217

    摘要： Apparatus and method support a neurological event screening for a medical device. The medical device assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.

    摘要翻译： 装置和方法支持用于医疗装置的神经事件筛查。 医疗装置帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。 医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。 用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。 向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。 用户可以修改配置和治疗参数，以达到功效和验收。 根据患者的接受程度，治疗以开环模式或闭环模式应用。 医疗设备根据标准确定治疗是否成功。

    AROUSAL STATE MODULATION WITH ELECTRICAL STIMULATION
    7.
    发明申请
    AROUSAL STATE MODULATION WITH ELECTRICAL STIMULATION 有权
    具有电刺激的震颤状态调制

    公开(公告)号：US20120116475A1

    公开(公告)日：2012-05-10

    申请号：US13288797

    申请日：2011-11-03

    申请人： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

    发明人： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

    IPC分类号： A61N1/36

    CPC分类号： A61N1/00 ,  A61N1/0534 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/37282

    摘要： In some examples, an arousal network of a brain of a patient can be activated to modify the arousal state of the patient, which may be useful in treating a cognitive disorder of the patient. In some examples, a bioelectrical brain signal indicative of electrical activity in a first portion of the brain is monitored to determine whether the patient is in a first arousal state, and, in response to determining the patient is in the first arousal state, electrical stimulation is delivered to a second portion of the brain to activate an arousal neural network in the first portion of the brain to induce a second arousal state to treat the cognitive disorder, where the second arousal state is different than the first arousal state.

    摘要翻译： 在一些实例中，患者的脑的唤醒网络可以被激活以修改患者的觉醒状态，其可用于治疗患者的认知障碍。 在一些实例中，监测指示脑的第一部分中的电活动的生物电脑信号，以确定患者是否处于第一觉醒状态，并且响应于确定患者处于第一次唤醒状态，电刺激 被输送到大脑的第二部分以激活脑的第一部分中的觉醒神经网络以诱导第二觉醒状态来治疗认知障碍，其中第二觉醒状态不同于第一觉醒状态。

    THERAPY TARGET SELECTION FOR PSYCHIATRIC DISORDER THERAPY
    9.
    发明申请
    THERAPY TARGET SELECTION FOR PSYCHIATRIC DISORDER THERAPY 审中-公开
    治疗精神疾病治疗方案的治疗目标选择

    公开(公告)号：US20090264954A1

    公开(公告)日：2009-10-22

    申请号：US12425758

    申请日：2009-04-17

    申请人： Mark T. Rise ,  Jonathon E. Giftakis

    发明人： Mark T. Rise ,  Jonathon E. Giftakis

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36082

    摘要： Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.

    摘要翻译： 可以基于患者症状或患者情绪状态来选择用于治疗递送给患者的靶组织位点。 治疗递送可用于治疗患者的精神疾病。 可以基于诸如患者症状或情绪状态的严重性或患者症状或情绪状态的类型的因素来加权所选择的治疗部位。 在一些情况下，可以基于加权因子来控制对患者的治疗递送。 例如，加权因子可以控制治疗递送的强度或治疗递送的频率。 在一些示例中，加权因子可以基于患者的改变的症状或情绪障碍而动态地改变。

    ANXIETY DISORDER MONITORING
    10.
    发明申请
    ANXIETY DISORDER MONITORING 审中-公开
    安静的异常监视

    公开(公告)号：US20100280336A1

    公开(公告)日：2010-11-04

    申请号：US12751537

    申请日：2010-03-31

    申请人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski

    发明人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0476 ,  A61B5/1118 ,  A61B5/165 ,  A61B5/4803 ,  A61B5/6846 ,  A61B5/7267

    摘要： An anxiety episode may be identified as being an anxiety event that is attributable to an anxiety disorder of a patient based on the patient activity associated with the anxiety episode. The patient activity may include, for example, patient motion, patient posture or voice activity. Detection of the activity component during an anxiety episode can help distinguish between a general anxiety state and an anxiety event that differs from the general anxiety state. Examples of anxiety events include, for example, an occurrence of a compulsion or a panic attack. The detected anxiety events can be used to evaluate an anxiety disorder of a patient, evaluate therapy programs implemented by a medical device to treat the anxiety disorder, or control therapy delivery. In some examples, a mood state transition is detected based on patient activity information and therapy delivery is controlled based on the detection of the mood state transition.

    摘要翻译： 基于与焦虑发作相关的患者活动，可能将焦虑事件确定为可归因于患者的焦虑症的焦虑事件。 患者活动可以包括例如患者运动，患者姿势或语音活动。 在焦虑症状期间检测活动成分可以帮助区分一般焦虑状态和与一般焦虑状态不同的焦虑事件。 焦虑事件的例子包括例如强迫或惊恐发作的发生。 检测到的焦虑事件可用于评估患者的焦虑症，评估由医疗装置实施的治疗程序以治疗焦虑症或控制治疗递送。 在一些示例中，基于患者活动信息检测情绪状态转换，并且基于心情状态转换的检测来控制治疗递送。