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1.发明授权Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction 失效合成卤素碱基修饰寡核苷酸的方法，随后用金属催化反应进行标记公开(公告)号：US06288221B1
公开(公告)日：2001-09-11
申请号：US09377612
申请日：1999-08-19
IPC分类号： C07H2100
摘要： The present invention provides metal-containing purines, pyrimidines, nucleosides, nucleotides and oligonucleotides; including phosphoramidite and photolabile derivatives thereof, including methods of making and method of using same. The present invention provides a method for detection of nucleic acid sequences via electrochemical or photochemical means.
摘要翻译： 本发明提供含金属嘌呤，嘧啶，核苷，核苷酸和寡核苷酸; 包括亚磷酰胺及其不透光衍生物，包括制备方法及其使用方法。 本发明提供了通过电化学或光化学方法检测核酸序列的方法。
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公开(公告)号：US08334324B2
公开(公告)日：2012-12-18
申请号：US12690607
申请日：2010-01-20
IPC分类号： A61K47/06
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
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3.发明授权Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof 失效由合成聚合物制备的用于医学成像的聚合物壳及其使用方法
公开(公告)号：US5512268A
公开(公告)日：1996-04-30
申请号：US486268
申请日：1995-06-06
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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公开(公告)号：US08338492B2
公开(公告)日：2012-12-25
申请号：US12818693
申请日：2010-06-18
IPC分类号： A61K47/06
CPC分类号： A61K47/32 , A61K31/337 , A61K31/519 , A61K38/14 , A61K38/50 , C07D319/06 , C08F124/00 , Y10T428/2982
摘要： Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
摘要翻译： 本文描述了可用于制备聚合物基膜，颗粒，凝胶和相关组合物的化合物和方法，以及用于递送试剂的方法和其它用途。
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5.发明授权
公开(公告)号：US5665383A
公开(公告)日：1997-09-09
申请号：US488804
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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公开(公告)号：US5508021A
公开(公告)日：1996-04-16
申请号：US326116
申请日：1994-10-19
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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7.发明授权Composition useful for in vivo delivery of biologics and methods employing same 失效可用于体内递送生物制剂的组合物和使用其的方法
公开(公告)号：US5498421A
公开(公告)日：1996-03-12
申请号：US200235
申请日：1994-02-22
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
IPC分类号： A23L33/00 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K38/00 , A61K9/127
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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公开(公告)号：US09393344B2
公开(公告)日：2016-07-19
申请号：US11653433
申请日：2007-01-11
IPC分类号： A61K31/74 , A61L24/04 , A61K31/785 , A61K31/787 , A61L27/18 , A61B17/00
CPC分类号： A61L26/0019 , A61B2017/0065 , A61B2017/00951 , A61K31/785 , A61K31/787 , A61K51/1279 , A61L24/0031 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L26/0052 , A61L26/008 , A61L26/0085 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/56 , C08L79/02
摘要： One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.
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9.发明申请DOPING AGENTS AND POLYMERIC COMPOSITIONS THEREOF FOR CONTROLLED DRUG DELIVERY 审中-公开用于控制药物递送的掺合剂及其聚合物组合物公开(公告)号：US20150037375A1
公开(公告)日：2015-02-05
申请号：US14233570
申请日：2012-07-19
申请人： Mark W. Grinstaff , Jesse Wolinsky , Stefan Yohe , Jonah Andrew Kaplan , Eric John Falde , Joseph Steven Hersey
发明人： Mark W. Grinstaff , Jesse Wolinsky , Stefan Yohe , Jonah Andrew Kaplan , Eric John Falde , Joseph Steven Hersey
CPC分类号： A61L31/148 , A61K9/0024 , A61K9/70 , A61K31/337 , A61K31/4745 , A61K41/0028 , A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/602 , A61L2300/802 , C08L67/04
摘要： Provided herein are 3-dimensional drug-eluting materials comprising biodegradable polymer(s), one or more bioactive agents and entrapped air. Various embodiments of the methods and compositions described herein are based, in part, on the discovery of hydrophobic doping agents that can be used in the manufacture of polymeric drug delivery compositions that permit the encapsulation of air, thereby permitting tunable drug release via controlled air removal. Such compositions are particularly useful for delivering therapeutically effective doses of one or more bioactive agents to a subject over an extended period of time (e.g., days, weeks, or months).
摘要翻译： 本文提供了包含可生物降解的聚合物，一种或多种生物活性剂和捕获的空气的三维药物洗脱物质。 本文描述的方法和组合物的各种实施方案部分地基于可用于制造可以包封空气的聚合物药物递送组合物的疏水性掺杂剂的发现，从而通过可控的空气去除来允许可调节的药物释放 。 这样的组合物特别可用于在长时间（例如，几天，几周或几个月）内向受试者递送治疗有效剂量的一种或多种生物活性剂。
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公开(公告)号：US08378064B2
公开(公告)日：2013-02-19
申请号：US12301410
申请日：2007-05-18
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： A61K38/00 , A61K47/00 , A61K31/715 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H1/00 , A01N25/00 , A01N43/04
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译： 本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。 本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。 还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。
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